Renoprotective Effect of <i>Laminaria japonica</i> Polysaccharide in Adenine-Induced Chronic Renal Failure
Chronic renal failure (CRF) is a major public health problem worldwide. In this work, we investigated the effects of a purified <i>Laminaria japonica</i> polysaccharide (LJP61A) on renal function using an adenine-induced CRF mice model. Results exhibited that adenine treatment caused ser...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-04-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/24/8/1491 |
| _version_ | 1819176965870977024 |
|---|---|
| author | Miao Long Qiang-Ming Li Qing Fang Li-Hua Pan Xue-Qiang Zha Jian-Ping Luo |
| author_facet | Miao Long Qiang-Ming Li Qing Fang Li-Hua Pan Xue-Qiang Zha Jian-Ping Luo |
| author_sort | Miao Long |
| collection | DOAJ |
| description | Chronic renal failure (CRF) is a major public health problem worldwide. In this work, we investigated the effects of a purified <i>Laminaria japonica</i> polysaccharide (LJP61A) on renal function using an adenine-induced CRF mice model. Results exhibited that adenine treatment caused serious renal pathological damages and elevation of serum creatinine and blood urea nitrogen of mice. However, these changes could be significantly reversed by the administration of LJP61A in a dose-dependent manner. Additionally, LJP61A could dramatically reduce weight loss, improve the urine biochemical index, and regulate the electrolyte disturbance of CRF mice. These results suggest that the renal function of adenine-induced CRF mice can be improved by LJP61A, which might be developed into a potential therapeutic agent for CRF patients. |
| first_indexed | 2024-12-22T21:19:09Z |
| format | Article |
| id | doaj.art-57db4b2b1c344c6ba8030fd1214a3b4d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T21:19:09Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-57db4b2b1c344c6ba8030fd1214a3b4d2022-12-21T18:12:15ZengMDPI AGMolecules1420-30492019-04-01248149110.3390/molecules24081491molecules24081491Renoprotective Effect of <i>Laminaria japonica</i> Polysaccharide in Adenine-Induced Chronic Renal FailureMiao Long0Qiang-Ming Li1Qing Fang2Li-Hua Pan3Xue-Qiang Zha4Jian-Ping Luo5Engineering Research Center of Bio-process of Ministry of Education of China, Hefei University of Technology, Hefei 230009, ChinaEngineering Research Center of Bio-process of Ministry of Education of China, Hefei University of Technology, Hefei 230009, ChinaEngineering Research Center of Bio-process of Ministry of Education of China, Hefei University of Technology, Hefei 230009, ChinaEngineering Research Center of Bio-process of Ministry of Education of China, Hefei University of Technology, Hefei 230009, ChinaEngineering Research Center of Bio-process of Ministry of Education of China, Hefei University of Technology, Hefei 230009, ChinaEngineering Research Center of Bio-process of Ministry of Education of China, Hefei University of Technology, Hefei 230009, ChinaChronic renal failure (CRF) is a major public health problem worldwide. In this work, we investigated the effects of a purified <i>Laminaria japonica</i> polysaccharide (LJP61A) on renal function using an adenine-induced CRF mice model. Results exhibited that adenine treatment caused serious renal pathological damages and elevation of serum creatinine and blood urea nitrogen of mice. However, these changes could be significantly reversed by the administration of LJP61A in a dose-dependent manner. Additionally, LJP61A could dramatically reduce weight loss, improve the urine biochemical index, and regulate the electrolyte disturbance of CRF mice. These results suggest that the renal function of adenine-induced CRF mice can be improved by LJP61A, which might be developed into a potential therapeutic agent for CRF patients.https://www.mdpi.com/1420-3049/24/8/1491<i>Laminaria japonica</i>polysaccharidechronic renal failure |
| spellingShingle | Miao Long Qiang-Ming Li Qing Fang Li-Hua Pan Xue-Qiang Zha Jian-Ping Luo Renoprotective Effect of <i>Laminaria japonica</i> Polysaccharide in Adenine-Induced Chronic Renal Failure Molecules <i>Laminaria japonica</i> polysaccharide chronic renal failure |
| title | Renoprotective Effect of <i>Laminaria japonica</i> Polysaccharide in Adenine-Induced Chronic Renal Failure |
| title_full | Renoprotective Effect of <i>Laminaria japonica</i> Polysaccharide in Adenine-Induced Chronic Renal Failure |
| title_fullStr | Renoprotective Effect of <i>Laminaria japonica</i> Polysaccharide in Adenine-Induced Chronic Renal Failure |
| title_full_unstemmed | Renoprotective Effect of <i>Laminaria japonica</i> Polysaccharide in Adenine-Induced Chronic Renal Failure |
| title_short | Renoprotective Effect of <i>Laminaria japonica</i> Polysaccharide in Adenine-Induced Chronic Renal Failure |
| title_sort | renoprotective effect of i laminaria japonica i polysaccharide in adenine induced chronic renal failure |
| topic | <i>Laminaria japonica</i> polysaccharide chronic renal failure |
| url | https://www.mdpi.com/1420-3049/24/8/1491 |
| work_keys_str_mv | AT miaolong renoprotectiveeffectofilaminariajaponicaipolysaccharideinadenineinducedchronicrenalfailure AT qiangmingli renoprotectiveeffectofilaminariajaponicaipolysaccharideinadenineinducedchronicrenalfailure AT qingfang renoprotectiveeffectofilaminariajaponicaipolysaccharideinadenineinducedchronicrenalfailure AT lihuapan renoprotectiveeffectofilaminariajaponicaipolysaccharideinadenineinducedchronicrenalfailure AT xueqiangzha renoprotectiveeffectofilaminariajaponicaipolysaccharideinadenineinducedchronicrenalfailure AT jianpingluo renoprotectiveeffectofilaminariajaponicaipolysaccharideinadenineinducedchronicrenalfailure |