A physiological model for interpretation of arterial spin labeling reactive hyperemia of calf muscles.
To characterize and interpret arterial spin labeling (ASL) reactive hyperemia of calf muscles for a better understanding of the microcirculation in peripheral arterial disease (PAD), we present a physiological model incorporating oxygen transport, tissue metabolism, and vascular regulation mechanism...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5570335?pdf=render |
| _version_ | 1819122842232422400 |
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| author | Hou-Jen Chen Graham A Wright |
| author_facet | Hou-Jen Chen Graham A Wright |
| author_sort | Hou-Jen Chen |
| collection | DOAJ |
| description | To characterize and interpret arterial spin labeling (ASL) reactive hyperemia of calf muscles for a better understanding of the microcirculation in peripheral arterial disease (PAD), we present a physiological model incorporating oxygen transport, tissue metabolism, and vascular regulation mechanisms. The model demonstrated distinct effects between arterial stenoses and microvascular dysfunction on reactive hyperemia, and indicated a higher sensitivity of 2-minute thigh cuffing to microvascular dysfunction than 5-minute cuffing. The recorded perfusion responses in PAD patients (n = 9) were better differentiated from the normal subjects (n = 7) using the model-based analysis rather than characterization using the apparent peak and time-to-peak of the responses. The analysis results suggested different amounts of microvascular disease within the patient group. Overall, this work demonstrates a novel analysis method and facilitates understanding of the physiology involved in ASL reactive hyperemia. ASL reactive hyperemia with model-based analysis may be used as a noninvasive microvascular assessment in the presence of arterial stenoses, allowing us to look beyond the macrovascular disease in PAD. A subgroup who will have a poor prognosis after revascularization in the patients with critical limb ischemia may be associated with more severe microvascular diseases, which may potentially be identified using ASL reactive hyperemia. |
| first_indexed | 2024-12-22T06:58:53Z |
| format | Article |
| id | doaj.art-57c7aba55bb941038da9fb1ac4ab7d7a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T06:58:53Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-57c7aba55bb941038da9fb1ac4ab7d7a2022-12-21T18:34:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01128e018325910.1371/journal.pone.0183259A physiological model for interpretation of arterial spin labeling reactive hyperemia of calf muscles.Hou-Jen ChenGraham A WrightTo characterize and interpret arterial spin labeling (ASL) reactive hyperemia of calf muscles for a better understanding of the microcirculation in peripheral arterial disease (PAD), we present a physiological model incorporating oxygen transport, tissue metabolism, and vascular regulation mechanisms. The model demonstrated distinct effects between arterial stenoses and microvascular dysfunction on reactive hyperemia, and indicated a higher sensitivity of 2-minute thigh cuffing to microvascular dysfunction than 5-minute cuffing. The recorded perfusion responses in PAD patients (n = 9) were better differentiated from the normal subjects (n = 7) using the model-based analysis rather than characterization using the apparent peak and time-to-peak of the responses. The analysis results suggested different amounts of microvascular disease within the patient group. Overall, this work demonstrates a novel analysis method and facilitates understanding of the physiology involved in ASL reactive hyperemia. ASL reactive hyperemia with model-based analysis may be used as a noninvasive microvascular assessment in the presence of arterial stenoses, allowing us to look beyond the macrovascular disease in PAD. A subgroup who will have a poor prognosis after revascularization in the patients with critical limb ischemia may be associated with more severe microvascular diseases, which may potentially be identified using ASL reactive hyperemia.http://europepmc.org/articles/PMC5570335?pdf=render |
| spellingShingle | Hou-Jen Chen Graham A Wright A physiological model for interpretation of arterial spin labeling reactive hyperemia of calf muscles. PLoS ONE |
| title | A physiological model for interpretation of arterial spin labeling reactive hyperemia of calf muscles. |
| title_full | A physiological model for interpretation of arterial spin labeling reactive hyperemia of calf muscles. |
| title_fullStr | A physiological model for interpretation of arterial spin labeling reactive hyperemia of calf muscles. |
| title_full_unstemmed | A physiological model for interpretation of arterial spin labeling reactive hyperemia of calf muscles. |
| title_short | A physiological model for interpretation of arterial spin labeling reactive hyperemia of calf muscles. |
| title_sort | physiological model for interpretation of arterial spin labeling reactive hyperemia of calf muscles |
| url | http://europepmc.org/articles/PMC5570335?pdf=render |
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