Titrimetric and spectrophotometric assay of felodipine in tablets using bromate–bromide, Methyl Orange and Indigo Carmine reagents
Three new methods based on titrimetric and spectrophotometric techniques are described for the determination of felodipine (FLD) in the bulk drug and in tablets using a bromate–bromide mixture and two dyes, Methyl Orange and Indigo Carmine. In the titrimetric method (method A), the drug solution was...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2005-01-01
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| Series: | Journal of the Serbian Chemical Society |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2005/0352-51390507969B.pdf |
| _version_ | 1819280608539443200 |
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| author | Basavaiah Kanakapura Chandrashekar Umakanthappa Gowda Nage Paregowda |
| author_facet | Basavaiah Kanakapura Chandrashekar Umakanthappa Gowda Nage Paregowda |
| author_sort | Basavaiah Kanakapura |
| collection | DOAJ |
| description | Three new methods based on titrimetric and spectrophotometric techniques are described for the determination of felodipine (FLD) in the bulk drug and in tablets using a bromate–bromide mixture and two dyes, Methyl Orange and Indigo Carmine. In the titrimetric method (method A), the drug solution was treated with a measured excess of the bromate–bromide mixture in acid medium and after the reaction was judged to be complete, the unreacted bromine was determined iodometrically. The two spectrophotometric methods are based on the bromination of the drug with a known excess of the bromate–bromide mixture under acidic conditions followed by the estimation of the surplus bromine by reaction with either Methyl Orange (Method B) or Indigo Carmine (Method C) and measuring the absorbance at 520 nm or 610 nm, respectively. In all the methods, the amount of reacted bromine corresponds to the drug content. The titrimetric procedure is applicable for between 6–15 mg and the reaction stoichiometry was found to be 1:1 (drug: BrO3–). The systems obey Beer’s law between 0.12 – 0.87 μgml-1 and 0.5 – 6.0 μgml-1 formethods B and C respectively. The limits of detection and quantification are reported for both the spectrophotometric methods. The methods could usefully be applied to routine quality control of pharmaceutical formulations containing FLD. Statistical comparison of the results with the reference method shows excellent agreement and indicates no significant difference in accuracy and precision. |
| first_indexed | 2024-12-24T00:46:30Z |
| format | Article |
| id | doaj.art-57d8b2d0a5e7470cb0a9e4f6ad9b9497 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-12-24T00:46:30Z |
| publishDate | 2005-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-57d8b2d0a5e7470cb0a9e4f6ad9b94972022-12-21T17:23:47ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212005-01-0170796997810.2298/JSC0507969B0352-51390507969BTitrimetric and spectrophotometric assay of felodipine in tablets using bromate–bromide, Methyl Orange and Indigo Carmine reagentsBasavaiah Kanakapura0Chandrashekar Umakanthappa1Gowda Nage Paregowda2Deparment of Chemistry, University of Mysore, Manasagangotri, IndiaDeparment of Chemistry, University of Mysore, Manasagangotri, IndiaDeparment of Chemistry, University of Mysore, Manasagangotri, IndiaThree new methods based on titrimetric and spectrophotometric techniques are described for the determination of felodipine (FLD) in the bulk drug and in tablets using a bromate–bromide mixture and two dyes, Methyl Orange and Indigo Carmine. In the titrimetric method (method A), the drug solution was treated with a measured excess of the bromate–bromide mixture in acid medium and after the reaction was judged to be complete, the unreacted bromine was determined iodometrically. The two spectrophotometric methods are based on the bromination of the drug with a known excess of the bromate–bromide mixture under acidic conditions followed by the estimation of the surplus bromine by reaction with either Methyl Orange (Method B) or Indigo Carmine (Method C) and measuring the absorbance at 520 nm or 610 nm, respectively. In all the methods, the amount of reacted bromine corresponds to the drug content. The titrimetric procedure is applicable for between 6–15 mg and the reaction stoichiometry was found to be 1:1 (drug: BrO3–). The systems obey Beer’s law between 0.12 – 0.87 μgml-1 and 0.5 – 6.0 μgml-1 formethods B and C respectively. The limits of detection and quantification are reported for both the spectrophotometric methods. The methods could usefully be applied to routine quality control of pharmaceutical formulations containing FLD. Statistical comparison of the results with the reference method shows excellent agreement and indicates no significant difference in accuracy and precision.http://www.doiserbia.nb.rs/img/doi/0352-5139/2005/0352-51390507969B.pdffelodipinebromate–bromidedeterminationmethyl orangeindigo carmineformulations |
| spellingShingle | Basavaiah Kanakapura Chandrashekar Umakanthappa Gowda Nage Paregowda Titrimetric and spectrophotometric assay of felodipine in tablets using bromate–bromide, Methyl Orange and Indigo Carmine reagents Journal of the Serbian Chemical Society felodipine bromate–bromide determination methyl orange indigo carmine formulations |
| title | Titrimetric and spectrophotometric assay of felodipine in tablets using bromate–bromide, Methyl Orange and Indigo Carmine reagents |
| title_full | Titrimetric and spectrophotometric assay of felodipine in tablets using bromate–bromide, Methyl Orange and Indigo Carmine reagents |
| title_fullStr | Titrimetric and spectrophotometric assay of felodipine in tablets using bromate–bromide, Methyl Orange and Indigo Carmine reagents |
| title_full_unstemmed | Titrimetric and spectrophotometric assay of felodipine in tablets using bromate–bromide, Methyl Orange and Indigo Carmine reagents |
| title_short | Titrimetric and spectrophotometric assay of felodipine in tablets using bromate–bromide, Methyl Orange and Indigo Carmine reagents |
| title_sort | titrimetric and spectrophotometric assay of felodipine in tablets using bromate bromide methyl orange and indigo carmine reagents |
| topic | felodipine bromate–bromide determination methyl orange indigo carmine formulations |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2005/0352-51390507969B.pdf |
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