The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus
Diseases affecting the glomerulus, the filtration unit of the kidney, are a major cause of chronic kidney disease. Glomerular disease is characterised by injury of glomerular cells and is often accompanied by an inflammatory response that drives disease progression. New strategies are needed to slow...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/9/7684 |
| _version_ | 1797602515770933248 |
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| author | William J. Mason Elisavet Vasilopoulou |
| author_facet | William J. Mason Elisavet Vasilopoulou |
| author_sort | William J. Mason |
| collection | DOAJ |
| description | Diseases affecting the glomerulus, the filtration unit of the kidney, are a major cause of chronic kidney disease. Glomerular disease is characterised by injury of glomerular cells and is often accompanied by an inflammatory response that drives disease progression. New strategies are needed to slow the progression to end-stage kidney disease, which requires dialysis or transplantation. Thymosin β4 (Tβ4), an endogenous peptide that sequesters G-actin, has shown potent anti-inflammatory function in experimental models of heart, kidney, liver, lung, and eye injury. In this review, we discuss the role of endogenous and exogenous Tβ4 in glomerular disease progression and the current understanding of the underlying mechanisms. |
| first_indexed | 2024-03-11T04:18:04Z |
| format | Article |
| id | doaj.art-57d320d0827247a3bdaa34d318371f44 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:18:04Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-57d320d0827247a3bdaa34d318371f442023-11-17T22:59:09ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01249768410.3390/ijms24097684The Pathophysiological Role of Thymosin β4 in the Kidney GlomerulusWilliam J. Mason0Elisavet Vasilopoulou1Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UKComparative Biomedical Sciences, The Royal Veterinary College, London NW1 0TU, UKDiseases affecting the glomerulus, the filtration unit of the kidney, are a major cause of chronic kidney disease. Glomerular disease is characterised by injury of glomerular cells and is often accompanied by an inflammatory response that drives disease progression. New strategies are needed to slow the progression to end-stage kidney disease, which requires dialysis or transplantation. Thymosin β4 (Tβ4), an endogenous peptide that sequesters G-actin, has shown potent anti-inflammatory function in experimental models of heart, kidney, liver, lung, and eye injury. In this review, we discuss the role of endogenous and exogenous Tβ4 in glomerular disease progression and the current understanding of the underlying mechanisms.https://www.mdpi.com/1422-0067/24/9/7684thymosin β4glomeruluspodocytemacrophagechronic kidney disease |
| spellingShingle | William J. Mason Elisavet Vasilopoulou The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus International Journal of Molecular Sciences thymosin β4 glomerulus podocyte macrophage chronic kidney disease |
| title | The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus |
| title_full | The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus |
| title_fullStr | The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus |
| title_full_unstemmed | The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus |
| title_short | The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus |
| title_sort | pathophysiological role of thymosin β4 in the kidney glomerulus |
| topic | thymosin β4 glomerulus podocyte macrophage chronic kidney disease |
| url | https://www.mdpi.com/1422-0067/24/9/7684 |
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