Loss of Ambra1 promotes melanoma growth and invasion
The absence of scaffold protein Ambra1 leads to hyperproliferation and growth in mouse models. Here the authors show that Ambra1 deficiency accelerates melanoma growth and increases metastasis in mouse models of melanoma through FAK1 hyperactivation.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22772-2 |
| _version_ | 1818994497154973696 |
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| author | Luca Di Leo Valérie Bodemeyer Francesca M. Bosisio Giuseppina Claps Marco Carretta Salvatore Rizza Fiorella Faienza Alex Frias Shawez Khan Matteo Bordi Maria P. Pacheco Julie Di Martino Jose J. Bravo-Cordero Colin J. Daniel Rosalie C. Sears Marco Donia Daniel H. Madsen Per Guldberg Giuseppe Filomeni Thomas Sauter Caroline Robert Daniela De Zio Francesco Cecconi |
| author_facet | Luca Di Leo Valérie Bodemeyer Francesca M. Bosisio Giuseppina Claps Marco Carretta Salvatore Rizza Fiorella Faienza Alex Frias Shawez Khan Matteo Bordi Maria P. Pacheco Julie Di Martino Jose J. Bravo-Cordero Colin J. Daniel Rosalie C. Sears Marco Donia Daniel H. Madsen Per Guldberg Giuseppe Filomeni Thomas Sauter Caroline Robert Daniela De Zio Francesco Cecconi |
| author_sort | Luca Di Leo |
| collection | DOAJ |
| description | The absence of scaffold protein Ambra1 leads to hyperproliferation and growth in mouse models. Here the authors show that Ambra1 deficiency accelerates melanoma growth and increases metastasis in mouse models of melanoma through FAK1 hyperactivation. |
| first_indexed | 2024-12-20T20:58:53Z |
| format | Article |
| id | doaj.art-57c07f6892f24e98b8abf330dfb96699 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:58:53Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-57c07f6892f24e98b8abf330dfb966992022-12-21T19:26:45ZengNature PortfolioNature Communications2041-17232021-05-0112111710.1038/s41467-021-22772-2Loss of Ambra1 promotes melanoma growth and invasionLuca Di Leo0Valérie Bodemeyer1Francesca M. Bosisio2Giuseppina Claps3Marco Carretta4Salvatore Rizza5Fiorella Faienza6Alex Frias7Shawez Khan8Matteo Bordi9Maria P. Pacheco10Julie Di Martino11Jose J. Bravo-Cordero12Colin J. Daniel13Rosalie C. Sears14Marco Donia15Daniel H. Madsen16Per Guldberg17Giuseppe Filomeni18Thomas Sauter19Caroline Robert20Daniela De Zio21Francesco Cecconi22Melanoma Research Team, Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research CenterMelanoma Research Team, Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research CenterLab of Translational Cell and Tissue Research, University of LeuvenINSERM U981, Gustave Roussy InstituteNational Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University HospitalRedox Biology Group, Danish Cancer Society Research CenterDepartment of Biology, University of Rome Tor VergataMelanoma Research Team, Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research CenterNational Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University HospitalDepartment of Pediatric Hematology and Oncology, Bambino Gesù Children’s HospitalLife Sciences Research Unit, University of LuxembourgSchool of Medicine, Division of Hematology and Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount SinaiSchool of Medicine, Division of Hematology and Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount SinaiDepartment of Molecular and Medical Genetics, Oregon Health & Science UniversityDepartment of Molecular and Medical Genetics, Oregon Health & Science UniversityNational Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University HospitalNational Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University HospitalMolecular Diagnostics Group, Danish Cancer Society Research CenterRedox Biology Group, Danish Cancer Society Research CenterLife Sciences Research Unit, University of LuxembourgINSERM U981, Gustave Roussy InstituteMelanoma Research Team, Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research CenterDepartment of Biology, University of Rome Tor VergataThe absence of scaffold protein Ambra1 leads to hyperproliferation and growth in mouse models. Here the authors show that Ambra1 deficiency accelerates melanoma growth and increases metastasis in mouse models of melanoma through FAK1 hyperactivation.https://doi.org/10.1038/s41467-021-22772-2 |
| spellingShingle | Luca Di Leo Valérie Bodemeyer Francesca M. Bosisio Giuseppina Claps Marco Carretta Salvatore Rizza Fiorella Faienza Alex Frias Shawez Khan Matteo Bordi Maria P. Pacheco Julie Di Martino Jose J. Bravo-Cordero Colin J. Daniel Rosalie C. Sears Marco Donia Daniel H. Madsen Per Guldberg Giuseppe Filomeni Thomas Sauter Caroline Robert Daniela De Zio Francesco Cecconi Loss of Ambra1 promotes melanoma growth and invasion Nature Communications |
| title | Loss of Ambra1 promotes melanoma growth and invasion |
| title_full | Loss of Ambra1 promotes melanoma growth and invasion |
| title_fullStr | Loss of Ambra1 promotes melanoma growth and invasion |
| title_full_unstemmed | Loss of Ambra1 promotes melanoma growth and invasion |
| title_short | Loss of Ambra1 promotes melanoma growth and invasion |
| title_sort | loss of ambra1 promotes melanoma growth and invasion |
| url | https://doi.org/10.1038/s41467-021-22772-2 |
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