Immunotherapy in Metastatic Mucosal Melanoma with Disseminated Intravascular Coagulation: A Case of Success
Mucosal melanoma accounts for 1% of all melanomas. It is more aggressive than cutaneous melanoma, and local excision provides the best disease-free survival. The vast majority of patients eventually develop metastases, with a metastatic pattern independent of the primary tumor site. While studies sh...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2021-01-01
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| Series: | Case Reports in Immunology |
| Online Access: | http://dx.doi.org/10.1155/2021/5516004 |
| _version_ | 1826998826938925056 |
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| author | Helena Luna Pais Paulo Luz Soraia Lobo-Martins André Mansinho Rita Sousa Rita Luís Dolores Presa Daniel Gomes Luís Costa Rita Teixeira de Sousa |
| author_facet | Helena Luna Pais Paulo Luz Soraia Lobo-Martins André Mansinho Rita Sousa Rita Luís Dolores Presa Daniel Gomes Luís Costa Rita Teixeira de Sousa |
| author_sort | Helena Luna Pais |
| collection | DOAJ |
| description | Mucosal melanoma accounts for 1% of all melanomas. It is more aggressive than cutaneous melanoma, and local excision provides the best disease-free survival. The vast majority of patients eventually develop metastases, with a metastatic pattern independent of the primary tumor site. While studies show that BRAF and KIT inhibitors have a role in the management of these patients, the actual treatment focus is on immunotherapy. Herein is described the case of a 79-year-old woman with metastatic mucosal melanoma and bone marrow infiltration causing disseminated intravascular coagulation, who was treated with an immunotherapy combination (anti-CTLA-4 and anti-PD-1 antibodies), achieving complete disease remission. This is the third case of melanoma with disseminated intravascular coagulation at presentation and the second case treated with immunotherapy in the literature, but the only one achieving disease remission. |
| first_indexed | 2024-04-11T20:00:19Z |
| format | Article |
| id | doaj.art-57c79bf15b224a969fb7d2f37ea16c03 |
| institution | Directory Open Access Journal |
| issn | 2090-6609 2090-6617 |
| language | English |
| last_indexed | 2025-02-18T10:21:26Z |
| publishDate | 2021-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Case Reports in Immunology |
| spelling | doaj.art-57c79bf15b224a969fb7d2f37ea16c032024-11-02T05:31:16ZengHindawi LimitedCase Reports in Immunology2090-66092090-66172021-01-01202110.1155/2021/55160045516004Immunotherapy in Metastatic Mucosal Melanoma with Disseminated Intravascular Coagulation: A Case of SuccessHelena Luna Pais0Paulo Luz1Soraia Lobo-Martins2André Mansinho3Rita Sousa4Rita Luís5Dolores Presa6Daniel Gomes7Luís Costa8Rita Teixeira de Sousa9Serviço de Oncologia, Hospital de Santa Maria, CHULN, Lisbon, PortugalServiço de Oncologia, Centro Hospitalar Universitário do Algarve, Faro, PortugalServiço de Oncologia, Hospital de Santa Maria, CHULN, Lisbon, PortugalServiço de Oncologia, Hospital de Santa Maria, CHULN, Lisbon, PortugalServiço de Imagiologia, Hospital de Santa Maria, CHULN, Lisbon, PortugalServiço Anatomia Patológica, Hospital de Santa Maria, CHULN, Lisbon, PortugalServiço Anatomia Patológica, Hospital de Santa Maria, CHULN, Lisbon, PortugalServiço de Medicina Interna, Hospital de Santa Maria, CHULN, Lisbon, PortugalServiço de Oncologia, Hospital de Santa Maria, CHULN, Lisbon, PortugalServiço de Oncologia, Hospital de Santa Maria, CHULN, Lisbon, PortugalMucosal melanoma accounts for 1% of all melanomas. It is more aggressive than cutaneous melanoma, and local excision provides the best disease-free survival. The vast majority of patients eventually develop metastases, with a metastatic pattern independent of the primary tumor site. While studies show that BRAF and KIT inhibitors have a role in the management of these patients, the actual treatment focus is on immunotherapy. Herein is described the case of a 79-year-old woman with metastatic mucosal melanoma and bone marrow infiltration causing disseminated intravascular coagulation, who was treated with an immunotherapy combination (anti-CTLA-4 and anti-PD-1 antibodies), achieving complete disease remission. This is the third case of melanoma with disseminated intravascular coagulation at presentation and the second case treated with immunotherapy in the literature, but the only one achieving disease remission.http://dx.doi.org/10.1155/2021/5516004 |
| spellingShingle | Helena Luna Pais Paulo Luz Soraia Lobo-Martins André Mansinho Rita Sousa Rita Luís Dolores Presa Daniel Gomes Luís Costa Rita Teixeira de Sousa Immunotherapy in Metastatic Mucosal Melanoma with Disseminated Intravascular Coagulation: A Case of Success Case Reports in Immunology |
| title | Immunotherapy in Metastatic Mucosal Melanoma with Disseminated Intravascular Coagulation: A Case of Success |
| title_full | Immunotherapy in Metastatic Mucosal Melanoma with Disseminated Intravascular Coagulation: A Case of Success |
| title_fullStr | Immunotherapy in Metastatic Mucosal Melanoma with Disseminated Intravascular Coagulation: A Case of Success |
| title_full_unstemmed | Immunotherapy in Metastatic Mucosal Melanoma with Disseminated Intravascular Coagulation: A Case of Success |
| title_short | Immunotherapy in Metastatic Mucosal Melanoma with Disseminated Intravascular Coagulation: A Case of Success |
| title_sort | immunotherapy in metastatic mucosal melanoma with disseminated intravascular coagulation a case of success |
| url | http://dx.doi.org/10.1155/2021/5516004 |
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