Disorders of cancer metabolism: The therapeutic potential of cannabinoids
Abnormal energy metabolism, as one of the important hallmarks of cancer, was induced by multiple carcinogenic factors and tumor-specific microenvironments. It comprises aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis. Considering that metabolic reprogramming provi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222013828 |
| _version_ | 1811187832801198080 |
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| author | Dingya Sun Xin Li Shengdan Nie Jiajia Liu Shan Wang |
| author_facet | Dingya Sun Xin Li Shengdan Nie Jiajia Liu Shan Wang |
| author_sort | Dingya Sun |
| collection | DOAJ |
| description | Abnormal energy metabolism, as one of the important hallmarks of cancer, was induced by multiple carcinogenic factors and tumor-specific microenvironments. It comprises aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis. Considering that metabolic reprogramming provides various nutrients for tumor survival and development, it has been considered a potential target for cancer therapy. Cannabinoids have been shown to exhibit a variety of anticancer activities by unclear mechanisms. This paper first reviews the recent progress of related signaling pathways (reactive oxygen species (ROS), AMP-activated protein kinase (AMPK), mitogen-activated protein kinases (MAPK), phosphoinositide 3-kinase (PI3K), hypoxia-inducible factor-1alpha (HIF-1α), and p53) mediating the reprogramming of cancer metabolism (including glucose metabolism, lipid metabolism, and amino acid metabolism). Then we comprehensively explore the latest discoveries and possible mechanisms of the anticancer effects of cannabinoids through the regulation of the above-mentioned related signaling pathways, to provide new targets and insights for cancer prevention and treatment. |
| first_indexed | 2024-04-11T14:10:11Z |
| format | Article |
| id | doaj.art-57cf9eca2a414939862e5ab560f70491 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-11T14:10:11Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-57cf9eca2a414939862e5ab560f704912022-12-22T04:19:45ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-01-01157113993Disorders of cancer metabolism: The therapeutic potential of cannabinoidsDingya Sun0Xin Li1Shengdan Nie2Jiajia Liu3Shan Wang4Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, ChinaHunan key laboratory of the research and development of novel pharmaceutical preparations, Changsha Medical University, Changsha, ChinaOffice of Drug Clinical Trial Organization, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China; Corresponding authors.Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, China; Corresponding authors.Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, China; Corresponding authors.Abnormal energy metabolism, as one of the important hallmarks of cancer, was induced by multiple carcinogenic factors and tumor-specific microenvironments. It comprises aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis. Considering that metabolic reprogramming provides various nutrients for tumor survival and development, it has been considered a potential target for cancer therapy. Cannabinoids have been shown to exhibit a variety of anticancer activities by unclear mechanisms. This paper first reviews the recent progress of related signaling pathways (reactive oxygen species (ROS), AMP-activated protein kinase (AMPK), mitogen-activated protein kinases (MAPK), phosphoinositide 3-kinase (PI3K), hypoxia-inducible factor-1alpha (HIF-1α), and p53) mediating the reprogramming of cancer metabolism (including glucose metabolism, lipid metabolism, and amino acid metabolism). Then we comprehensively explore the latest discoveries and possible mechanisms of the anticancer effects of cannabinoids through the regulation of the above-mentioned related signaling pathways, to provide new targets and insights for cancer prevention and treatment.http://www.sciencedirect.com/science/article/pii/S0753332222013828CancerCancer metabolismGlycolysisCannabinoidsMetabolic reprogrammingDrug targets |
| spellingShingle | Dingya Sun Xin Li Shengdan Nie Jiajia Liu Shan Wang Disorders of cancer metabolism: The therapeutic potential of cannabinoids Biomedicine & Pharmacotherapy Cancer Cancer metabolism Glycolysis Cannabinoids Metabolic reprogramming Drug targets |
| title | Disorders of cancer metabolism: The therapeutic potential of cannabinoids |
| title_full | Disorders of cancer metabolism: The therapeutic potential of cannabinoids |
| title_fullStr | Disorders of cancer metabolism: The therapeutic potential of cannabinoids |
| title_full_unstemmed | Disorders of cancer metabolism: The therapeutic potential of cannabinoids |
| title_short | Disorders of cancer metabolism: The therapeutic potential of cannabinoids |
| title_sort | disorders of cancer metabolism the therapeutic potential of cannabinoids |
| topic | Cancer Cancer metabolism Glycolysis Cannabinoids Metabolic reprogramming Drug targets |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222013828 |
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