Retroviruses and the Third Synapse
The direct movement of viruses between contacting cells as a mode of dissemination distinct from the release of cell-free virions was hinted at in pioneering experiments first reported almost eighty years ago [1], and confirmed and extended 30 years later [2,3]. This early work was carried out using...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-04-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/2/4/1008/ |
| _version_ | 1811312836458053632 |
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| author | Quentin J. Sattentau |
| author_facet | Quentin J. Sattentau |
| author_sort | Quentin J. Sattentau |
| collection | DOAJ |
| description | The direct movement of viruses between contacting cells as a mode of dissemination distinct from the release of cell-free virions was hinted at in pioneering experiments first reported almost eighty years ago [1], and confirmed and extended 30 years later [2,3]. This early work was carried out using the tools of the time in the absence of the modern cell biological, immunological and virological techniques available today. As such, although many of the basic concepts were established for cell-to-cell spread prior to the discovery of retroviruses, descriptions of the molecular and cellular mechanisms underlying this phenomenon were lacking. Papers from two decades ago revealed that HIV-1 could spread between cultured lymphocytes by cell-to-cell spread [4], proposed that this mechanism of dissemination was substantially more efficient than diffusion-limited spread of cell-free virions [5,6], and suggested that this might be a mechanism of evasion from antibody neutralization [4]. [...] |
| first_indexed | 2024-04-13T10:43:36Z |
| format | Article |
| id | doaj.art-57c32dfedb594c1f8b040b1f8984493e |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-13T10:43:36Z |
| publishDate | 2010-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-57c32dfedb594c1f8b040b1f8984493e2022-12-22T02:49:51ZengMDPI AGViruses1999-49152010-04-01241008101010.3390/v2041008Retroviruses and the Third SynapseQuentin J. SattentauThe direct movement of viruses between contacting cells as a mode of dissemination distinct from the release of cell-free virions was hinted at in pioneering experiments first reported almost eighty years ago [1], and confirmed and extended 30 years later [2,3]. This early work was carried out using the tools of the time in the absence of the modern cell biological, immunological and virological techniques available today. As such, although many of the basic concepts were established for cell-to-cell spread prior to the discovery of retroviruses, descriptions of the molecular and cellular mechanisms underlying this phenomenon were lacking. Papers from two decades ago revealed that HIV-1 could spread between cultured lymphocytes by cell-to-cell spread [4], proposed that this mechanism of dissemination was substantially more efficient than diffusion-limited spread of cell-free virions [5,6], and suggested that this might be a mechanism of evasion from antibody neutralization [4]. [...]http://www.mdpi.com/1999-4915/2/4/1008/n/a |
| spellingShingle | Quentin J. Sattentau Retroviruses and the Third Synapse Viruses n/a |
| title | Retroviruses and the Third Synapse |
| title_full | Retroviruses and the Third Synapse |
| title_fullStr | Retroviruses and the Third Synapse |
| title_full_unstemmed | Retroviruses and the Third Synapse |
| title_short | Retroviruses and the Third Synapse |
| title_sort | retroviruses and the third synapse |
| topic | n/a |
| url | http://www.mdpi.com/1999-4915/2/4/1008/ |
| work_keys_str_mv | AT quentinjsattentau retrovirusesandthethirdsynapse |