The Antifungal Activity of Naphthoquinones: An Integrative Review
ABSTRACT Naphthoquinones are the most commonly occurring type of quinones in nature. They are a diverse family of secondary metabolites that occur naturally in plants, lichens and various microorganisms. This subgroup is constantly being expanded through the discovery of new natural products and by...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301187&lng=en&tlng=en |
| _version_ | 1818343816478851072 |
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| author | DÉBORA O. FUTURO PATRICIA G. FERREIRA CAROLINE D. NICOLETTI LUANA P. BORBA-SANTOS FERNANDO C. DA SILVA SONIA ROZENTAL VITOR FRANCISCO FERREIRA |
| author_facet | DÉBORA O. FUTURO PATRICIA G. FERREIRA CAROLINE D. NICOLETTI LUANA P. BORBA-SANTOS FERNANDO C. DA SILVA SONIA ROZENTAL VITOR FRANCISCO FERREIRA |
| author_sort | DÉBORA O. FUTURO |
| collection | DOAJ |
| description | ABSTRACT Naphthoquinones are the most commonly occurring type of quinones in nature. They are a diverse family of secondary metabolites that occur naturally in plants, lichens and various microorganisms. This subgroup is constantly being expanded through the discovery of new natural products and by the synthesis of new compounds via innovative techniques. Interest in quinones and the search for new biological activities within the members of this class have intensified in recent years, as evidenced by the evaluation of the potential antimicrobial activities of quinones. Among fungi of medical interest, yeasts of the genus Candida are of extreme importance due to their high frequency of colonization and infection in humans. The objective of this review is to describe the development of naphthoquinones as antifungals for the treatment of Candida species and to note the most promising compounds. By using certain criteria for selection of publications, 68 reports involving both synthetic and natural naphthoquinones are discussed. The activities of a large number of substances were evaluated against Candida albicans as well as against 7 other species of the genus Candida. The results discussed in this review allowed the identification of 30 naphthoquinones with higher antifungal activities than those of the currently used drugs. |
| first_indexed | 2024-12-13T16:36:36Z |
| format | Article |
| id | doaj.art-57c6a0cd321f49a1bd5453a0667732f7 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-12-13T16:36:36Z |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-57c6a0cd321f49a1bd5453a0667732f72022-12-21T23:38:23ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-2690901 suppl 21187121410.1590/0001-3765201820170815S0001-37652018000301187The Antifungal Activity of Naphthoquinones: An Integrative ReviewDÉBORA O. FUTUROPATRICIA G. FERREIRACAROLINE D. NICOLETTILUANA P. BORBA-SANTOSFERNANDO C. DA SILVASONIA ROZENTALVITOR FRANCISCO FERREIRAABSTRACT Naphthoquinones are the most commonly occurring type of quinones in nature. They are a diverse family of secondary metabolites that occur naturally in plants, lichens and various microorganisms. This subgroup is constantly being expanded through the discovery of new natural products and by the synthesis of new compounds via innovative techniques. Interest in quinones and the search for new biological activities within the members of this class have intensified in recent years, as evidenced by the evaluation of the potential antimicrobial activities of quinones. Among fungi of medical interest, yeasts of the genus Candida are of extreme importance due to their high frequency of colonization and infection in humans. The objective of this review is to describe the development of naphthoquinones as antifungals for the treatment of Candida species and to note the most promising compounds. By using certain criteria for selection of publications, 68 reports involving both synthetic and natural naphthoquinones are discussed. The activities of a large number of substances were evaluated against Candida albicans as well as against 7 other species of the genus Candida. The results discussed in this review allowed the identification of 30 naphthoquinones with higher antifungal activities than those of the currently used drugs.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301187&lng=en&tlng=enQuinonesxantheneslapachollawsoneCandida sppdisc diffusion method |
| spellingShingle | DÉBORA O. FUTURO PATRICIA G. FERREIRA CAROLINE D. NICOLETTI LUANA P. BORBA-SANTOS FERNANDO C. DA SILVA SONIA ROZENTAL VITOR FRANCISCO FERREIRA The Antifungal Activity of Naphthoquinones: An Integrative Review Anais da Academia Brasileira de Ciências Quinones xanthenes lapachol lawsone Candida spp disc diffusion method |
| title | The Antifungal Activity of Naphthoquinones: An Integrative Review |
| title_full | The Antifungal Activity of Naphthoquinones: An Integrative Review |
| title_fullStr | The Antifungal Activity of Naphthoquinones: An Integrative Review |
| title_full_unstemmed | The Antifungal Activity of Naphthoquinones: An Integrative Review |
| title_short | The Antifungal Activity of Naphthoquinones: An Integrative Review |
| title_sort | antifungal activity of naphthoquinones an integrative review |
| topic | Quinones xanthenes lapachol lawsone Candida spp disc diffusion method |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301187&lng=en&tlng=en |
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