Evaluation of antiarthritic activity of ethanolic extract of Derris brevipes (benth.) Baker leaves
Background: Derris brevipes is a common medicinal plant used in the traditional system of medicine as an anti-arthritic agent. Aims and Objectives: The present study was to evaluate the anti-arthritic activity of ethanolic extract of D. brevipes (EEDB) leaves, belonging to the family Leguminosae....
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2023-09-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/55112 |
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| author | Nesni M Makkar Veena R Priya Mohan B.N Jeena Ann John Princy Louis Palatty Sanitha Kuriachan |
| author_facet | Nesni M Makkar Veena R Priya Mohan B.N Jeena Ann John Princy Louis Palatty Sanitha Kuriachan |
| author_sort | Nesni M Makkar |
| collection | DOAJ |
| description | Background: Derris brevipes is a common medicinal plant used in the traditional system of medicine as an anti-arthritic agent.
Aims and Objectives: The present study was to evaluate the anti-arthritic activity of ethanolic extract of D. brevipes (EEDB) leaves, belonging to the family Leguminosae.
Materials and Methods: The dried leaves were collected and extracted using 95% ethanol, and the extract was subjected to a preliminary phytochemical screening. In vivo activities were evaluated in collagen (chicken sternal collagen)-induced arthritis (CIA) in Sprague–Dawley rats. Prednisolone was used as the standard, and EEDB (at doses of 300 mg/kg and 600 mg/kg) was administered through the oral route. Body weight measurement, arthritic score, histological score, and radiology score assessments were carried out.
Results: Preliminary phytochemical screening of leaf extract from D. brevipes showed the presence of components such as steroids, triterpenoids, and flavonoids. In vivo tests on CIA rats given the extract showed that it could lower the arthritic score, the paw volume, the radiological score, and the histological score.
Conclusion: From this study, it is concluded that the D. brevipes leaf extract possesses antiarthritic activity. |
| first_indexed | 2024-03-12T11:04:21Z |
| format | Article |
| id | doaj.art-57d88a2c839546aba17a4a347cd1e098 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-03-12T11:04:21Z |
| publishDate | 2023-09-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-57d88a2c839546aba17a4a347cd1e0982023-09-02T04:11:37ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-09-011498390https://doi.org/10.3126/ajms.v14i9.55112Evaluation of antiarthritic activity of ethanolic extract of Derris brevipes (benth.) Baker leavesNesni M Makkar 0https://orcid.org/0000-0001-6043-1812Veena R 1https://orcid.org/0009-0002-7895-0308Priya Mohan B.N 2https://orcid.org/0000-0001-7796-1190Jeena Ann John 3https://orcid.org/0000-0002-5377-8727Princy Louis Palatty 4https://orcid.org/0000-0003-4147-0482Sanitha Kuriachan 5https://orcid.org/0000-0002-2711-9816Associate Professor, Department of Pharmacology, Al-Azhar College of Pharmacy, Thodupuzha, Kerala, India Professor, Department of Pharmaceutical Sciences, Center for Professional and Advanced Studies, Kottayam, Kerala, India Associate Professor, Department of Pharmacology, DM WIMS Medical College, Wayanad, Kerala, India Assistant Professor, Department of Pharmacology, Al-Azhar College of Pharmacy, Thodupuzha, Kerala, India Professor, Department of Pharmacology, Amrita School of Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kerala, India Associate Professor, Department of Pharmacology, Amrita School of Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kerala, India Background: Derris brevipes is a common medicinal plant used in the traditional system of medicine as an anti-arthritic agent. Aims and Objectives: The present study was to evaluate the anti-arthritic activity of ethanolic extract of D. brevipes (EEDB) leaves, belonging to the family Leguminosae. Materials and Methods: The dried leaves were collected and extracted using 95% ethanol, and the extract was subjected to a preliminary phytochemical screening. In vivo activities were evaluated in collagen (chicken sternal collagen)-induced arthritis (CIA) in Sprague–Dawley rats. Prednisolone was used as the standard, and EEDB (at doses of 300 mg/kg and 600 mg/kg) was administered through the oral route. Body weight measurement, arthritic score, histological score, and radiology score assessments were carried out. Results: Preliminary phytochemical screening of leaf extract from D. brevipes showed the presence of components such as steroids, triterpenoids, and flavonoids. In vivo tests on CIA rats given the extract showed that it could lower the arthritic score, the paw volume, the radiological score, and the histological score. Conclusion: From this study, it is concluded that the D. brevipes leaf extract possesses antiarthritic activity.https://www.nepjol.info/index.php/AJMS/article/view/55112musculoskeletal and joint diseases; arthritis; rheumatoid arthritis; collagen induced arthritis |
| spellingShingle | Nesni M Makkar Veena R Priya Mohan B.N Jeena Ann John Princy Louis Palatty Sanitha Kuriachan Evaluation of antiarthritic activity of ethanolic extract of Derris brevipes (benth.) Baker leaves Asian Journal of Medical Sciences musculoskeletal and joint diseases; arthritis; rheumatoid arthritis; collagen induced arthritis |
| title | Evaluation of antiarthritic activity of ethanolic extract of Derris brevipes (benth.) Baker leaves |
| title_full | Evaluation of antiarthritic activity of ethanolic extract of Derris brevipes (benth.) Baker leaves |
| title_fullStr | Evaluation of antiarthritic activity of ethanolic extract of Derris brevipes (benth.) Baker leaves |
| title_full_unstemmed | Evaluation of antiarthritic activity of ethanolic extract of Derris brevipes (benth.) Baker leaves |
| title_short | Evaluation of antiarthritic activity of ethanolic extract of Derris brevipes (benth.) Baker leaves |
| title_sort | evaluation of antiarthritic activity of ethanolic extract of derris brevipes benth baker leaves |
| topic | musculoskeletal and joint diseases; arthritis; rheumatoid arthritis; collagen induced arthritis |
| url | https://www.nepjol.info/index.php/AJMS/article/view/55112 |
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