Albendazole increases serum retinol concentration in primary schoolchildren with low serum retinol
Background Soil-transmitted helminth (STH) infection is still a health problem in Indonesia. Vitamin A deficiency (VAD) is often found together with STH. The effect of the deworming program on the vitamin A status of primary school children is unknown. The objective of this study was to evaluate th...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine Trisakti University
2015-08-01
|
| Series: | Universa Medicina |
| Subjects: | |
| Online Access: | http://www.univmed.org/wp-content/uploads/2015/09/Jane1.pdf |
| _version_ | 1818643627580063744 |
|---|---|
| author | Jane Florida Kalumpiu Yenny Djuardi Taniawati Supali Ria Buana |
| author_facet | Jane Florida Kalumpiu Yenny Djuardi Taniawati Supali Ria Buana |
| author_sort | Jane Florida Kalumpiu |
| collection | DOAJ |
| description | Background
Soil-transmitted helminth (STH) infection is still a health problem in Indonesia. Vitamin A deficiency (VAD) is often found together with STH. The effect of the deworming program on the vitamin A status of primary school children is unknown. The objective of this study was to evaluate the effect of albendazole on serum retinol concentrations in primary school children.
Methods
An experimental study of pre-post test design without control was carried out on 118 children from grades 3-5 at one primary school in North Jakarta, from July to September 2014. Flotac examination was used to determine STH infections and high performance liquid chromatography was performed to measure serum retinol concentration. Stool and blood samples were taken twice: before and three weeks after treatment with albendazole 400 mg single dose for three consecutive days given to all children either infected or uninfected. Paired t-test was used to analyze the data.
Results
Of the 118 children, the prevalence of STH was 71.2%. The prevalence of low retinol serum (<1.05 mmol/L) was 17 (17.2%) and of mild VAD was 2 (2.0%). Albendazole given in 3 consecutive days could not increase serum retinol concentrations (p=0.055). Serum retinol concentration significantly increased after albendazole treatment in children with low retinol serum at baseline (p=0.001).
Conclusions
In children with low serum retinol concentration, treatment with albendazole increased retinol concentration. Integrated deworming and vitamin A supplementation strategies should be evaluated in this population. |
| first_indexed | 2024-12-17T00:01:58Z |
| format | Article |
| id | doaj.art-57cabb298c9a4f98b6666e4ebbf9b803 |
| institution | Directory Open Access Journal |
| issn | 1907-3062 |
| language | English |
| last_indexed | 2024-12-17T00:01:58Z |
| publishDate | 2015-08-01 |
| publisher | Faculty of Medicine Trisakti University |
| record_format | Article |
| series | Universa Medicina |
| spelling | doaj.art-57cabb298c9a4f98b6666e4ebbf9b8032022-12-21T22:11:04ZengFaculty of Medicine Trisakti UniversityUniversa Medicina1907-30622015-08-0134212112810.18051/UnivMed.2015.v34.121Albendazole increases serum retinol concentration in primary schoolchildren with low serum retinolJane Florida Kalumpiu0Yenny Djuardi1Taniawati Supali2Ria Buana3Department of Parasitology, Faculty of Medicine, Trisakti UniversityDepartment of Parasitology, Faculty of Medicine, University of IndonesiaDepartment of Parasitology, Faculty of Medicine, University of IndonesiaBiomedical Sciences Master Program, Faculty of Medicine, University of IndonesiaBackground Soil-transmitted helminth (STH) infection is still a health problem in Indonesia. Vitamin A deficiency (VAD) is often found together with STH. The effect of the deworming program on the vitamin A status of primary school children is unknown. The objective of this study was to evaluate the effect of albendazole on serum retinol concentrations in primary school children. Methods An experimental study of pre-post test design without control was carried out on 118 children from grades 3-5 at one primary school in North Jakarta, from July to September 2014. Flotac examination was used to determine STH infections and high performance liquid chromatography was performed to measure serum retinol concentration. Stool and blood samples were taken twice: before and three weeks after treatment with albendazole 400 mg single dose for three consecutive days given to all children either infected or uninfected. Paired t-test was used to analyze the data. Results Of the 118 children, the prevalence of STH was 71.2%. The prevalence of low retinol serum (<1.05 mmol/L) was 17 (17.2%) and of mild VAD was 2 (2.0%). Albendazole given in 3 consecutive days could not increase serum retinol concentrations (p=0.055). Serum retinol concentration significantly increased after albendazole treatment in children with low retinol serum at baseline (p=0.001). Conclusions In children with low serum retinol concentration, treatment with albendazole increased retinol concentration. Integrated deworming and vitamin A supplementation strategies should be evaluated in this population.http://www.univmed.org/wp-content/uploads/2015/09/Jane1.pdfAlbendazoleretinolvitamin A statusprimary schoolchildren |
| spellingShingle | Jane Florida Kalumpiu Yenny Djuardi Taniawati Supali Ria Buana Albendazole increases serum retinol concentration in primary schoolchildren with low serum retinol Universa Medicina Albendazole retinol vitamin A status primary schoolchildren |
| title | Albendazole increases serum retinol concentration in primary schoolchildren with low serum retinol |
| title_full | Albendazole increases serum retinol concentration in primary schoolchildren with low serum retinol |
| title_fullStr | Albendazole increases serum retinol concentration in primary schoolchildren with low serum retinol |
| title_full_unstemmed | Albendazole increases serum retinol concentration in primary schoolchildren with low serum retinol |
| title_short | Albendazole increases serum retinol concentration in primary schoolchildren with low serum retinol |
| title_sort | albendazole increases serum retinol concentration in primary schoolchildren with low serum retinol |
| topic | Albendazole retinol vitamin A status primary schoolchildren |
| url | http://www.univmed.org/wp-content/uploads/2015/09/Jane1.pdf |
| work_keys_str_mv | AT janefloridakalumpiu albendazoleincreasesserumretinolconcentrationinprimaryschoolchildrenwithlowserumretinol AT yennydjuardi albendazoleincreasesserumretinolconcentrationinprimaryschoolchildrenwithlowserumretinol AT taniawatisupali albendazoleincreasesserumretinolconcentrationinprimaryschoolchildrenwithlowserumretinol AT riabuana albendazoleincreasesserumretinolconcentrationinprimaryschoolchildrenwithlowserumretinol |