Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer’s disease patients

Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer’s disease patients

Abstract Background Pyroglutamylation of truncated Aβ peptides, which is catalysed by enzyme glutaminyl cyclase (QC), generates pE-Aβ species with enhanced aggregation propensities and resistance to most amino-peptidases and endo-peptidases. pE-Aβ species have been identified as major constituents o...

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Bibliographic Details
Main Authors: Claire Bridel, Torsten Hoffmann, Antje Meyer, Sisi Durieux, Marleen A. Koel-Simmelink, Matthias Orth, Philip Scheltens, Inge Lues, Charlotte E. Teunissen
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Cerebrospinal fluid
Glutaminyl cyclase
Amyloid beta
3pE-Aβ42
Online Access:http://link.springer.com/article/10.1186/s13195-017-0266-6

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