Effects of Cryopreservation Duration on the Outcome of Single-Unit Cord Blood Transplantation
Cryopreservation is widely used in umbilical cord blood (UCB) banking, yet its impact on progenitor cell function remains largely unaddressed. It is unknown whether long-term cryopreservation affects UCB transplantation outcomes. Herein, we evaluated the impact of UCB age on clinical outcomes and in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-03-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/0963689717753187 |
| _version_ | 1818142972093399040 |
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| author | Tang-Her Jaing Shih-Hsiang Chen Yu-Chuan Wen Tsung-Yen Chang Ya-Chun Yang Pei-Kwei Tsay |
| author_facet | Tang-Her Jaing Shih-Hsiang Chen Yu-Chuan Wen Tsung-Yen Chang Ya-Chun Yang Pei-Kwei Tsay |
| author_sort | Tang-Her Jaing |
| collection | DOAJ |
| description | Cryopreservation is widely used in umbilical cord blood (UCB) banking, yet its impact on progenitor cell function remains largely unaddressed. It is unknown whether long-term cryopreservation affects UCB transplantation outcomes. Herein, we evaluated the impact of UCB age on clinical outcomes and investigated the effect of cryopreservation duration of UCB on hematopoietic potency in 91 patients receiving single cord blood transplantations. UCB cryopreservation duration was 0.7 to 13.4 y. The most common indication of transplant was thalassemia (48%). There was no significant association between cryopreservation duration and neutrophil engraftment probability ( P = 0.475). Cryopreservation duration did not affect the post-thaw viability and subsequent neutrophil engraftment rate. Therefore, UCB units can undergo cryopreservation for at least 8 y with no impact on clinical outcomes. |
| first_indexed | 2024-12-11T11:24:16Z |
| format | Article |
| id | doaj.art-57dd234014b4482bb8f0b6e27723b23d |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-12-11T11:24:16Z |
| publishDate | 2018-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-57dd234014b4482bb8f0b6e27723b23d2022-12-22T01:09:04ZengSAGE PublishingCell Transplantation0963-68971555-38922018-03-012710.1177/0963689717753187Effects of Cryopreservation Duration on the Outcome of Single-Unit Cord Blood TransplantationTang-Her Jaing0Shih-Hsiang Chen1Yu-Chuan Wen2Tsung-Yen Chang3Ya-Chun Yang4Pei-Kwei Tsay5 Department of Pediatrics, Chang Gung Children’s Hospital, Chang Gung University, Taoyuan, Taiwan Department of Pediatrics, Chang Gung Children’s Hospital, Chang Gung University, Taoyuan, Taiwan Department of Nursing, Chang Gung Memorial Hospital, Taoyuan, Taiwan Department of Pediatrics, Chang Gung Children’s Hospital, Chang Gung University, Taoyuan, Taiwan Department of Nursing, Chang Gung Memorial Hospital, Taoyuan, Taiwan Department of Public Health and Center of Biostatistics, College of Medicine, Chang Gung University, Taoyuan, TaiwanCryopreservation is widely used in umbilical cord blood (UCB) banking, yet its impact on progenitor cell function remains largely unaddressed. It is unknown whether long-term cryopreservation affects UCB transplantation outcomes. Herein, we evaluated the impact of UCB age on clinical outcomes and investigated the effect of cryopreservation duration of UCB on hematopoietic potency in 91 patients receiving single cord blood transplantations. UCB cryopreservation duration was 0.7 to 13.4 y. The most common indication of transplant was thalassemia (48%). There was no significant association between cryopreservation duration and neutrophil engraftment probability ( P = 0.475). Cryopreservation duration did not affect the post-thaw viability and subsequent neutrophil engraftment rate. Therefore, UCB units can undergo cryopreservation for at least 8 y with no impact on clinical outcomes.https://doi.org/10.1177/0963689717753187 |
| spellingShingle | Tang-Her Jaing Shih-Hsiang Chen Yu-Chuan Wen Tsung-Yen Chang Ya-Chun Yang Pei-Kwei Tsay Effects of Cryopreservation Duration on the Outcome of Single-Unit Cord Blood Transplantation Cell Transplantation |
| title | Effects of Cryopreservation Duration on the Outcome of Single-Unit Cord Blood Transplantation |
| title_full | Effects of Cryopreservation Duration on the Outcome of Single-Unit Cord Blood Transplantation |
| title_fullStr | Effects of Cryopreservation Duration on the Outcome of Single-Unit Cord Blood Transplantation |
| title_full_unstemmed | Effects of Cryopreservation Duration on the Outcome of Single-Unit Cord Blood Transplantation |
| title_short | Effects of Cryopreservation Duration on the Outcome of Single-Unit Cord Blood Transplantation |
| title_sort | effects of cryopreservation duration on the outcome of single unit cord blood transplantation |
| url | https://doi.org/10.1177/0963689717753187 |
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