Differences in accumulation and virulence determine the outcome of competition during Tobacco etch virus coinfection.
Understanding the evolution of virulence for RNA viruses is essential for developing appropriate control strategies. Although it has been usually assumed that virulence is a consequence of within-host replication of the parasite, viral strains may be highly virulent without experiencing large accumu...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-03-01
|
| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21423618/?tool=EBI |
| _version_ | 1819036796595470336 |
|---|---|
| author | Guillaume Lafforgue Josep Sardanyés Santiago F Elena |
| author_facet | Guillaume Lafforgue Josep Sardanyés Santiago F Elena |
| author_sort | Guillaume Lafforgue |
| collection | DOAJ |
| description | Understanding the evolution of virulence for RNA viruses is essential for developing appropriate control strategies. Although it has been usually assumed that virulence is a consequence of within-host replication of the parasite, viral strains may be highly virulent without experiencing large accumulation as a consequence of immunopathological host responses. Using two strains of Tobacco etch potyvirus (TEV) that show a negative relationship between virulence and accumulation rate, we first explored the evolution of virulence and fitness traits during simple and mixed infections. Short-term evolution experiments initiated with each strain independently confirmed the genetic and evolutionary stability of virulence and viral load, although infectivity significantly increased for both strains. Second, competition experiments between hypo- and hypervirulent TEV strains have shown that the outcome of competition is driven by differences in replication rate. A simple mathematical model has been developed to analyze the dynamics of these two strains during coinfection. The model qualitatively reproduced the experimental results using biologically meaningful parameters. Further analyses of the model also revealed a wide parametric region in which a low-fitness but hypovirulent virus can still outcompete a high-fitness but hypervirulent one. These results provide additional support to the observation that virulence and within-host replication may not necessarily be strongly tied in plant RNA viruses. |
| first_indexed | 2024-12-21T08:11:13Z |
| format | Article |
| id | doaj.art-57bb85533e674650a181f57d9779d5ef |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T08:11:13Z |
| publishDate | 2011-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-57bb85533e674650a181f57d9779d5ef2022-12-21T19:10:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-03-0163e1791710.1371/journal.pone.0017917Differences in accumulation and virulence determine the outcome of competition during Tobacco etch virus coinfection.Guillaume LafforgueJosep SardanyésSantiago F ElenaUnderstanding the evolution of virulence for RNA viruses is essential for developing appropriate control strategies. Although it has been usually assumed that virulence is a consequence of within-host replication of the parasite, viral strains may be highly virulent without experiencing large accumulation as a consequence of immunopathological host responses. Using two strains of Tobacco etch potyvirus (TEV) that show a negative relationship between virulence and accumulation rate, we first explored the evolution of virulence and fitness traits during simple and mixed infections. Short-term evolution experiments initiated with each strain independently confirmed the genetic and evolutionary stability of virulence and viral load, although infectivity significantly increased for both strains. Second, competition experiments between hypo- and hypervirulent TEV strains have shown that the outcome of competition is driven by differences in replication rate. A simple mathematical model has been developed to analyze the dynamics of these two strains during coinfection. The model qualitatively reproduced the experimental results using biologically meaningful parameters. Further analyses of the model also revealed a wide parametric region in which a low-fitness but hypovirulent virus can still outcompete a high-fitness but hypervirulent one. These results provide additional support to the observation that virulence and within-host replication may not necessarily be strongly tied in plant RNA viruses.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21423618/?tool=EBI |
| spellingShingle | Guillaume Lafforgue Josep Sardanyés Santiago F Elena Differences in accumulation and virulence determine the outcome of competition during Tobacco etch virus coinfection. PLoS ONE |
| title | Differences in accumulation and virulence determine the outcome of competition during Tobacco etch virus coinfection. |
| title_full | Differences in accumulation and virulence determine the outcome of competition during Tobacco etch virus coinfection. |
| title_fullStr | Differences in accumulation and virulence determine the outcome of competition during Tobacco etch virus coinfection. |
| title_full_unstemmed | Differences in accumulation and virulence determine the outcome of competition during Tobacco etch virus coinfection. |
| title_short | Differences in accumulation and virulence determine the outcome of competition during Tobacco etch virus coinfection. |
| title_sort | differences in accumulation and virulence determine the outcome of competition during tobacco etch virus coinfection |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21423618/?tool=EBI |
| work_keys_str_mv | AT guillaumelafforgue differencesinaccumulationandvirulencedeterminetheoutcomeofcompetitionduringtobaccoetchviruscoinfection AT josepsardanyes differencesinaccumulationandvirulencedeterminetheoutcomeofcompetitionduringtobaccoetchviruscoinfection AT santiagofelena differencesinaccumulationandvirulencedeterminetheoutcomeofcompetitionduringtobaccoetchviruscoinfection |