Long-Term Outcomes of Perinatal Hypoxia and Asphyxia at an Early School Age
<i>Background and Objectives:</i> Late long-term outcomes of perinatal asphyxia (PA) in school-age are often unclear. To assess long-term outcomes at an early school age in children who had experienced perinatal hypoxia or asphyxia, where therapeutic hypothermia was not applied. <i>...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/9/988 |
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| author | Renata Dzikienė Saulius Lukoševičius Jūratė Laurynaitienė Vitalija Marmienė Irena Nedzelskienė Rasa Tamelienė Inesa Rimdeikienė Aušrelė Kudrevičienė |
| author_facet | Renata Dzikienė Saulius Lukoševičius Jūratė Laurynaitienė Vitalija Marmienė Irena Nedzelskienė Rasa Tamelienė Inesa Rimdeikienė Aušrelė Kudrevičienė |
| author_sort | Renata Dzikienė |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Late long-term outcomes of perinatal asphyxia (PA) in school-age are often unclear. To assess long-term outcomes at an early school age in children who had experienced perinatal hypoxia or asphyxia, where therapeutic hypothermia was not applied. <i>Materials and Methods</i>: The case group children were 8–9-year-old children (<i>n</i> = 32) who were born at full term and experienced hypoxia or asphyxia at birth, where therapeutic hypothermia (TH) was not applied. The control group consisted of 8–9-year-old children (<i>n</i> = 16) born without hypoxia. A structured neurological examination was performed at an early school age. The neuromotor function was assessed using the Gross Motor Function Classification System (GMFCS). Health-related quality-of-life was assessed using the Health Utilities Index (HUI) questionnaire. Intellectual abilities were assessed using the Wechsler Intelligence Scale for Children (WISC). <i>Results:</i> The case group, compared with controls, had significantly (<i>p</i> = 0.002) lower mean [SD] full-scale IQ (87(16.86) vs. 107(12.15)), verbal-scale IQ (89(17.45) vs. 105(11.55)), verbal comprehension index (89(17.36) vs. 105(10.74)), working memory index (89(15.68) vs. 104(11.84)), performance IQ (87(16.51) vs. 108(15.48)) and perceptual organization index (85(15.71) vs. 105(15.93)). We did not find any significant differences in the incidence of disorders of neurological examination, movement abilities and health-related quality of life at an early school age between the case and the control group children. <i>Conclusion:</i> In children who experienced perinatal asphyxia but did not have cerebral paralysis (CP), where therapeutic hypothermia was not applied, cognitive assessment scores at an early school age were significantly lower compared to those in the group of healthy children, and were at a low average level. |
| first_indexed | 2024-03-10T07:26:55Z |
| format | Article |
| id | doaj.art-57c4c7de2d694f9592c8906609ddac14 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T07:26:55Z |
| publishDate | 2021-09-01 |
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| record_format | Article |
| series | Medicina |
| spelling | doaj.art-57c4c7de2d694f9592c8906609ddac142023-11-22T14:09:23ZengMDPI AGMedicina1010-660X1648-91442021-09-0157998810.3390/medicina57090988Long-Term Outcomes of Perinatal Hypoxia and Asphyxia at an Early School AgeRenata Dzikienė0Saulius Lukoševičius1Jūratė Laurynaitienė2Vitalija Marmienė3Irena Nedzelskienė4Rasa Tamelienė5Inesa Rimdeikienė6Aušrelė Kudrevičienė7Department of Neonatology, Lithuanian University of Health Sciences, LT-50009 Kaunas, LithuaniaDepartment of Radiology, Lithuanian University of Health Sciences, LT-50009 Kaunas, LithuaniaDepartment of Neurology, Lithuanian University of Health Sciences, LT-50009 Kaunas, LithuaniaDepartment of Psychiatry, Lithuanian University of Health Sciences, LT-50009 Kaunas, LithuaniaDepartment of Dental and Oral Disease, Lithuanian University of Health Sciences, LT-50009 Kaunas, LithuaniaDepartment of Neonatology, Lithuanian University of Health Sciences, LT-50009 Kaunas, LithuaniaDepartment of Rehabilitation, Lithuanian University of Health Sciences, LT-50009 Kaunas, LithuaniaDepartment of Neonatology, Lithuanian University of Health Sciences, LT-50009 Kaunas, Lithuania<i>Background and Objectives:</i> Late long-term outcomes of perinatal asphyxia (PA) in school-age are often unclear. To assess long-term outcomes at an early school age in children who had experienced perinatal hypoxia or asphyxia, where therapeutic hypothermia was not applied. <i>Materials and Methods</i>: The case group children were 8–9-year-old children (<i>n</i> = 32) who were born at full term and experienced hypoxia or asphyxia at birth, where therapeutic hypothermia (TH) was not applied. The control group consisted of 8–9-year-old children (<i>n</i> = 16) born without hypoxia. A structured neurological examination was performed at an early school age. The neuromotor function was assessed using the Gross Motor Function Classification System (GMFCS). Health-related quality-of-life was assessed using the Health Utilities Index (HUI) questionnaire. Intellectual abilities were assessed using the Wechsler Intelligence Scale for Children (WISC). <i>Results:</i> The case group, compared with controls, had significantly (<i>p</i> = 0.002) lower mean [SD] full-scale IQ (87(16.86) vs. 107(12.15)), verbal-scale IQ (89(17.45) vs. 105(11.55)), verbal comprehension index (89(17.36) vs. 105(10.74)), working memory index (89(15.68) vs. 104(11.84)), performance IQ (87(16.51) vs. 108(15.48)) and perceptual organization index (85(15.71) vs. 105(15.93)). We did not find any significant differences in the incidence of disorders of neurological examination, movement abilities and health-related quality of life at an early school age between the case and the control group children. <i>Conclusion:</i> In children who experienced perinatal asphyxia but did not have cerebral paralysis (CP), where therapeutic hypothermia was not applied, cognitive assessment scores at an early school age were significantly lower compared to those in the group of healthy children, and were at a low average level.https://www.mdpi.com/1648-9144/57/9/988perinatal asphyxialong-term outcomesearly school ageWISC-IIIneonatal hypoxic-ischemic encephalopathy |
| spellingShingle | Renata Dzikienė Saulius Lukoševičius Jūratė Laurynaitienė Vitalija Marmienė Irena Nedzelskienė Rasa Tamelienė Inesa Rimdeikienė Aušrelė Kudrevičienė Long-Term Outcomes of Perinatal Hypoxia and Asphyxia at an Early School Age Medicina perinatal asphyxia long-term outcomes early school age WISC-III neonatal hypoxic-ischemic encephalopathy |
| title | Long-Term Outcomes of Perinatal Hypoxia and Asphyxia at an Early School Age |
| title_full | Long-Term Outcomes of Perinatal Hypoxia and Asphyxia at an Early School Age |
| title_fullStr | Long-Term Outcomes of Perinatal Hypoxia and Asphyxia at an Early School Age |
| title_full_unstemmed | Long-Term Outcomes of Perinatal Hypoxia and Asphyxia at an Early School Age |
| title_short | Long-Term Outcomes of Perinatal Hypoxia and Asphyxia at an Early School Age |
| title_sort | long term outcomes of perinatal hypoxia and asphyxia at an early school age |
| topic | perinatal asphyxia long-term outcomes early school age WISC-III neonatal hypoxic-ischemic encephalopathy |
| url | https://www.mdpi.com/1648-9144/57/9/988 |
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