Understanding the heterogeneous immune repertoire of brain metastases for designing next‐gen therapeutics
Abstract Approximately 20% of cancer patients experience brain metastases in the advanced stages as circulating tumor cells migrate to and colonize the brain microvasculature. Due to the challenges associated with biopsies, our understanding of the tumor microenvironment and heterogeneity in brain m...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | Brain-X |
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| Online Access: | https://doi.org/10.1002/brx2.33 |
| _version_ | 1827299906791931904 |
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| author | Zongjie Wang Kangfu Chen |
| author_facet | Zongjie Wang Kangfu Chen |
| author_sort | Zongjie Wang |
| collection | DOAJ |
| description | Abstract Approximately 20% of cancer patients experience brain metastases in the advanced stages as circulating tumor cells migrate to and colonize the brain microvasculature. Due to the challenges associated with biopsies, our understanding of the tumor microenvironment and heterogeneity in brain metastases remains limited, hindering the development of systemic approaches for detection and treatment. Emerging evidence suggests that specific brain metastases induce a substantial level of immune activation and infiltration, which provides an opportunity to design specific immunotherapies targeting brain metastases. This perspective aims to summarize recent advancements in molecular profiling of the immune repertoires of brain metastases using biopsy‐based approaches, with an emphasis on tumor‐reactive T cells. Additionally, we discuss the potential of alternative tissues and technologies that offer improved temporal resolution, throughput, and fidelity for tracking tumor dynamics. |
| first_indexed | 2024-04-24T15:41:40Z |
| format | Article |
| id | doaj.art-57cfee76e3bb42e793a97a0c75dd6bb3 |
| institution | Directory Open Access Journal |
| issn | 2835-3153 |
| language | English |
| last_indexed | 2024-04-24T15:41:40Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain-X |
| spelling | doaj.art-57cfee76e3bb42e793a97a0c75dd6bb32024-04-01T19:00:07ZengWileyBrain-X2835-31532023-09-0113n/an/a10.1002/brx2.33Understanding the heterogeneous immune repertoire of brain metastases for designing next‐gen therapeuticsZongjie Wang0Kangfu Chen1Department of Pharmaceutical Sciences Leslie Dan Faculty of Pharmacy University of Toronto Toronto Ontario CanadaDepartment of Pharmaceutical Sciences Leslie Dan Faculty of Pharmacy University of Toronto Toronto Ontario CanadaAbstract Approximately 20% of cancer patients experience brain metastases in the advanced stages as circulating tumor cells migrate to and colonize the brain microvasculature. Due to the challenges associated with biopsies, our understanding of the tumor microenvironment and heterogeneity in brain metastases remains limited, hindering the development of systemic approaches for detection and treatment. Emerging evidence suggests that specific brain metastases induce a substantial level of immune activation and infiltration, which provides an opportunity to design specific immunotherapies targeting brain metastases. This perspective aims to summarize recent advancements in molecular profiling of the immune repertoires of brain metastases using biopsy‐based approaches, with an emphasis on tumor‐reactive T cells. Additionally, we discuss the potential of alternative tissues and technologies that offer improved temporal resolution, throughput, and fidelity for tracking tumor dynamics.https://doi.org/10.1002/brx2.33brain tumorcell therapyimmune profilingimmunotherapymetastasis |
| spellingShingle | Zongjie Wang Kangfu Chen Understanding the heterogeneous immune repertoire of brain metastases for designing next‐gen therapeutics Brain-X brain tumor cell therapy immune profiling immunotherapy metastasis |
| title | Understanding the heterogeneous immune repertoire of brain metastases for designing next‐gen therapeutics |
| title_full | Understanding the heterogeneous immune repertoire of brain metastases for designing next‐gen therapeutics |
| title_fullStr | Understanding the heterogeneous immune repertoire of brain metastases for designing next‐gen therapeutics |
| title_full_unstemmed | Understanding the heterogeneous immune repertoire of brain metastases for designing next‐gen therapeutics |
| title_short | Understanding the heterogeneous immune repertoire of brain metastases for designing next‐gen therapeutics |
| title_sort | understanding the heterogeneous immune repertoire of brain metastases for designing next gen therapeutics |
| topic | brain tumor cell therapy immune profiling immunotherapy metastasis |
| url | https://doi.org/10.1002/brx2.33 |
| work_keys_str_mv | AT zongjiewang understandingtheheterogeneousimmunerepertoireofbrainmetastasesfordesigningnextgentherapeutics AT kangfuchen understandingtheheterogeneousimmunerepertoireofbrainmetastasesfordesigningnextgentherapeutics |