The circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice.
Cardiac function is highly dependent on oxidative energy, which is produced by mitochondrial respiration. Defects in mitochondrial function are associated with both structural and functional abnormalities in the heart. Here, we show that heart-specific ablation of the circadian clock gene Bmal1 resu...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4229239?pdf=render |
| _version_ | 1819130223696805888 |
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| author | Akira Kohsaka Partha Das Izumi Hashimoto Tomomi Nakao Yoko Deguchi Sabine S Gouraud Hidefumi Waki Yasuteru Muragaki Masanobu Maeda |
| author_facet | Akira Kohsaka Partha Das Izumi Hashimoto Tomomi Nakao Yoko Deguchi Sabine S Gouraud Hidefumi Waki Yasuteru Muragaki Masanobu Maeda |
| author_sort | Akira Kohsaka |
| collection | DOAJ |
| description | Cardiac function is highly dependent on oxidative energy, which is produced by mitochondrial respiration. Defects in mitochondrial function are associated with both structural and functional abnormalities in the heart. Here, we show that heart-specific ablation of the circadian clock gene Bmal1 results in cardiac mitochondrial defects that include morphological changes and functional abnormalities, such as reduced enzymatic activities within the respiratory complex. Mice without cardiac Bmal1 function show a significant decrease in the expression of genes associated with the fatty acid oxidative pathway, the tricarboxylic acid cycle, and the mitochondrial respiratory chain in the heart and develop severe progressive heart failure with age. Importantly, similar changes in gene expression related to mitochondrial oxidative metabolism are also observed in C57BL/6J mice subjected to chronic reversal of the light-dark cycle; thus, they show disrupted circadian rhythmicity. These findings indicate that the circadian clock system plays an important role in regulating mitochondrial metabolism and thereby maintains cardiac function. |
| first_indexed | 2024-12-22T08:56:12Z |
| format | Article |
| id | doaj.art-57cb852a3bc348419b44d101f05f44ee |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T08:56:12Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-57cb852a3bc348419b44d101f05f44ee2022-12-21T18:31:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e11281110.1371/journal.pone.0112811The circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice.Akira KohsakaPartha DasIzumi HashimotoTomomi NakaoYoko DeguchiSabine S GouraudHidefumi WakiYasuteru MuragakiMasanobu MaedaCardiac function is highly dependent on oxidative energy, which is produced by mitochondrial respiration. Defects in mitochondrial function are associated with both structural and functional abnormalities in the heart. Here, we show that heart-specific ablation of the circadian clock gene Bmal1 results in cardiac mitochondrial defects that include morphological changes and functional abnormalities, such as reduced enzymatic activities within the respiratory complex. Mice without cardiac Bmal1 function show a significant decrease in the expression of genes associated with the fatty acid oxidative pathway, the tricarboxylic acid cycle, and the mitochondrial respiratory chain in the heart and develop severe progressive heart failure with age. Importantly, similar changes in gene expression related to mitochondrial oxidative metabolism are also observed in C57BL/6J mice subjected to chronic reversal of the light-dark cycle; thus, they show disrupted circadian rhythmicity. These findings indicate that the circadian clock system plays an important role in regulating mitochondrial metabolism and thereby maintains cardiac function.http://europepmc.org/articles/PMC4229239?pdf=render |
| spellingShingle | Akira Kohsaka Partha Das Izumi Hashimoto Tomomi Nakao Yoko Deguchi Sabine S Gouraud Hidefumi Waki Yasuteru Muragaki Masanobu Maeda The circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice. PLoS ONE |
| title | The circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice. |
| title_full | The circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice. |
| title_fullStr | The circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice. |
| title_full_unstemmed | The circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice. |
| title_short | The circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice. |
| title_sort | circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice |
| url | http://europepmc.org/articles/PMC4229239?pdf=render |
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