Foveal Phase Retardation Correlates With Optically Measured Henle Fiber Layer Thickness
This study quantified and compared phase retardation distribution in the central macula with the thickness of the Henle fiber layer (HFL). A scanning laser polarimeter (SLP) was used to acquire 20° × 40° macular-centered images, either with fixed corneal compensation or with variable corneal compens...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.846738/full |
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| author | Phillip T. Yuhas Marisa L. Ciamacca Keith A. Ramsey Danielle M. Mayne Elizabeth A. Stern-Green Matthew Ohr Aaron Zimmerman Andrew T. E. Hartwick Dean A. VanNasdale |
| author_facet | Phillip T. Yuhas Marisa L. Ciamacca Keith A. Ramsey Danielle M. Mayne Elizabeth A. Stern-Green Matthew Ohr Aaron Zimmerman Andrew T. E. Hartwick Dean A. VanNasdale |
| author_sort | Phillip T. Yuhas |
| collection | DOAJ |
| description | This study quantified and compared phase retardation distribution in the central macula with the thickness of the Henle fiber layer (HFL). A scanning laser polarimeter (SLP) was used to acquire 20° × 40° macular-centered images, either with fixed corneal compensation or with variable corneal compensation, in two cohorts of clinically normal subjects (N = 36). Phase retardation maps from SLP imaging were used to generate a macular cross pattern (fixed compensation) or an annulus pattern (variable compensation) centered on the macula. Intensity profiles in the phase retardation maps were produced using annular regions of interest at eccentricities from 0.25° to 3°. Pixel intensity was averaged at each eccentricity, acting as a surrogate for macular phase retardation. Directional OCT images were acquired in the horizontal and vertical meridians in all subjects, allowing visualization of the HFL thickness. HFL thickness was manually segmented in each meridian and averaged. In both cohorts, phase retardation and HFL thickness were highly correlated in the central 3° assessed, providing further evidence that the source of the phase retardation signal in the central macula is dominated by the HFL and that the center of the macula on cross sectional imaging corresponds closely with the center of the macular cross on SLP imaging. |
| first_indexed | 2024-04-14T00:31:59Z |
| format | Article |
| id | doaj.art-57d2c15009804421a9795a44b36cc5dd |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-14T00:31:59Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-57d2c15009804421a9795a44b36cc5dd2022-12-22T02:22:31ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-04-01910.3389/fmed.2022.846738846738Foveal Phase Retardation Correlates With Optically Measured Henle Fiber Layer ThicknessPhillip T. Yuhas0Marisa L. Ciamacca1Keith A. Ramsey2Danielle M. Mayne3Elizabeth A. Stern-Green4Matthew Ohr5Aaron Zimmerman6Andrew T. E. Hartwick7Dean A. VanNasdale8College of Optometry, The Ohio State University, Columbus, OH, United StatesCollege of Optometry, The Ohio State University, Columbus, OH, United StatesCollege of Optometry, The Ohio State University, Columbus, OH, United StatesCollege of Optometry, The Ohio State University, Columbus, OH, United StatesCollege of Optometry, The Ohio State University, Columbus, OH, United StatesDepartment of Ophthalmology and Visual Sciences, College of Medicine, The Ohio State University, Columbus, OH, United StatesCollege of Optometry, The Ohio State University, Columbus, OH, United StatesCollege of Optometry, The Ohio State University, Columbus, OH, United StatesCollege of Optometry, The Ohio State University, Columbus, OH, United StatesThis study quantified and compared phase retardation distribution in the central macula with the thickness of the Henle fiber layer (HFL). A scanning laser polarimeter (SLP) was used to acquire 20° × 40° macular-centered images, either with fixed corneal compensation or with variable corneal compensation, in two cohorts of clinically normal subjects (N = 36). Phase retardation maps from SLP imaging were used to generate a macular cross pattern (fixed compensation) or an annulus pattern (variable compensation) centered on the macula. Intensity profiles in the phase retardation maps were produced using annular regions of interest at eccentricities from 0.25° to 3°. Pixel intensity was averaged at each eccentricity, acting as a surrogate for macular phase retardation. Directional OCT images were acquired in the horizontal and vertical meridians in all subjects, allowing visualization of the HFL thickness. HFL thickness was manually segmented in each meridian and averaged. In both cohorts, phase retardation and HFL thickness were highly correlated in the central 3° assessed, providing further evidence that the source of the phase retardation signal in the central macula is dominated by the HFL and that the center of the macula on cross sectional imaging corresponds closely with the center of the macular cross on SLP imaging.https://www.frontiersin.org/articles/10.3389/fmed.2022.846738/fullHenle fiber layerscanning laser polarimetrydirectional optical coherence tomographyfoveamacula HFL thicknessphase retardation |
| spellingShingle | Phillip T. Yuhas Marisa L. Ciamacca Keith A. Ramsey Danielle M. Mayne Elizabeth A. Stern-Green Matthew Ohr Aaron Zimmerman Andrew T. E. Hartwick Dean A. VanNasdale Foveal Phase Retardation Correlates With Optically Measured Henle Fiber Layer Thickness Frontiers in Medicine Henle fiber layer scanning laser polarimetry directional optical coherence tomography fovea macula HFL thickness phase retardation |
| title | Foveal Phase Retardation Correlates With Optically Measured Henle Fiber Layer Thickness |
| title_full | Foveal Phase Retardation Correlates With Optically Measured Henle Fiber Layer Thickness |
| title_fullStr | Foveal Phase Retardation Correlates With Optically Measured Henle Fiber Layer Thickness |
| title_full_unstemmed | Foveal Phase Retardation Correlates With Optically Measured Henle Fiber Layer Thickness |
| title_short | Foveal Phase Retardation Correlates With Optically Measured Henle Fiber Layer Thickness |
| title_sort | foveal phase retardation correlates with optically measured henle fiber layer thickness |
| topic | Henle fiber layer scanning laser polarimetry directional optical coherence tomography fovea macula HFL thickness phase retardation |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.846738/full |
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