The Same–Up–Down Staging System for Recurrent Early Glottic Cancer
(1) Background: The treatment of recurrent early glottic cancer (rEGC) remains challenging. We wanted to investigate how the oncological outcomes are affected by the initial and recurrent stages, in order to propose our newly developed Same–Up–Down (SUD) staging system. (2) Methods: In our cohort of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/3/598 |
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| author | Giuseppe Licci Luca Giovanni Locatello Giandomenico Maggiore Flavia Cozzolino Saverio Caini Oreste Gallo |
| author_facet | Giuseppe Licci Luca Giovanni Locatello Giandomenico Maggiore Flavia Cozzolino Saverio Caini Oreste Gallo |
| author_sort | Giuseppe Licci |
| collection | DOAJ |
| description | (1) Background: The treatment of recurrent early glottic cancer (rEGC) remains challenging. We wanted to investigate how the oncological outcomes are affected by the initial and recurrent stages, in order to propose our newly developed Same–Up–Down (SUD) staging system. (2) Methods: In our cohort of 258 rEGC patients, we retrospectively assessed the prognostic performances of the rTNM (the TNM staging system for recurrence), CLRSS, CLRSS-2, and SUD staging systems by univariate and multivariate Cox analysis, comparing their predictive capability using Harrell’s C-index. (3) Results: The SUD classification satisfactorily predicted both overall survival (<i>p</i> = 0.022) and second-recurrence-free survival (<i>p</i> = 0.024, as same + down vs. upstage) in our cohort. It also outperformed the other three systems in terms of prediction of survival, with an improvement of 1.52%, 1.18%, and 3.96% in the predictive capacity of overall survival, disease-specific survival, and second-recurrence-free survival, respectively. (4) Conclusions: The SUD staging system can efficiently predict survival in rEGC patients, whose prognosis heavily depends on both the initial and recurrent locoregional extension. |
| first_indexed | 2024-03-11T09:50:58Z |
| format | Article |
| id | doaj.art-57c839388a8e4bb8b056a2546d2d7a47 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:50:58Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-57c839388a8e4bb8b056a2546d2d7a472023-11-16T16:14:29ZengMDPI AGCancers2072-66942023-01-0115359810.3390/cancers15030598The Same–Up–Down Staging System for Recurrent Early Glottic CancerGiuseppe Licci0Luca Giovanni Locatello1Giandomenico Maggiore2Flavia Cozzolino3Saverio Caini4Oreste Gallo5Department of Otorhinolaryngology, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, ItalyDepartment of Otorhinolaryngology, Academic Hospital “Santa Maria della Misericordia”, Azienda Sanitaria Universitaria Friuli Centrale, Piazzale Santa Maria della Misericordia 15, 33100 Udine, ItalyDepartment of Otorhinolaryngology, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, ItalyCancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo il Vecchio 2, 50139 Florence, ItalyCancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo il Vecchio 2, 50139 Florence, ItalyDepartment of Otorhinolaryngology, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy(1) Background: The treatment of recurrent early glottic cancer (rEGC) remains challenging. We wanted to investigate how the oncological outcomes are affected by the initial and recurrent stages, in order to propose our newly developed Same–Up–Down (SUD) staging system. (2) Methods: In our cohort of 258 rEGC patients, we retrospectively assessed the prognostic performances of the rTNM (the TNM staging system for recurrence), CLRSS, CLRSS-2, and SUD staging systems by univariate and multivariate Cox analysis, comparing their predictive capability using Harrell’s C-index. (3) Results: The SUD classification satisfactorily predicted both overall survival (<i>p</i> = 0.022) and second-recurrence-free survival (<i>p</i> = 0.024, as same + down vs. upstage) in our cohort. It also outperformed the other three systems in terms of prediction of survival, with an improvement of 1.52%, 1.18%, and 3.96% in the predictive capacity of overall survival, disease-specific survival, and second-recurrence-free survival, respectively. (4) Conclusions: The SUD staging system can efficiently predict survival in rEGC patients, whose prognosis heavily depends on both the initial and recurrent locoregional extension.https://www.mdpi.com/2072-6694/15/3/598laryngeal cancerglottic cancerrecurrencestagingsquamous-cell carcinoma |
| spellingShingle | Giuseppe Licci Luca Giovanni Locatello Giandomenico Maggiore Flavia Cozzolino Saverio Caini Oreste Gallo The Same–Up–Down Staging System for Recurrent Early Glottic Cancer Cancers laryngeal cancer glottic cancer recurrence staging squamous-cell carcinoma |
| title | The Same–Up–Down Staging System for Recurrent Early Glottic Cancer |
| title_full | The Same–Up–Down Staging System for Recurrent Early Glottic Cancer |
| title_fullStr | The Same–Up–Down Staging System for Recurrent Early Glottic Cancer |
| title_full_unstemmed | The Same–Up–Down Staging System for Recurrent Early Glottic Cancer |
| title_short | The Same–Up–Down Staging System for Recurrent Early Glottic Cancer |
| title_sort | same up down staging system for recurrent early glottic cancer |
| topic | laryngeal cancer glottic cancer recurrence staging squamous-cell carcinoma |
| url | https://www.mdpi.com/2072-6694/15/3/598 |
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