Tea Polyphenols Prevent and Intervene in COVID-19 through Intestinal Microbiota
Although all countries have taken corresponding measures, the coronavirus disease 2019 (COVID-19) is still ravaging the world. To consolidate the existing anti-epidemic results and further strengthen the prevention and control measures against the new coronavirus, we are now actively pioneering a no...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/11/4/506 |
| _version_ | 1797480355195781120 |
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| author | Qiao Xiang Lu Cheng Ruilin Zhang Yanan Liu Zufang Wu Xin Zhang |
| author_facet | Qiao Xiang Lu Cheng Ruilin Zhang Yanan Liu Zufang Wu Xin Zhang |
| author_sort | Qiao Xiang |
| collection | DOAJ |
| description | Although all countries have taken corresponding measures, the coronavirus disease 2019 (COVID-19) is still ravaging the world. To consolidate the existing anti-epidemic results and further strengthen the prevention and control measures against the new coronavirus, we are now actively pioneering a novel research idea of regulating the intestinal microbiota through tea polyphenols for reference. Although studies have long revealed the regulatory effect of tea polyphenols on the intestinal microbiota to various gastrointestinal inflammations, little is known about the prevention and intervention of COVID-19. This review summarizes the possible mechanism of the influence of tea polyphenols on COVID-19 mediated by the intestinal microbiota. In this review, the latest studies of tea polyphenols exhibiting their own antibacterial and anti-inflammatory activities and protective effects on the intestinal mucosal barrier are combed through and summarized. Among them, (−)-epigallocatechin-3-gallate (EGCG), one of the main monomers of catechins, may be activated as nuclear factor erythroid 2 p45-related factor 2 (Nrf2). The agent inhibits the expression of ACE2 (a cellular receptor for SARS-CoV-2) and TMPRSS2 to inhibit SARS-CoV-2 infection, inhibiting the life cycle of SARS-CoV-2. Thus, preliminary reasoning and judgments have been made about the possible mechanism of the effect of tea polyphenols on the COVID-19 control and prevention mediated by the microbiota. These results may be of great significance to the future exploration of specialized research in this field. |
| first_indexed | 2024-03-09T21:58:33Z |
| format | Article |
| id | doaj.art-57d4cd9682e84cd3947fcc3ab4ad037c |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-09T21:58:33Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-57d4cd9682e84cd3947fcc3ab4ad037c2023-11-23T19:52:57ZengMDPI AGFoods2304-81582022-02-0111450610.3390/foods11040506Tea Polyphenols Prevent and Intervene in COVID-19 through Intestinal MicrobiotaQiao Xiang0Lu Cheng1Ruilin Zhang2Yanan Liu3Zufang Wu4Xin Zhang5Department of Food Science and Engineering, Ningbo University, Ningbo 315211, ChinaDepartment of Food Science, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USAKey Laboratory of Animal Protein Deep Processing Technology of Zhejiang Province, Ningbo University, Ningbo 315211, ChinaDepartment of Food Science and Engineering, Ningbo University, Ningbo 315211, ChinaDepartment of Food Science and Engineering, Ningbo University, Ningbo 315211, ChinaDepartment of Food Science and Engineering, Ningbo University, Ningbo 315211, ChinaAlthough all countries have taken corresponding measures, the coronavirus disease 2019 (COVID-19) is still ravaging the world. To consolidate the existing anti-epidemic results and further strengthen the prevention and control measures against the new coronavirus, we are now actively pioneering a novel research idea of regulating the intestinal microbiota through tea polyphenols for reference. Although studies have long revealed the regulatory effect of tea polyphenols on the intestinal microbiota to various gastrointestinal inflammations, little is known about the prevention and intervention of COVID-19. This review summarizes the possible mechanism of the influence of tea polyphenols on COVID-19 mediated by the intestinal microbiota. In this review, the latest studies of tea polyphenols exhibiting their own antibacterial and anti-inflammatory activities and protective effects on the intestinal mucosal barrier are combed through and summarized. Among them, (−)-epigallocatechin-3-gallate (EGCG), one of the main monomers of catechins, may be activated as nuclear factor erythroid 2 p45-related factor 2 (Nrf2). The agent inhibits the expression of ACE2 (a cellular receptor for SARS-CoV-2) and TMPRSS2 to inhibit SARS-CoV-2 infection, inhibiting the life cycle of SARS-CoV-2. Thus, preliminary reasoning and judgments have been made about the possible mechanism of the effect of tea polyphenols on the COVID-19 control and prevention mediated by the microbiota. These results may be of great significance to the future exploration of specialized research in this field.https://www.mdpi.com/2304-8158/11/4/506COVID-19intestinal microecologytea polyphenolsmicrobiota |
| spellingShingle | Qiao Xiang Lu Cheng Ruilin Zhang Yanan Liu Zufang Wu Xin Zhang Tea Polyphenols Prevent and Intervene in COVID-19 through Intestinal Microbiota Foods COVID-19 intestinal microecology tea polyphenols microbiota |
| title | Tea Polyphenols Prevent and Intervene in COVID-19 through Intestinal Microbiota |
| title_full | Tea Polyphenols Prevent and Intervene in COVID-19 through Intestinal Microbiota |
| title_fullStr | Tea Polyphenols Prevent and Intervene in COVID-19 through Intestinal Microbiota |
| title_full_unstemmed | Tea Polyphenols Prevent and Intervene in COVID-19 through Intestinal Microbiota |
| title_short | Tea Polyphenols Prevent and Intervene in COVID-19 through Intestinal Microbiota |
| title_sort | tea polyphenols prevent and intervene in covid 19 through intestinal microbiota |
| topic | COVID-19 intestinal microecology tea polyphenols microbiota |
| url | https://www.mdpi.com/2304-8158/11/4/506 |
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