A Clinicopathology Review and Update of Epstein–Barr Virus-Associated Mesenchymal Tumors
The Epstein–Barr virus (EBV) is associated with various tumor types, including nasopharyngeal carcinoma and lymphoproliferative disorders. While much is known about EBV-related epithelial and lymphoid tumors, there is a paucity of knowledge concerning EBV-associated mesenchymal tumors. This review a...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/23/5563 |
| _version_ | 1797400378794311680 |
|---|---|
| author | Oswald Zhao Jian Lee Noorjehan Omar Joshua K. Tay Victor Kwan Min Lee |
| author_facet | Oswald Zhao Jian Lee Noorjehan Omar Joshua K. Tay Victor Kwan Min Lee |
| author_sort | Oswald Zhao Jian Lee |
| collection | DOAJ |
| description | The Epstein–Barr virus (EBV) is associated with various tumor types, including nasopharyngeal carcinoma and lymphoproliferative disorders. While much is known about EBV-related epithelial and lymphoid tumors, there is a paucity of knowledge concerning EBV-associated mesenchymal tumors. This review aims to provide a comprehensive overview of EBV-associated mesenchymal tumors, encompassing their clinical features, pathological characteristics, pathophysiology, prognostic factors, and current treatment approaches. Through an extensive literature search using the PubMed database, we were able to identify three distinct EBV-associated mesenchymal tumors: EBV-associated smooth muscle tumors, inflammatory pseudotumor-like follicular dendritic cell sarcomas, and EBV-associated osteosarcomas. Although this review extensively explored the different aspects of these mesenchymal tumors, our comprehension of the underlying pathophysiology in this context is still incomplete. Therefore, we hope that this review paper will not only serve as a valuable repository of information but also serve as a catalyst for prospective in vitro and in vivo research studies to bridge the existing knowledge gap surrounding pathophysiology, ultimately making an important contribution to shaping future therapeutic approaches. |
| first_indexed | 2024-03-09T01:53:46Z |
| format | Article |
| id | doaj.art-57c94af7b7914db189fb93a25538e949 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T01:53:46Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-57c94af7b7914db189fb93a25538e9492023-12-08T15:12:33ZengMDPI AGCancers2072-66942023-11-011523556310.3390/cancers15235563A Clinicopathology Review and Update of Epstein–Barr Virus-Associated Mesenchymal TumorsOswald Zhao Jian Lee0Noorjehan Omar1Joshua K. Tay2Victor Kwan Min Lee3Department of Pathology, National University Hospital, National University Health System, Singapore 119074, SingaporeDepartment of Pathology, Hospital Serdang, Kajang 43000, MalaysiaDepartment of Otolaryngology—Head and Neck Surgery, National University of Singapore, Singapore 119228, SingaporeDepartment of Pathology, National University Hospital, National University Health System, Singapore 119074, SingaporeThe Epstein–Barr virus (EBV) is associated with various tumor types, including nasopharyngeal carcinoma and lymphoproliferative disorders. While much is known about EBV-related epithelial and lymphoid tumors, there is a paucity of knowledge concerning EBV-associated mesenchymal tumors. This review aims to provide a comprehensive overview of EBV-associated mesenchymal tumors, encompassing their clinical features, pathological characteristics, pathophysiology, prognostic factors, and current treatment approaches. Through an extensive literature search using the PubMed database, we were able to identify three distinct EBV-associated mesenchymal tumors: EBV-associated smooth muscle tumors, inflammatory pseudotumor-like follicular dendritic cell sarcomas, and EBV-associated osteosarcomas. Although this review extensively explored the different aspects of these mesenchymal tumors, our comprehension of the underlying pathophysiology in this context is still incomplete. Therefore, we hope that this review paper will not only serve as a valuable repository of information but also serve as a catalyst for prospective in vitro and in vivo research studies to bridge the existing knowledge gap surrounding pathophysiology, ultimately making an important contribution to shaping future therapeutic approaches.https://www.mdpi.com/2072-6694/15/23/5563Epstein–Barr virus (EBV)mesenchymalsarcomasmooth muscle |
| spellingShingle | Oswald Zhao Jian Lee Noorjehan Omar Joshua K. Tay Victor Kwan Min Lee A Clinicopathology Review and Update of Epstein–Barr Virus-Associated Mesenchymal Tumors Cancers Epstein–Barr virus (EBV) mesenchymal sarcoma smooth muscle |
| title | A Clinicopathology Review and Update of Epstein–Barr Virus-Associated Mesenchymal Tumors |
| title_full | A Clinicopathology Review and Update of Epstein–Barr Virus-Associated Mesenchymal Tumors |
| title_fullStr | A Clinicopathology Review and Update of Epstein–Barr Virus-Associated Mesenchymal Tumors |
| title_full_unstemmed | A Clinicopathology Review and Update of Epstein–Barr Virus-Associated Mesenchymal Tumors |
| title_short | A Clinicopathology Review and Update of Epstein–Barr Virus-Associated Mesenchymal Tumors |
| title_sort | clinicopathology review and update of epstein barr virus associated mesenchymal tumors |
| topic | Epstein–Barr virus (EBV) mesenchymal sarcoma smooth muscle |
| url | https://www.mdpi.com/2072-6694/15/23/5563 |
| work_keys_str_mv | AT oswaldzhaojianlee aclinicopathologyreviewandupdateofepsteinbarrvirusassociatedmesenchymaltumors AT noorjehanomar aclinicopathologyreviewandupdateofepsteinbarrvirusassociatedmesenchymaltumors AT joshuaktay aclinicopathologyreviewandupdateofepsteinbarrvirusassociatedmesenchymaltumors AT victorkwanminlee aclinicopathologyreviewandupdateofepsteinbarrvirusassociatedmesenchymaltumors AT oswaldzhaojianlee clinicopathologyreviewandupdateofepsteinbarrvirusassociatedmesenchymaltumors AT noorjehanomar clinicopathologyreviewandupdateofepsteinbarrvirusassociatedmesenchymaltumors AT joshuaktay clinicopathologyreviewandupdateofepsteinbarrvirusassociatedmesenchymaltumors AT victorkwanminlee clinicopathologyreviewandupdateofepsteinbarrvirusassociatedmesenchymaltumors |