CD36: The Bridge between Lipids and Tumors
It has been found that the development of some cancers can be attributed to obesity, which is associated with the excessive intake of lipids. Cancer cells undergo metabolic reprogramming, shifting from utilizing glucose to fatty acids (FAs) for energy. CD36, a lipid transporter, is highly expressed...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/2/531 |
| _version_ | 1797339476368818176 |
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| author | Xuan Zhou Manman Su Jungu Lu Deming Li Xinhui Niu Yi Wang |
| author_facet | Xuan Zhou Manman Su Jungu Lu Deming Li Xinhui Niu Yi Wang |
| author_sort | Xuan Zhou |
| collection | DOAJ |
| description | It has been found that the development of some cancers can be attributed to obesity, which is associated with the excessive intake of lipids. Cancer cells undergo metabolic reprogramming, shifting from utilizing glucose to fatty acids (FAs) for energy. CD36, a lipid transporter, is highly expressed in certain kinds of cancer cells. High expressions of CD36 in tumor cells triggers FA uptake and lipid accumulation, promoting rapid tumor growth and initiating metastasis. Meanwhile, immune cells in the tumor microenvironment overexpress CD36 and undergo metabolic reprogramming. CD36-mediated FA uptake leads to lipid accumulation and has immunosuppressive effects. This paper reviews the types of FAs associated with cancer, high expressions of CD36 that promote cancer development and progression, effects of CD36 on different immune cells in the tumor microenvironment, and the current status of CD36 as a therapeutic target for the treatment of tumors with high CD36 expression. |
| first_indexed | 2024-03-08T09:48:41Z |
| format | Article |
| id | doaj.art-57db9b5b099f47349a7dc81876f60195 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-08T09:48:41Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-57db9b5b099f47349a7dc81876f601952024-01-29T14:09:21ZengMDPI AGMolecules1420-30492024-01-0129253110.3390/molecules29020531CD36: The Bridge between Lipids and TumorsXuan Zhou0Manman Su1Jungu Lu2Deming Li3Xinhui Niu4Yi Wang5Department of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun 130012, ChinaDepartment of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun 130012, ChinaDepartment of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun 130012, ChinaDepartment of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun 130012, ChinaDepartment of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun 130012, ChinaDepartment of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun 130012, ChinaIt has been found that the development of some cancers can be attributed to obesity, which is associated with the excessive intake of lipids. Cancer cells undergo metabolic reprogramming, shifting from utilizing glucose to fatty acids (FAs) for energy. CD36, a lipid transporter, is highly expressed in certain kinds of cancer cells. High expressions of CD36 in tumor cells triggers FA uptake and lipid accumulation, promoting rapid tumor growth and initiating metastasis. Meanwhile, immune cells in the tumor microenvironment overexpress CD36 and undergo metabolic reprogramming. CD36-mediated FA uptake leads to lipid accumulation and has immunosuppressive effects. This paper reviews the types of FAs associated with cancer, high expressions of CD36 that promote cancer development and progression, effects of CD36 on different immune cells in the tumor microenvironment, and the current status of CD36 as a therapeutic target for the treatment of tumors with high CD36 expression.https://www.mdpi.com/1420-3049/29/2/531CD36fatty acidimmunosuppresslipidmetastasis-initiating cells |
| spellingShingle | Xuan Zhou Manman Su Jungu Lu Deming Li Xinhui Niu Yi Wang CD36: The Bridge between Lipids and Tumors Molecules CD36 fatty acid immunosuppress lipid metastasis-initiating cells |
| title | CD36: The Bridge between Lipids and Tumors |
| title_full | CD36: The Bridge between Lipids and Tumors |
| title_fullStr | CD36: The Bridge between Lipids and Tumors |
| title_full_unstemmed | CD36: The Bridge between Lipids and Tumors |
| title_short | CD36: The Bridge between Lipids and Tumors |
| title_sort | cd36 the bridge between lipids and tumors |
| topic | CD36 fatty acid immunosuppress lipid metastasis-initiating cells |
| url | https://www.mdpi.com/1420-3049/29/2/531 |
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