Blocking GSK3β-mediated dynamin1 phosphorylation enhances BDNF-dependent TrkB endocytosis and the protective effects of BDNF in neuronal and mouse models of Alzheimer's disease

Blocking GSK3β-mediated dynamin1 phosphorylation enhances BDNF-dependent TrkB endocytosis and the protective effects of BDNF in neuronal and mouse models of Alzheimer's disease

Endocytosis of tropomyosin related kinase B (TrkB) receptors has critical roles in brain-derived neurotrophic factor (BDNF) mediated signal transduction and biological function, however the mechanism that is governing TrkB endocytosis is still not completely understood. In this study, we showed that...

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Bibliographic Details
Main Authors: Xiang-Hua Liu, Zhao Geng, Jing Yan, Ting Li, Qun Chen, Qun-Ye Zhang, Zhe-Yu Chen
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Neurobiology of Disease
Subjects:
Beta-amyloid
GSK3β
Dynamin1
BDNF
Endocytosis
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003660

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