Primary Resistance to Immunotherapy-Based Regimens in First Line Hepatocellular Carcinoma: Perspectives on Jumping the Hurdle

Primary Resistance to Immunotherapy-Based Regimens in First Line Hepatocellular Carcinoma: Perspectives on Jumping the Hurdle

Immune checkpoint inhibitors (ICIs) are a key component of different stages of hepatocellular carcinoma (HCC) treatment, particularly in the first line of treatment. A lesson on the primary resistance which hampers their efficacy and activity was learned from the failure of the trials which tested t...

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Bibliographic Details
Main Authors: Francesca Salani, Virginia Genovesi, Caterina Vivaldi, Valentina Massa, Silvia Cesario, Laura Bernardini, Miriam Caccese, Jessica Graziani, Dario Berra, Lorenzo Fornaro, Gianluca Masi
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
immune-checkpoint inhibitors (ICIs)
advanced hepatocellular carcinoma (aHCC)
first line
primary resistance
primary progressors
TIGIT
Online Access:https://www.mdpi.com/2072-6694/14/19/4896

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