SERINC Proteins Potentiate Antiviral Type I IFN Induction and Proinflammatory Signaling Pathways

SERINC Proteins Potentiate Antiviral Type I IFN Induction and Proinflammatory Signaling Pathways

T cell SERINC proteins were recently identified as human immunodeficiency virus (HIV) restriction factors that diminish viral infectivity by incorporation into virions. Here we provide evidence that SERINC3 and SERINC5 perform additional antiviral activity by enhancing the type I interferon (IFN-I)...

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Bibliographic Details
Main Authors: Cong Zeng, Abdul A. Waheed, Tianliang Li, Jingyou Yu, Yi-Min Zheng, Jacob Yount, Haitao Wen, Eric O. Freed, Shan-Lu Liu
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Proceedings
Subjects:
SERINC
Type I IFN
NF-B
TRAF6
MAVS
Online Access:https://www.mdpi.com/2504-3900/50/1/51

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