| Summary: | In this study, magnetic graphene oxide (MGO) nanohybrids were first prepared by loading Fe<sub>3</sub>O<sub>4</sub> NPs onto graphene oxide (GO). Then, GS-MGO nanohybrids were prepared by grafting gentamicin sulfate (GS) onto MGO directly using a simple amidation reaction. The prepared GS-MGO had the same magnetism as MGO. They exhibited excellent antibacterial ability against Gram-negative bacteria and Gram-positive bacteria. The GS-MGO had excellent antibacterial performance against <i>Escherichia coli</i> (<i>E. coli</i>), <i>Staphylococcus aureus</i> (<i>S. aureus</i>), and <i>Listeria monocytogenes</i> (<i>L. monocytogenes</i>). When the addition concentration of GS-MGO was 1.25 mg/mL, the calculated bacteriostatic ratios against <i>E. coli</i> and <i>S. aureus</i> achieved 89.8% and 100%, respectively. For <i>L. monocytogenes</i>, only 0.05 mg/mL of GS-MGO had an antibacterial ratio as high as 99%. In addition, the prepared GS-MGO nanohybrids also exhibited excellent non-leaching activity with good recycling antibacterial ability. After eight times antibacterial tests, GS-MGO nanohybrids still exhibited an excellent inhibition effect on <i>E. coli</i>, <i>S. aureus,</i> and <i>L. monocytogenes</i>. Therefore, as a non-leaching antibacterial agent, the fabricated GS-MGO nanohybrid had dramatic antibacterial properties and also showed great recycling ability. Thus, it displayed great potential in the design of novel recycling antibacterial agents with non-leaching activity.
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