Hydroxypropyl Cellulose/Pluronic-Based Composite Hydrogels as Biodegradable Mucoadhesive Scaffolds for Tissue Engineering
Recently, the development of new materials with the desired characteristics for functional tissue engineering, ensuring tissue architecture and supporting cellular growth, has gained significant attention. Hydrogels, which possess similar properties to natural cellular matrixes, being able to repair...
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MDPI AG
2022-08-01
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| Online Access: | https://www.mdpi.com/2310-2861/8/8/519 |
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| author | Daniela Filip Doina Macocinschi Mirela-Fernanda Zaltariov Bianca-Iulia Ciubotaru Alexandra Bargan Cristian-Dragos Varganici Ana-Lavinia Vasiliu Dragos Peptanariu Mihaela Balan-Porcarasu Mihaela-Madalina Timofte-Zorila |
| author_facet | Daniela Filip Doina Macocinschi Mirela-Fernanda Zaltariov Bianca-Iulia Ciubotaru Alexandra Bargan Cristian-Dragos Varganici Ana-Lavinia Vasiliu Dragos Peptanariu Mihaela Balan-Porcarasu Mihaela-Madalina Timofte-Zorila |
| author_sort | Daniela Filip |
| collection | DOAJ |
| description | Recently, the development of new materials with the desired characteristics for functional tissue engineering, ensuring tissue architecture and supporting cellular growth, has gained significant attention. Hydrogels, which possess similar properties to natural cellular matrixes, being able to repair or replace biological tissues and support the healing process through cellular proliferation and viability, are a challenge when designing tissue scaffolds. This paper provides new insights into hydrogel-based polymeric blends (hydroxypropyl cellulose/Pluronic F68), aiming to evaluate the contributions of both components in the development of new tissue scaffolds. In order to study the interactions within the hydrogel blends, FTIR and <sup>1</sup>HNMR spectroscopies were used. The porosity and the behavior in moisture medium were highlighted by SEM and DVS analyses. The biodegradability of the hydrogel blends was studied in a simulated biological medium. The hydrogel composition was determinant for the scaffold behavior: the HPC component was found to have a great influence on the BET and GAB areas, on the monolayer values estimated from sorption–desorption isotherms and on mucoadhesivity on small intestine mucosa, while the Pluronic F68 component improved the thermal stability. All blends were also found to have good mechanical strength and increased biocompatibility on the NHDF cell line. Based on their particular compositions and increased mucoadhesivity on small intestine mucosa, these polymeric blends could be effective in the repair or recovery of damaged cell membranes (due to the contribution of Pluronic F68) or in control drug-delivery intestinal formulations. |
| first_indexed | 2024-03-09T04:24:49Z |
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| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T04:24:49Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-57bc9cf73e5e40eb8fc9f6eda1bbfd7c2023-12-03T13:42:22ZengMDPI AGGels2310-28612022-08-018851910.3390/gels8080519Hydroxypropyl Cellulose/Pluronic-Based Composite Hydrogels as Biodegradable Mucoadhesive Scaffolds for Tissue EngineeringDaniela Filip0Doina Macocinschi1Mirela-Fernanda Zaltariov2Bianca-Iulia Ciubotaru3Alexandra Bargan4Cristian-Dragos Varganici5Ana-Lavinia Vasiliu6Dragos Peptanariu7Mihaela Balan-Porcarasu8Mihaela-Madalina Timofte-Zorila9Laboratory of Physical Chemistry of Polymers, “Petru Poni” Institute of Macromolecular Chemistry, Aleea Gr. Ghica Voda 41 A, 700487 Iasi, RomaniaLaboratory of Physical Chemistry of Polymers, “Petru Poni” Institute of Macromolecular Chemistry, Aleea Gr. Ghica Voda 41 A, 700487 Iasi, RomaniaDepartment of Inorganic Polymers, “Petru Poni” Institute of Macromolecular Chemistry, Aleea Gr. Ghica Voda 41 A, 700487 Iasi, RomaniaDepartment of Inorganic Polymers, “Petru Poni” Institute of Macromolecular Chemistry, Aleea Gr. Ghica Voda 41 A, 700487 Iasi, RomaniaDepartment of Inorganic Polymers, “Petru Poni” Institute of Macromolecular Chemistry, Aleea Gr. Ghica Voda 41 A, 700487 Iasi, RomaniaCentre of Advanced Research in Bionanoconjugates and Biopolymers, “Petru Poni” Institute of Macromolecular Chemistry, Aleea Gr. Ghica Voda 41 A, 700487 Iasi, RomaniaLaboratory of Functional Polymers, “Petru Poni” Institute of Macromolecular Chemistry, Aleea Gr. Ghica Voda 41 A, 700487 Iasi, RomaniaCentre of Advanced Research in Bionanoconjugates and Biopolymers, “Petru Poni” Institute of Macromolecular Chemistry, Aleea Gr. Ghica Voda 41 A, 700487 Iasi, RomaniaLaboratory of Polycondensation and Thermostable Polymers, “Petru Poni” Institute of Macromolecular Chemistry, Aleea Gr. Ghica Voda 41 A, 700487 Iasi, RomaniaSaint Spiridon County Hospital, Bulevardul Independentei 1, “Gr. T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaRecently, the development of new materials with the desired characteristics for functional tissue engineering, ensuring tissue architecture and supporting cellular growth, has gained significant attention. Hydrogels, which possess similar properties to natural cellular matrixes, being able to repair or replace biological tissues and support the healing process through cellular proliferation and viability, are a challenge when designing tissue scaffolds. This paper provides new insights into hydrogel-based polymeric blends (hydroxypropyl cellulose/Pluronic F68), aiming to evaluate the contributions of both components in the development of new tissue scaffolds. In order to study the interactions within the hydrogel blends, FTIR and <sup>1</sup>HNMR spectroscopies were used. The porosity and the behavior in moisture medium were highlighted by SEM and DVS analyses. The biodegradability of the hydrogel blends was studied in a simulated biological medium. The hydrogel composition was determinant for the scaffold behavior: the HPC component was found to have a great influence on the BET and GAB areas, on the monolayer values estimated from sorption–desorption isotherms and on mucoadhesivity on small intestine mucosa, while the Pluronic F68 component improved the thermal stability. All blends were also found to have good mechanical strength and increased biocompatibility on the NHDF cell line. Based on their particular compositions and increased mucoadhesivity on small intestine mucosa, these polymeric blends could be effective in the repair or recovery of damaged cell membranes (due to the contribution of Pluronic F68) or in control drug-delivery intestinal formulations.https://www.mdpi.com/2310-2861/8/8/519hydroxypropyl cellulosepolymeric blendsdynamic vapor sorptionbiocompatibilitymucoadhesive gelstissue engineering |
| spellingShingle | Daniela Filip Doina Macocinschi Mirela-Fernanda Zaltariov Bianca-Iulia Ciubotaru Alexandra Bargan Cristian-Dragos Varganici Ana-Lavinia Vasiliu Dragos Peptanariu Mihaela Balan-Porcarasu Mihaela-Madalina Timofte-Zorila Hydroxypropyl Cellulose/Pluronic-Based Composite Hydrogels as Biodegradable Mucoadhesive Scaffolds for Tissue Engineering Gels hydroxypropyl cellulose polymeric blends dynamic vapor sorption biocompatibility mucoadhesive gels tissue engineering |
| title | Hydroxypropyl Cellulose/Pluronic-Based Composite Hydrogels as Biodegradable Mucoadhesive Scaffolds for Tissue Engineering |
| title_full | Hydroxypropyl Cellulose/Pluronic-Based Composite Hydrogels as Biodegradable Mucoadhesive Scaffolds for Tissue Engineering |
| title_fullStr | Hydroxypropyl Cellulose/Pluronic-Based Composite Hydrogels as Biodegradable Mucoadhesive Scaffolds for Tissue Engineering |
| title_full_unstemmed | Hydroxypropyl Cellulose/Pluronic-Based Composite Hydrogels as Biodegradable Mucoadhesive Scaffolds for Tissue Engineering |
| title_short | Hydroxypropyl Cellulose/Pluronic-Based Composite Hydrogels as Biodegradable Mucoadhesive Scaffolds for Tissue Engineering |
| title_sort | hydroxypropyl cellulose pluronic based composite hydrogels as biodegradable mucoadhesive scaffolds for tissue engineering |
| topic | hydroxypropyl cellulose polymeric blends dynamic vapor sorption biocompatibility mucoadhesive gels tissue engineering |
| url | https://www.mdpi.com/2310-2861/8/8/519 |
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