Gene–Nutrient Interactions in Obesity: <i>COBLL1</i> Genetic Variants Interact with Dietary Fat Intake to Modulate the Incidence of Obesity
The <i>COBLL1</i> gene is associated with leptin, a hormone important for appetite and weight maintenance. Dietary fat is a significant factor in obesity. This study aimed to determine the association between <i>COBLL1</i> gene, dietary fat, and incidence of obesity. Data fro...
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/4/3758 |
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| author | Junkyung Kwak Dayeon Shin |
| author_facet | Junkyung Kwak Dayeon Shin |
| author_sort | Junkyung Kwak |
| collection | DOAJ |
| description | The <i>COBLL1</i> gene is associated with leptin, a hormone important for appetite and weight maintenance. Dietary fat is a significant factor in obesity. This study aimed to determine the association between <i>COBLL1</i> gene, dietary fat, and incidence of obesity. Data from the Korean Genome and Epidemiology Study were used, and 3055 Korean adults aged ≥ 40 years were included. Obesity was defined as a body mass index ≥ 25 kg/m<sup>2</sup>. Patients with obesity at baseline were excluded. The effects of the <i>COBLL1</i> rs6717858 genotypes and dietary fat on incidence of obesity were evaluated using multivariable Cox proportional hazard models. During an average follow-up period of 9.2 years, 627 obesity cases were documented. In men, the hazard ratio (HR) for obesity was higher in CT, CC carriers (minor allele carriers) in the highest tertile of dietary fat intake than for men with TT carriers in the lowest tertile of dietary fat intake (Model 1: HR: 1.66, 95% confidence interval [CI]: 1.07–2.58; Model 2: HR: 1.63, 95% CI: 1.04–2.56). In women, the HR for obesity was higher in TT carriers in the highest tertile of dietary fat intake than for women with TT carriers in the lowest tertile of dietary fat intake (Model 1: HR: 1.49, 95% CI: 1.08–2.06; Model 2: HR: 1.53, 95% CI: 1.10–2.13). <i>COBLL1</i> genetic variants and dietary fat intake had different sex-dependent effects in obesity. These results imply that a low-fat diet may protect against the effects of <i>COBLL1</i> genetic variants on future obesity risk. |
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| language | English |
| last_indexed | 2024-03-11T08:41:49Z |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-57cd07059493438b9f73c37bd3734d9a2023-11-16T21:04:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244375810.3390/ijms24043758Gene–Nutrient Interactions in Obesity: <i>COBLL1</i> Genetic Variants Interact with Dietary Fat Intake to Modulate the Incidence of ObesityJunkyung Kwak0Dayeon Shin1Department of Food and Nutrition, Inha University, Incheon 22212, Republic of KoreaDepartment of Food and Nutrition, Inha University, Incheon 22212, Republic of KoreaThe <i>COBLL1</i> gene is associated with leptin, a hormone important for appetite and weight maintenance. Dietary fat is a significant factor in obesity. This study aimed to determine the association between <i>COBLL1</i> gene, dietary fat, and incidence of obesity. Data from the Korean Genome and Epidemiology Study were used, and 3055 Korean adults aged ≥ 40 years were included. Obesity was defined as a body mass index ≥ 25 kg/m<sup>2</sup>. Patients with obesity at baseline were excluded. The effects of the <i>COBLL1</i> rs6717858 genotypes and dietary fat on incidence of obesity were evaluated using multivariable Cox proportional hazard models. During an average follow-up period of 9.2 years, 627 obesity cases were documented. In men, the hazard ratio (HR) for obesity was higher in CT, CC carriers (minor allele carriers) in the highest tertile of dietary fat intake than for men with TT carriers in the lowest tertile of dietary fat intake (Model 1: HR: 1.66, 95% confidence interval [CI]: 1.07–2.58; Model 2: HR: 1.63, 95% CI: 1.04–2.56). In women, the HR for obesity was higher in TT carriers in the highest tertile of dietary fat intake than for women with TT carriers in the lowest tertile of dietary fat intake (Model 1: HR: 1.49, 95% CI: 1.08–2.06; Model 2: HR: 1.53, 95% CI: 1.10–2.13). <i>COBLL1</i> genetic variants and dietary fat intake had different sex-dependent effects in obesity. These results imply that a low-fat diet may protect against the effects of <i>COBLL1</i> genetic variants on future obesity risk.https://www.mdpi.com/1422-0067/24/4/3758<i>COBLL1</i>rs6717858obesitydietary fatKorean genome and epidemiology study |
| spellingShingle | Junkyung Kwak Dayeon Shin Gene–Nutrient Interactions in Obesity: <i>COBLL1</i> Genetic Variants Interact with Dietary Fat Intake to Modulate the Incidence of Obesity International Journal of Molecular Sciences <i>COBLL1</i> rs6717858 obesity dietary fat Korean genome and epidemiology study |
| title | Gene–Nutrient Interactions in Obesity: <i>COBLL1</i> Genetic Variants Interact with Dietary Fat Intake to Modulate the Incidence of Obesity |
| title_full | Gene–Nutrient Interactions in Obesity: <i>COBLL1</i> Genetic Variants Interact with Dietary Fat Intake to Modulate the Incidence of Obesity |
| title_fullStr | Gene–Nutrient Interactions in Obesity: <i>COBLL1</i> Genetic Variants Interact with Dietary Fat Intake to Modulate the Incidence of Obesity |
| title_full_unstemmed | Gene–Nutrient Interactions in Obesity: <i>COBLL1</i> Genetic Variants Interact with Dietary Fat Intake to Modulate the Incidence of Obesity |
| title_short | Gene–Nutrient Interactions in Obesity: <i>COBLL1</i> Genetic Variants Interact with Dietary Fat Intake to Modulate the Incidence of Obesity |
| title_sort | gene nutrient interactions in obesity i cobll1 i genetic variants interact with dietary fat intake to modulate the incidence of obesity |
| topic | <i>COBLL1</i> rs6717858 obesity dietary fat Korean genome and epidemiology study |
| url | https://www.mdpi.com/1422-0067/24/4/3758 |
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