Efficacy of Trichloroacetic Acid in Patients with Alopecia Areata: A Clinico-Histopathological Study
Background: Alopecia areata is an autoimmune disorder caused by a breakdown in the follicular immune privilege system, resulting in non-scarring hair loss. Many therapeutic options have been tested with variable results. Aim of the work: To assess the efficacy of trichloroacetic acid [TCA] 35% in p...
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| Format: | Article |
| Language: | English |
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Al-Azhar University, Faculty of Medicine (Damietta)
2023-02-01
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| Series: | International Journal of Medical Arts |
| Subjects: | |
| Online Access: | https://ijma.journals.ekb.eg/article_297257_c7f6716ce2227ddb9d96938a184dcbd4.pdf |
| _version_ | 1797364430766342144 |
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| author | Hossam Anter Amr Zaky Ahmed Nouh Mohamed El-Khalawany |
| author_facet | Hossam Anter Amr Zaky Ahmed Nouh Mohamed El-Khalawany |
| author_sort | Hossam Anter |
| collection | DOAJ |
| description | Background: Alopecia areata is an autoimmune disorder caused by a breakdown in the follicular immune privilege system, resulting in non-scarring hair loss. Many therapeutic options have been tested with variable results. Aim of the work: To assess the efficacy of trichloroacetic acid [TCA] 35% in patients of alopecia areata.Patients and Methods: This prospective cross-sectional study included 40 patients recruited from department of dermatology and venereology, Al-Hussein hospital. Every patient was treated by 3 sessions of TCA 35% with one-month intervals. The assessment was done by clinical, trichoscopy, and histopathological examination.Results: The study included 40 patients, 22 males [55%] and18 females [45%]. The mean age of studied patients was 25.6 ± 8.6 years with a minimum age of 16 years and a maximum age of 50 years. The duration of the disease ranged between 2 months and 10 years with a mean duration of 2.7 ± 2.5 years. Thirty patients [75%] showed improvement at the end of TCA sessions.Conclusion: Based on our findings, topical application of TCA 35% is a safe and effective treatment option for patients with alopecia areata. Moreover, it can be used in wide areas of the scalp and cases of alopecia totalis. |
| first_indexed | 2024-03-08T16:35:13Z |
| format | Article |
| id | doaj.art-57d92ec1371d4c008b33ba574a2e6dd6 |
| institution | Directory Open Access Journal |
| issn | 2636-4174 2682-3780 |
| language | English |
| last_indexed | 2024-03-08T16:35:13Z |
| publishDate | 2023-02-01 |
| publisher | Al-Azhar University, Faculty of Medicine (Damietta) |
| record_format | Article |
| series | International Journal of Medical Arts |
| spelling | doaj.art-57d92ec1371d4c008b33ba574a2e6dd62024-01-05T19:36:12ZengAl-Azhar University, Faculty of Medicine (Damietta)International Journal of Medical Arts2636-41742682-37802023-02-01523033303810.21608/ijma.2023.197060.1634297257Efficacy of Trichloroacetic Acid in Patients with Alopecia Areata: A Clinico-Histopathological StudyHossam Anter0Amr Zaky1Ahmed Nouh2Mohamed El-Khalawany3Department of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, EgyptDepartment of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, EgyptDepartment of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, EgyptDepartment of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, EgyptBackground: Alopecia areata is an autoimmune disorder caused by a breakdown in the follicular immune privilege system, resulting in non-scarring hair loss. Many therapeutic options have been tested with variable results. Aim of the work: To assess the efficacy of trichloroacetic acid [TCA] 35% in patients of alopecia areata.Patients and Methods: This prospective cross-sectional study included 40 patients recruited from department of dermatology and venereology, Al-Hussein hospital. Every patient was treated by 3 sessions of TCA 35% with one-month intervals. The assessment was done by clinical, trichoscopy, and histopathological examination.Results: The study included 40 patients, 22 males [55%] and18 females [45%]. The mean age of studied patients was 25.6 ± 8.6 years with a minimum age of 16 years and a maximum age of 50 years. The duration of the disease ranged between 2 months and 10 years with a mean duration of 2.7 ± 2.5 years. Thirty patients [75%] showed improvement at the end of TCA sessions.Conclusion: Based on our findings, topical application of TCA 35% is a safe and effective treatment option for patients with alopecia areata. Moreover, it can be used in wide areas of the scalp and cases of alopecia totalis.https://ijma.journals.ekb.eg/article_297257_c7f6716ce2227ddb9d96938a184dcbd4.pdfalopeciahair lossalopecia areatatrichloroacetic acid |
| spellingShingle | Hossam Anter Amr Zaky Ahmed Nouh Mohamed El-Khalawany Efficacy of Trichloroacetic Acid in Patients with Alopecia Areata: A Clinico-Histopathological Study International Journal of Medical Arts alopecia hair loss alopecia areata trichloroacetic acid |
| title | Efficacy of Trichloroacetic Acid in Patients with Alopecia Areata: A Clinico-Histopathological Study |
| title_full | Efficacy of Trichloroacetic Acid in Patients with Alopecia Areata: A Clinico-Histopathological Study |
| title_fullStr | Efficacy of Trichloroacetic Acid in Patients with Alopecia Areata: A Clinico-Histopathological Study |
| title_full_unstemmed | Efficacy of Trichloroacetic Acid in Patients with Alopecia Areata: A Clinico-Histopathological Study |
| title_short | Efficacy of Trichloroacetic Acid in Patients with Alopecia Areata: A Clinico-Histopathological Study |
| title_sort | efficacy of trichloroacetic acid in patients with alopecia areata a clinico histopathological study |
| topic | alopecia hair loss alopecia areata trichloroacetic acid |
| url | https://ijma.journals.ekb.eg/article_297257_c7f6716ce2227ddb9d96938a184dcbd4.pdf |
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