Transparent Cross-Flow Platform as Chemiluminescence Detection Cell in Cross Injection Analysis
This work presents the use of a transparent ‘Cross Injection Analysis’ (CIA) platform as a flow system for chemiluminescence (CL) measurements. The CL-CIA flow device incorporates introduction channels for samples and reagents, and the reaction and detection channels are in one acrylic unit. A photo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/3/1316 |
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| author | Thachkorn Somboonsuk Phoonthawee Saetear Thitirat Mantim Nuanlaor Ratanawimarnwong Prapin Wilairat Nathawut Choengchan Duangjai Nacapricha |
| author_facet | Thachkorn Somboonsuk Phoonthawee Saetear Thitirat Mantim Nuanlaor Ratanawimarnwong Prapin Wilairat Nathawut Choengchan Duangjai Nacapricha |
| author_sort | Thachkorn Somboonsuk |
| collection | DOAJ |
| description | This work presents the use of a transparent ‘Cross Injection Analysis’ (CIA) platform as a flow system for chemiluminescence (CL) measurements. The CL-CIA flow device incorporates introduction channels for samples and reagents, and the reaction and detection channels are in one acrylic unit. A photomultiplier tube placed above the reaction channel detects the emitted luminescence. The system was applied to the analysis of (i) Co(II) via the Co(II)-catalyzed H<sub>2</sub>O<sub>2</sub>-luminol reaction and (ii) paracetamol via its inhibitory effect on the catalytic activity of Fe(CN)<sub>6</sub><sup>3−</sup> on the H<sub>2</sub>O<sub>2</sub>-luminol reaction. A linear calibration was obtained for Co(II) in the range of 0.002 to 0.025 mg L<sup>−1</sup> Co(II) (r<sup>2</sup> = 0.9977) for the determination of Co(II) in water samples. The linear calibration obtained for the paracetamol was 10 to 200 mg L<sup>−1</sup> (r<sup>2</sup> = 0.9906) for the determination of pharmaceutical products. The sample throughput was 60 samples h<sup>−1</sup>. The precision was ≤4.2% RSD. The consumption of the samples and reagents was ca. 170 µL per analysis cycle. |
| first_indexed | 2024-03-11T09:32:19Z |
| format | Article |
| id | doaj.art-57d4aec1506642e3b211bf3a833ef68c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T09:32:19Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-57d4aec1506642e3b211bf3a833ef68c2023-11-16T17:30:44ZengMDPI AGMolecules1420-30492023-01-01283131610.3390/molecules28031316Transparent Cross-Flow Platform as Chemiluminescence Detection Cell in Cross Injection AnalysisThachkorn Somboonsuk0Phoonthawee Saetear1Thitirat Mantim2Nuanlaor Ratanawimarnwong3Prapin Wilairat4Nathawut Choengchan5Duangjai Nacapricha6Flow Innovation-Research for Science and Technology Laboratories (Firstlabs), Ratchathewi District, Bangkok 10110, ThailandFlow Innovation-Research for Science and Technology Laboratories (Firstlabs), Ratchathewi District, Bangkok 10110, ThailandFlow Innovation-Research for Science and Technology Laboratories (Firstlabs), Ratchathewi District, Bangkok 10110, ThailandFlow Innovation-Research for Science and Technology Laboratories (Firstlabs), Ratchathewi District, Bangkok 10110, ThailandFlow Innovation-Research for Science and Technology Laboratories (Firstlabs), Ratchathewi District, Bangkok 10110, ThailandFlow Innovation-Research for Science and Technology Laboratories (Firstlabs), Ratchathewi District, Bangkok 10110, ThailandFlow Innovation-Research for Science and Technology Laboratories (Firstlabs), Ratchathewi District, Bangkok 10110, ThailandThis work presents the use of a transparent ‘Cross Injection Analysis’ (CIA) platform as a flow system for chemiluminescence (CL) measurements. The CL-CIA flow device incorporates introduction channels for samples and reagents, and the reaction and detection channels are in one acrylic unit. A photomultiplier tube placed above the reaction channel detects the emitted luminescence. The system was applied to the analysis of (i) Co(II) via the Co(II)-catalyzed H<sub>2</sub>O<sub>2</sub>-luminol reaction and (ii) paracetamol via its inhibitory effect on the catalytic activity of Fe(CN)<sub>6</sub><sup>3−</sup> on the H<sub>2</sub>O<sub>2</sub>-luminol reaction. A linear calibration was obtained for Co(II) in the range of 0.002 to 0.025 mg L<sup>−1</sup> Co(II) (r<sup>2</sup> = 0.9977) for the determination of Co(II) in water samples. The linear calibration obtained for the paracetamol was 10 to 200 mg L<sup>−1</sup> (r<sup>2</sup> = 0.9906) for the determination of pharmaceutical products. The sample throughput was 60 samples h<sup>−1</sup>. The precision was ≤4.2% RSD. The consumption of the samples and reagents was ca. 170 µL per analysis cycle.https://www.mdpi.com/1420-3049/28/3/1316cross injection analysischemiluminescencecross-flowcobaltparacetamol |
| spellingShingle | Thachkorn Somboonsuk Phoonthawee Saetear Thitirat Mantim Nuanlaor Ratanawimarnwong Prapin Wilairat Nathawut Choengchan Duangjai Nacapricha Transparent Cross-Flow Platform as Chemiluminescence Detection Cell in Cross Injection Analysis Molecules cross injection analysis chemiluminescence cross-flow cobalt paracetamol |
| title | Transparent Cross-Flow Platform as Chemiluminescence Detection Cell in Cross Injection Analysis |
| title_full | Transparent Cross-Flow Platform as Chemiluminescence Detection Cell in Cross Injection Analysis |
| title_fullStr | Transparent Cross-Flow Platform as Chemiluminescence Detection Cell in Cross Injection Analysis |
| title_full_unstemmed | Transparent Cross-Flow Platform as Chemiluminescence Detection Cell in Cross Injection Analysis |
| title_short | Transparent Cross-Flow Platform as Chemiluminescence Detection Cell in Cross Injection Analysis |
| title_sort | transparent cross flow platform as chemiluminescence detection cell in cross injection analysis |
| topic | cross injection analysis chemiluminescence cross-flow cobalt paracetamol |
| url | https://www.mdpi.com/1420-3049/28/3/1316 |
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