Lysophosphatidic Acid Receptor Antagonists and Cancer: The Current Trends, Clinical Implications, and Trials

Lysophosphatidic Acid Receptor Antagonists and Cancer: The Current Trends, Clinical Implications, and Trials

Lysophosphatidic acid (LPA) is a bioactive lipid mediator primarily derived from membrane phospholipids. LPA initiates cellular effects upon binding to a family of G protein-coupled receptors, termed LPA receptors (LPAR1 to LPAR6). LPA signaling drives cell migration and proliferation, cytokine prod...

Full description

Bibliographic Details
Main Authors:	Yu-Hsuan Lin, Yueh-Chien Lin, Chien-Chin Chen
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Series:	Cells
Subjects:	antagonist cancer clinical trial lysophosphatidic acid lysophosphatidic receptor therapy
Online Access:	https://www.mdpi.com/2073-4409/10/7/1629

Similar Items

In vitro pharmacological characterization of standard and new lysophosphatidic acid receptor antagonists using dynamic mass redistribution assay
by: C. Ruzza, et al.
Published: (2023-11-01)

Emerging Roles of Lysophosphatidic Acid in Macrophages and Inflammatory Diseases
by: Shufan Jiang, et al.
Published: (2023-08-01)

Lysophosphatidic Acid Receptor 3 Activation Is Involved in the Regulation of Ferroptosis
by: Yi-Xun Huang, et al.
Published: (2024-02-01)

Entering, Linked with the Sphinx: Lysophosphatidic Acids Everywhere, All at Once, in the Oral System and Cancer
by: D. Roselyn Cerutis, et al.
Published: (2023-06-01)

Lysophosphatidic acid and itsreceptors: Role in bronchial asthma pathogenesis
by: O. Yu. Kytikova, et al.
Published: (2024-03-01)

KA-1002, a Novel Lysophosphatidic Acid Signaling Antagonist, Alleviates Bovine Tracheal Cell Disruption and Inflammation
by: Hee-su Shin, et al.
Published: (2020-02-01)

Lysophosphatidic Acid Signaling and microRNAs: New Roles in Various Cancers
by: Mahdi Rafiyan, et al.
Published: (2022-06-01)

Dual Role of Lysophosphatidic Acid Receptor 2 (LPA2) in Amyotrophic Lateral Sclerosis
by: Maria Puigdomenech-Poch, et al.
Published: (2021-03-01)

Elevated plasma levels of lysophosphatidic acid and aberrant expression of lysophosphatidic acid receptors in adenomyosis
by: Bicheng Yang, et al.
Published: (2017-11-01)

Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors
by: Eunah Shin, et al.
Published: (2019-08-01)

Lysophosphatidic acid supports the development of vitrified ovarian follicles by decreasing the incidence of cell death: An experimental study
by: Neda Abedpour, et al.
Published: (2022-04-01)

Supplementation of Culture Media with Lysophosphatidic Acid Improves The Follicular Development of Human Ovarian Tissue after Xenotransplantaion into The Back Muscle of γ-Irradiated Mice
by: Zeynab Mohammadi, et al.
Published: (2020-10-01)

Phosphatidic Acid Stimulates Myoblast Proliferation through Interaction with LPA1 and LPA2 Receptors
by: Ana Gomez-Larrauri, et al.
Published: (2021-02-01)

A Novel Therapeutic Reagent, KA-1002 for Alleviating Lysophosphatidic Acid-Mediated Inflammation Related Gene Expression in Swine Macrophages
by: Hyeon-Jeong Hwang, et al.
Published: (2020-03-01)

Lysophosphatidic Acid Signaling in Cancer Cells: What Makes LPA So Special?
by: Pravita Balijepalli, et al.
Published: (2021-08-01)

Regulation of Tumor Immunity by Lysophosphatidic Acid
by: Sue Chin Lee, et al.
Published: (2020-05-01)

Lysophosphatidic Acid and Autotaxin-associated Effects on the Initiation and Progression of Colorectal Cancer
by: C. Chris Yun
Published: (2019-07-01)

Lysophosphatidic Acid Receptor 3 Suppress Neutrophil Extracellular Traps Production and Thrombosis During Sepsis
by: Shengqiang Pei, et al.
Published: (2022-04-01)

Lysophosphatidic Acid Receptor 1- and 3-Mediated Hyperalgesia and Hypoalgesia in Diabetic Neuropathic Pain Models in Mice
by: Hiroshi Ueda, et al.
Published: (2020-08-01)

Suppressing postcollection lysophosphatidic acid metabolism improves the precision of plasma LPA quantification
by: Kuniyuki Kano, et al.
Published: (2021-01-01)

The LPA<sub>3</sub> Receptor: Regulation and Activation of Signaling Pathways
by: Karina Helivier Solís, et al.
Published: (2021-06-01)

Profiling lysophosphatidic acid levels in plasma from head and neck cancer patients
by: Mariati Abdul Rahman, et al.
Published: (2020-06-01)

Discoidin Domain Receptor 2 Mediates Lysophosphatidic Acid-Induced Ovarian Cancer Aggressiveness
by: Bo Young Jeong, et al.
Published: (2021-05-01)

Effects of autotaxin and lysophosphatidic acid deficiencies on depression-like behaviors in mice exposed to chronic unpredictable mild stress
by: Chao Wang, et al.
Published: (2024-05-01)

Autotaxin/Lysophosphatidic Acid Axis: From Bone Biology to Bone Disorders
by: Candide Alioli, et al.
Published: (2022-03-01)

Lysophosphatidic Acid Is a Proinflammatory Stimulus of Renal Tubular Epithelial Cells
by: Christiana Magkrioti, et al.
Published: (2022-07-01)

Role of Aberrantly Activated Lysophosphatidic Acid Receptor 1 Signaling Mediated Inflammation in Renal Aging
by: Yongjie Jin, et al.
Published: (2021-09-01)

Roles of Autotaxin/Autotaxin-Lysophosphatidic Acid Axis in the Initiation and Progression of Liver Cancer
by: Sha She, et al.
Published: (2022-06-01)

Inhibition of lysophosphatidic acid receptor 1–3 deteriorates experimental autoimmune encephalomyelitis by inducing oxidative stress
by: Jong Hee Choi, et al.
Published: (2021-10-01)

Lysophosphatidic acid (LPA) 18:1 transcriptional regulation of primary human gingival fibroblasts
by: D. Roselyn Cerutis, et al.
Published: (2014-12-01)

TAZ Mediates Lysophosphatidic Acid-Induced Migration and Proliferation of Epithelial Ovarian Cancer Cells
by: Geun Ok Jeong, et al.
Published: (2013-07-01)

Lysophosphatidic acid stimulates rat uterine contraction in vitro
by: Satoshi NAGASHIMA, et al.
Published: (2023-04-01)

Detection of the Ovarian Cancer Biomarker Lysophosphatidic Acid in Serum
by: Brian De La Franier, et al.
Published: (2020-02-01)

Polydopamine-Lysophosphatidate-Functionalised Titanium: A Novel Hybrid Surface Finish for Bone Regenerative Applications
by: Fiona Baldwin, et al.
Published: (2020-03-01)

Lysophosphatidic Acid Promotes Epithelial to Mesenchymal Transition in Ovarian Cancer Cells by Repressing SIRT1
by: Upasana Ray, et al.
Published: (2017-02-01)

Lysophosphatidic Acid Inhibits Simvastatin-Induced Myocytoxicity by Activating LPA Receptor/PKC Pathway
by: Kyung-Jong Won, et al.
Published: (2020-03-01)

Lysophosphatidic Acid Receptor 1 Specifically Labels Seizure-Induced Hippocampal Reactive Neural Stem Cells and Regulates Their Division
by: Roberto Valcárcel-Martín, et al.
Published: (2020-08-01)

ADSCs and adipocytes are the main producers in the autotaxin–lysophosphatidic acid axis of breast cancer and healthy mammary tissue in vitro
by: Rafael Schmid, et al.
Published: (2018-12-01)

A Novel Function of the Lysophosphatidic Acid Receptor 3 (LPAR3) Gene in Zebrafish on Modulating Anxiety, Circadian Rhythm Locomotor Activity, and Short-Term Memory
by: Yu-Nung Lin, et al.
Published: (2020-04-01)

Lysophosphatidic Acid Receptor 5 Contributes to Imiquimod-Induced Psoriasis-Like Lesions through NLRP3 Inflammasome Activation in Macrophages
by: Bhakta Prasad Gaire, et al.
Published: (2020-07-01)