Gentamicin Sulfate Grafted Magnetic GO Nanohybrids with Excellent Antibacterial Properties and Recyclability
In this study, magnetic graphene oxide (MGO) nanohybrids were first prepared by loading Fe<sub>3</sub>O<sub>4</sub> NPs onto graphene oxide (GO). Then, GS-MGO nanohybrids were prepared by grafting gentamicin sulfate (GS) onto MGO directly using a simple amidation reaction. Th...
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MDPI AG
2023-04-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/13/8/1416 |
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| author | Xing Wu Jingya Zhou Zeng Liu Wei Shao |
| author_facet | Xing Wu Jingya Zhou Zeng Liu Wei Shao |
| author_sort | Xing Wu |
| collection | DOAJ |
| description | In this study, magnetic graphene oxide (MGO) nanohybrids were first prepared by loading Fe<sub>3</sub>O<sub>4</sub> NPs onto graphene oxide (GO). Then, GS-MGO nanohybrids were prepared by grafting gentamicin sulfate (GS) onto MGO directly using a simple amidation reaction. The prepared GS-MGO had the same magnetism as MGO. They exhibited excellent antibacterial ability against Gram-negative bacteria and Gram-positive bacteria. The GS-MGO had excellent antibacterial performance against <i>Escherichia coli</i> (<i>E. coli</i>), <i>Staphylococcus aureus</i> (<i>S. aureus</i>), and <i>Listeria monocytogenes</i> (<i>L. monocytogenes</i>). When the addition concentration of GS-MGO was 1.25 mg/mL, the calculated bacteriostatic ratios against <i>E. coli</i> and <i>S. aureus</i> achieved 89.8% and 100%, respectively. For <i>L. monocytogenes</i>, only 0.05 mg/mL of GS-MGO had an antibacterial ratio as high as 99%. In addition, the prepared GS-MGO nanohybrids also exhibited excellent non-leaching activity with good recycling antibacterial ability. After eight times antibacterial tests, GS-MGO nanohybrids still exhibited an excellent inhibition effect on <i>E. coli</i>, <i>S. aureus,</i> and <i>L. monocytogenes</i>. Therefore, as a non-leaching antibacterial agent, the fabricated GS-MGO nanohybrid had dramatic antibacterial properties and also showed great recycling ability. Thus, it displayed great potential in the design of novel recycling antibacterial agents with non-leaching activity. |
| first_indexed | 2024-03-11T04:40:19Z |
| format | Article |
| id | doaj.art-57cc6fb74138454cb628ddd8c9bad37b |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-11T04:40:19Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-57cc6fb74138454cb628ddd8c9bad37b2023-11-17T20:44:10ZengMDPI AGNanomaterials2079-49912023-04-01138141610.3390/nano13081416Gentamicin Sulfate Grafted Magnetic GO Nanohybrids with Excellent Antibacterial Properties and RecyclabilityXing Wu0Jingya Zhou1Zeng Liu2Wei Shao3Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, ChinaJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, ChinaJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, ChinaJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, ChinaIn this study, magnetic graphene oxide (MGO) nanohybrids were first prepared by loading Fe<sub>3</sub>O<sub>4</sub> NPs onto graphene oxide (GO). Then, GS-MGO nanohybrids were prepared by grafting gentamicin sulfate (GS) onto MGO directly using a simple amidation reaction. The prepared GS-MGO had the same magnetism as MGO. They exhibited excellent antibacterial ability against Gram-negative bacteria and Gram-positive bacteria. The GS-MGO had excellent antibacterial performance against <i>Escherichia coli</i> (<i>E. coli</i>), <i>Staphylococcus aureus</i> (<i>S. aureus</i>), and <i>Listeria monocytogenes</i> (<i>L. monocytogenes</i>). When the addition concentration of GS-MGO was 1.25 mg/mL, the calculated bacteriostatic ratios against <i>E. coli</i> and <i>S. aureus</i> achieved 89.8% and 100%, respectively. For <i>L. monocytogenes</i>, only 0.05 mg/mL of GS-MGO had an antibacterial ratio as high as 99%. In addition, the prepared GS-MGO nanohybrids also exhibited excellent non-leaching activity with good recycling antibacterial ability. After eight times antibacterial tests, GS-MGO nanohybrids still exhibited an excellent inhibition effect on <i>E. coli</i>, <i>S. aureus,</i> and <i>L. monocytogenes</i>. Therefore, as a non-leaching antibacterial agent, the fabricated GS-MGO nanohybrid had dramatic antibacterial properties and also showed great recycling ability. Thus, it displayed great potential in the design of novel recycling antibacterial agents with non-leaching activity.https://www.mdpi.com/2079-4991/13/8/1416magneticgraphene oxidegentamicin sulfateantibacterialrecyclable activity |
| spellingShingle | Xing Wu Jingya Zhou Zeng Liu Wei Shao Gentamicin Sulfate Grafted Magnetic GO Nanohybrids with Excellent Antibacterial Properties and Recyclability Nanomaterials magnetic graphene oxide gentamicin sulfate antibacterial recyclable activity |
| title | Gentamicin Sulfate Grafted Magnetic GO Nanohybrids with Excellent Antibacterial Properties and Recyclability |
| title_full | Gentamicin Sulfate Grafted Magnetic GO Nanohybrids with Excellent Antibacterial Properties and Recyclability |
| title_fullStr | Gentamicin Sulfate Grafted Magnetic GO Nanohybrids with Excellent Antibacterial Properties and Recyclability |
| title_full_unstemmed | Gentamicin Sulfate Grafted Magnetic GO Nanohybrids with Excellent Antibacterial Properties and Recyclability |
| title_short | Gentamicin Sulfate Grafted Magnetic GO Nanohybrids with Excellent Antibacterial Properties and Recyclability |
| title_sort | gentamicin sulfate grafted magnetic go nanohybrids with excellent antibacterial properties and recyclability |
| topic | magnetic graphene oxide gentamicin sulfate antibacterial recyclable activity |
| url | https://www.mdpi.com/2079-4991/13/8/1416 |
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