Visceral leishmaniasis and HIV coinfection in the Mediterranean region.
Visceral leishmaniasis is hypoendemic in Mediterranean countries, where it is caused by the flagellate protozoan Leishmania infantum. VL cases in this area account for 5%-6% of the global burden. Cases of Leishmania/HIV coinfection have been reported in the Mediterranean region, mainly in France, It...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-08-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC4140663?pdf=render |
| _version_ | 1811276331290198016 |
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| author | Begoña Monge-Maillo Francesca F Norman Israel Cruz Jorge Alvar Rogelio López-Vélez |
| author_facet | Begoña Monge-Maillo Francesca F Norman Israel Cruz Jorge Alvar Rogelio López-Vélez |
| author_sort | Begoña Monge-Maillo |
| collection | DOAJ |
| description | Visceral leishmaniasis is hypoendemic in Mediterranean countries, where it is caused by the flagellate protozoan Leishmania infantum. VL cases in this area account for 5%-6% of the global burden. Cases of Leishmania/HIV coinfection have been reported in the Mediterranean region, mainly in France, Italy, Portugal, and Spain. Since highly active antiretroviral therapy was introduced in 1997, a marked decrease in the number of coinfected cases in this region has been reported. The development of new diagnostic methods to accurately identify level of parasitemia and the risk of relapse is one of the main challenges in improving the treatment of coinfected patients. Clinical trials in the Mediterranean region are needed to determine the most adequate therapeutic options for Leishmania/HIV patients as well as the indications and regimes for secondary prophylaxis. This article reviews the epidemiological, diagnostic, clinical, and therapeutic aspects of Leishmania/HIV coinfection in the Mediterranean region. |
| first_indexed | 2024-04-12T23:54:44Z |
| format | Article |
| id | doaj.art-57d71aace168471ab562952fa1f98e91 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-12T23:54:44Z |
| publishDate | 2014-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-57d71aace168471ab562952fa1f98e912022-12-22T03:11:33ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352014-08-0188e302110.1371/journal.pntd.0003021Visceral leishmaniasis and HIV coinfection in the Mediterranean region.Begoña Monge-MailloFrancesca F NormanIsrael CruzJorge AlvarRogelio López-VélezVisceral leishmaniasis is hypoendemic in Mediterranean countries, where it is caused by the flagellate protozoan Leishmania infantum. VL cases in this area account for 5%-6% of the global burden. Cases of Leishmania/HIV coinfection have been reported in the Mediterranean region, mainly in France, Italy, Portugal, and Spain. Since highly active antiretroviral therapy was introduced in 1997, a marked decrease in the number of coinfected cases in this region has been reported. The development of new diagnostic methods to accurately identify level of parasitemia and the risk of relapse is one of the main challenges in improving the treatment of coinfected patients. Clinical trials in the Mediterranean region are needed to determine the most adequate therapeutic options for Leishmania/HIV patients as well as the indications and regimes for secondary prophylaxis. This article reviews the epidemiological, diagnostic, clinical, and therapeutic aspects of Leishmania/HIV coinfection in the Mediterranean region.http://europepmc.org/articles/PMC4140663?pdf=render |
| spellingShingle | Begoña Monge-Maillo Francesca F Norman Israel Cruz Jorge Alvar Rogelio López-Vélez Visceral leishmaniasis and HIV coinfection in the Mediterranean region. PLoS Neglected Tropical Diseases |
| title | Visceral leishmaniasis and HIV coinfection in the Mediterranean region. |
| title_full | Visceral leishmaniasis and HIV coinfection in the Mediterranean region. |
| title_fullStr | Visceral leishmaniasis and HIV coinfection in the Mediterranean region. |
| title_full_unstemmed | Visceral leishmaniasis and HIV coinfection in the Mediterranean region. |
| title_short | Visceral leishmaniasis and HIV coinfection in the Mediterranean region. |
| title_sort | visceral leishmaniasis and hiv coinfection in the mediterranean region |
| url | http://europepmc.org/articles/PMC4140663?pdf=render |
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