Systems Biology Understanding of the Effects of Lithium on Affective and Neurodegenerative Disorders
Lithium has many widely varying biochemical and phenomenological effects, suggesting that a systems biology approach is required to understand its action. Multiple lines of evidence point to lithium intake and consequent blood levels as important determinants of incidence of neurodegenerative diseas...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-12-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2018.00933/full |
| _version_ | 1818066489572327424 |
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| author | Weihao Ge Weihao Ge Eric Jakobsson Eric Jakobsson Eric Jakobsson |
| author_facet | Weihao Ge Weihao Ge Eric Jakobsson Eric Jakobsson Eric Jakobsson |
| author_sort | Weihao Ge |
| collection | DOAJ |
| description | Lithium has many widely varying biochemical and phenomenological effects, suggesting that a systems biology approach is required to understand its action. Multiple lines of evidence point to lithium intake and consequent blood levels as important determinants of incidence of neurodegenerative disease, showing that understanding lithium action is of high importance. In this paper we undertake first steps toward a systems approach by analyzing mutual enrichment between the interactomes of lithium-sensitive enzymes and the pathways associated with affective and neurodegenerative disorders. This work integrates information from two important databases, STRING and KEGG pathways. We find that for the majority of neurodegenerative disorders the mutual enrichment is many times greater than chance, reinforcing previous lines of evidence that lithium is an important influence on incidence of neurodegeneration. Our work suggests rational prioritization for which disorders are likely to be most sensitive to lithium and identifies genes that are likely to be useful targets for therapy adjunct to lithium. |
| first_indexed | 2024-12-10T15:08:36Z |
| format | Article |
| id | doaj.art-57d8fe3c2d8a4e189a0039c84f90347f |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-10T15:08:36Z |
| publishDate | 2018-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-57d8fe3c2d8a4e189a0039c84f90347f2022-12-22T01:43:59ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2018-12-011210.3389/fnins.2018.00933414262Systems Biology Understanding of the Effects of Lithium on Affective and Neurodegenerative DisordersWeihao Ge0Weihao Ge1Eric Jakobsson2Eric Jakobsson3Eric Jakobsson4National Center for Supercomputing Applications, Urbana-Champaign, Urbana, IL, United StatesCenter for Biophysics and Computational Biology, Urbana-Champaign, Urbana, IL, United StatesNational Center for Supercomputing Applications, Urbana-Champaign, Urbana, IL, United StatesCenter for Biophysics and Computational Biology, Urbana-Champaign, Urbana, IL, United StatesDepartment of Molecular and Integrative Physiology University of Illinois at Urbana-Champaign, Urbana, IL, United StatesLithium has many widely varying biochemical and phenomenological effects, suggesting that a systems biology approach is required to understand its action. Multiple lines of evidence point to lithium intake and consequent blood levels as important determinants of incidence of neurodegenerative disease, showing that understanding lithium action is of high importance. In this paper we undertake first steps toward a systems approach by analyzing mutual enrichment between the interactomes of lithium-sensitive enzymes and the pathways associated with affective and neurodegenerative disorders. This work integrates information from two important databases, STRING and KEGG pathways. We find that for the majority of neurodegenerative disorders the mutual enrichment is many times greater than chance, reinforcing previous lines of evidence that lithium is an important influence on incidence of neurodegeneration. Our work suggests rational prioritization for which disorders are likely to be most sensitive to lithium and identifies genes that are likely to be useful targets for therapy adjunct to lithium.https://www.frontiersin.org/article/10.3389/fnins.2018.00933/fulllithiumsystems biologyaffective disordersneurodegenerative disordersbiochemical pathwaysbiochemical networks |
| spellingShingle | Weihao Ge Weihao Ge Eric Jakobsson Eric Jakobsson Eric Jakobsson Systems Biology Understanding of the Effects of Lithium on Affective and Neurodegenerative Disorders Frontiers in Neuroscience lithium systems biology affective disorders neurodegenerative disorders biochemical pathways biochemical networks |
| title | Systems Biology Understanding of the Effects of Lithium on Affective and Neurodegenerative Disorders |
| title_full | Systems Biology Understanding of the Effects of Lithium on Affective and Neurodegenerative Disorders |
| title_fullStr | Systems Biology Understanding of the Effects of Lithium on Affective and Neurodegenerative Disorders |
| title_full_unstemmed | Systems Biology Understanding of the Effects of Lithium on Affective and Neurodegenerative Disorders |
| title_short | Systems Biology Understanding of the Effects of Lithium on Affective and Neurodegenerative Disorders |
| title_sort | systems biology understanding of the effects of lithium on affective and neurodegenerative disorders |
| topic | lithium systems biology affective disorders neurodegenerative disorders biochemical pathways biochemical networks |
| url | https://www.frontiersin.org/article/10.3389/fnins.2018.00933/full |
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