Dual Checkpoint Aptamer Immunotherapy: Unveiling Tailored Cancer Treatment Targeting CTLA-4 and NKG2A

Dual Checkpoint Aptamer Immunotherapy: Unveiling Tailored Cancer Treatment Targeting CTLA-4 and NKG2A

Recent strides in immunotherapy have illuminated the crucial role of CTLA-4 and PD-1/PD-L1 pathways in contemporary oncology, presenting both promises and challenges in response rates and adverse effects. This study employs a computational biology tool (in silico approach) to craft aptamers capable...

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Bibliographic Details
Main Authors: Mohamad Ammar Ayass, Trivendra Tripathi, Natalya Griko, Tutku Okyay, Ramya Ramankutty Nair, Jin Zhang, Kevin Zhu, Kristen Melendez, Victor Pashkov, Lina Abi-Mosleh
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Cancers
Subjects:
aptamer
cancer
CTLA-4
NKG2A
checkpoint
immunotherapy
Online Access:https://www.mdpi.com/2072-6694/16/5/1041

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