Identification of the transgenic integration site in immunodeficient tgε26 human CD3ε transgenic mice.

Identification of the transgenic integration site in immunodeficient tgε26 human CD3ε transgenic mice.

A strain of human CD3ε transgenic mice, tgε26, exhibits severe immunodeficiency associated with early arrest of T cell development. Complete loss of T cells is observed in homozygous tgε26 mice, but not in heterozygotes, suggesting that genomic disruption due to transgenic integration may contribute...

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Bibliographic Details
Main Authors: Izumi Ohigashi, Yuki Yamasaki, Tsukasa Hirashima, Yousuke Takahama
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3008721?pdf=render

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