Endometrial Perivascular Progenitor Cells and Uterus Regeneration
Ovarian steroid-regulated cyclical regeneration of the endometrium is crucial for endometrial receptivity and embryo implantation, and it is dependent on the dynamic remodeling of the endometrial vasculature. Perivascular cells, including pericytes surrounding capillaries and microvessels and advent...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/11/6/477 |
| _version_ | 1797532522657087488 |
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| author | Shiyuan Li Lijun Ding |
| author_facet | Shiyuan Li Lijun Ding |
| author_sort | Shiyuan Li |
| collection | DOAJ |
| description | Ovarian steroid-regulated cyclical regeneration of the endometrium is crucial for endometrial receptivity and embryo implantation, and it is dependent on the dynamic remodeling of the endometrial vasculature. Perivascular cells, including pericytes surrounding capillaries and microvessels and adventitial cells located in the outermost layer of large vessels, show properties of mesenchymal stem cells, and they are thus promising candidates for uterine regeneration. In this review, we discuss the structure and functions of the endometrial blood vasculature and their roles in endometrial regeneration, the main biomarkers and characteristics of perivascular cells in the endometrium, and stem cell-based angiogenetic therapy for Asherman’s syndrome. |
| first_indexed | 2024-03-10T11:00:24Z |
| format | Article |
| id | doaj.art-57dbdb319b5546b286e7cf7821596f38 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T11:00:24Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-57dbdb319b5546b286e7cf7821596f382023-11-21T21:32:58ZengMDPI AGJournal of Personalized Medicine2075-44262021-05-0111647710.3390/jpm11060477Endometrial Perivascular Progenitor Cells and Uterus RegenerationShiyuan Li0Lijun Ding1Center for Reproductive Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, ChinaCenter for Reproductive Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, ChinaOvarian steroid-regulated cyclical regeneration of the endometrium is crucial for endometrial receptivity and embryo implantation, and it is dependent on the dynamic remodeling of the endometrial vasculature. Perivascular cells, including pericytes surrounding capillaries and microvessels and adventitial cells located in the outermost layer of large vessels, show properties of mesenchymal stem cells, and they are thus promising candidates for uterine regeneration. In this review, we discuss the structure and functions of the endometrial blood vasculature and their roles in endometrial regeneration, the main biomarkers and characteristics of perivascular cells in the endometrium, and stem cell-based angiogenetic therapy for Asherman’s syndrome.https://www.mdpi.com/2075-4426/11/6/477endometrial stem cellperivascular cellCD146 pericyteCD34 adventitial cellAsherman’s syndrome |
| spellingShingle | Shiyuan Li Lijun Ding Endometrial Perivascular Progenitor Cells and Uterus Regeneration Journal of Personalized Medicine endometrial stem cell perivascular cell CD146 pericyte CD34 adventitial cell Asherman’s syndrome |
| title | Endometrial Perivascular Progenitor Cells and Uterus Regeneration |
| title_full | Endometrial Perivascular Progenitor Cells and Uterus Regeneration |
| title_fullStr | Endometrial Perivascular Progenitor Cells and Uterus Regeneration |
| title_full_unstemmed | Endometrial Perivascular Progenitor Cells and Uterus Regeneration |
| title_short | Endometrial Perivascular Progenitor Cells and Uterus Regeneration |
| title_sort | endometrial perivascular progenitor cells and uterus regeneration |
| topic | endometrial stem cell perivascular cell CD146 pericyte CD34 adventitial cell Asherman’s syndrome |
| url | https://www.mdpi.com/2075-4426/11/6/477 |
| work_keys_str_mv | AT shiyuanli endometrialperivascularprogenitorcellsanduterusregeneration AT lijunding endometrialperivascularprogenitorcellsanduterusregeneration |