In vivo cytogenotoxicity testing of isotretinoin by the micronucleus assay in the blood of male Sprague-Dawley rats Isotretinoin is cytotoxic and genotoxic

In vivo cytogenotoxicity testing of isotretinoin by the micronucleus assay in the blood of male Sprague-Dawley rats Isotretinoin is cytotoxic and genotoxic

Isotretinoin (ISO), one of vitamin A-derived retinoids, is comparatively the most widely prescribed drug in acne vulgaris pathogenesis. Despite its excellent therapeutic success, the systemic use of this drug showed undesirable serious side effects such as teratogenesis, oxidative stress, and genot...

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Bibliographic Details
Main Authors: Ahmad Khalil, Hasan Abo Siam, Mai Daradkeh, Amneh Alrabie
Format: Article
Language:English
Published: University of Sarajevo, Institute for Genetic Engineering and Biotechnology 2022-12-01
Series:Genetics & Applications
Subjects:
Genotoxicity
Isotretinoin
micronucleus test
polychromatic /normochromatic erythrocytes ratio
Online Access:https://genapp.ba/editions/index.php/journal/article/view/151

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