The COPD-Associated Polymorphism Impairs the CFTR Function to Suppress Excessive IL-8 Production upon Environmental Pathogen Exposure

The COPD-Associated Polymorphism Impairs the CFTR Function to Suppress Excessive IL-8 Production upon Environmental Pathogen Exposure

COPD is a lifestyle-related disease resulting from irreversible damage to respiratory tissues mostly due to chronic exposure to environmental pollutants, including cigarette smoke. Environmental pathogens and pollutants induce the acquired dysfunction of the CFTR Cl<sup>−</sup> channel,...

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Bibliographic Details
Main Authors: Daichi Hinata, Ryosuke Fukuda, Tsukasa Okiyoneda
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
CFTR
COPD
polymorphism
cystic fibrosis
IL-8
Trikafta
Online Access:https://www.mdpi.com/1422-0067/24/3/2305

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