Electrolyte disturbances in children receiving omeprazole for gastroesophageal reflux disease
Background: Gastroesophageal reflux disease (GERD) is one of the common gastrointestinal diseases with various side effects. Proton pump inhibitor (PPI) drugs are widely used for their treatment and long-term ingestion, which results in an electrolyte imbalance. This study investigates the changes i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Journal of Research in Medical Sciences |
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| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2020;volume=25;issue=1;spage=106;epage=106;aulast=Famouri |
| _version_ | 1818725647194783744 |
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| author | Fatemeh Famouri Forough Derakhshani Yahya Madihi Armindokht Shahsanai |
| author_facet | Fatemeh Famouri Forough Derakhshani Yahya Madihi Armindokht Shahsanai |
| author_sort | Fatemeh Famouri |
| collection | DOAJ |
| description | Background: Gastroesophageal reflux disease (GERD) is one of the common gastrointestinal diseases with various side effects. Proton pump inhibitor (PPI) drugs are widely used for their treatment and long-term ingestion, which results in an electrolyte imbalance. This study investigates the changes in serum magnesium, calcium, sodium, and potassium after long-term use of omeprazole in children. Materials and Methods: This cross-sectional study was conducted in 2016–2017 on 97 children and adolescents, aged 1–15 years, with GERD, in Isfahan, Iran. Enrolled were patients visiting a referral pediatric gastroenterology clinic (Imam Hossein and Amin Hospitals) examined by an academic pediatric gastroenterologist. Before and 4 weeks after omeprazole administration, clinical manifestations including lethargy, muscle spasm, dyspnea, nausea, vomiting, abnormal heartbeat and deep tendon reflexes, and Chvostek and Trousseau signs were recorded in a data-gathering form. In addition, fasting serum magnesium, calcium, sodium, and potassium were measured. Results: The McNemar test results showed that omeprazole can reduce sodium, calcium, and magnesium levels statistically significantly (P < 0.05), but potassium levels do not have a meaningful reduction (P > 0.05). Conclusion: Consumption of omeprazole might cause asymptomatic hypomagnesemia, hypocalcemia, and hypernatremia in children. Such side effects should be considered in the follow-up of children under treatment with this medication. |
| first_indexed | 2024-12-17T21:45:38Z |
| format | Article |
| id | doaj.art-57e22a38215c49e09fc5070383294c9e |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-17T21:45:38Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-57e22a38215c49e09fc5070383294c9e2022-12-21T21:31:28ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362020-01-0125110610610.4103/jrms.JRMS_637_18Electrolyte disturbances in children receiving omeprazole for gastroesophageal reflux diseaseFatemeh FamouriForough DerakhshaniYahya MadihiArmindokht ShahsanaiBackground: Gastroesophageal reflux disease (GERD) is one of the common gastrointestinal diseases with various side effects. Proton pump inhibitor (PPI) drugs are widely used for their treatment and long-term ingestion, which results in an electrolyte imbalance. This study investigates the changes in serum magnesium, calcium, sodium, and potassium after long-term use of omeprazole in children. Materials and Methods: This cross-sectional study was conducted in 2016–2017 on 97 children and adolescents, aged 1–15 years, with GERD, in Isfahan, Iran. Enrolled were patients visiting a referral pediatric gastroenterology clinic (Imam Hossein and Amin Hospitals) examined by an academic pediatric gastroenterologist. Before and 4 weeks after omeprazole administration, clinical manifestations including lethargy, muscle spasm, dyspnea, nausea, vomiting, abnormal heartbeat and deep tendon reflexes, and Chvostek and Trousseau signs were recorded in a data-gathering form. In addition, fasting serum magnesium, calcium, sodium, and potassium were measured. Results: The McNemar test results showed that omeprazole can reduce sodium, calcium, and magnesium levels statistically significantly (P < 0.05), but potassium levels do not have a meaningful reduction (P > 0.05). Conclusion: Consumption of omeprazole might cause asymptomatic hypomagnesemia, hypocalcemia, and hypernatremia in children. Such side effects should be considered in the follow-up of children under treatment with this medication.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2020;volume=25;issue=1;spage=106;epage=106;aulast=Famourielectrolyte imbalanceomeprazoleproton pump inhibitors |
| spellingShingle | Fatemeh Famouri Forough Derakhshani Yahya Madihi Armindokht Shahsanai Electrolyte disturbances in children receiving omeprazole for gastroesophageal reflux disease Journal of Research in Medical Sciences electrolyte imbalance omeprazole proton pump inhibitors |
| title | Electrolyte disturbances in children receiving omeprazole for gastroesophageal reflux disease |
| title_full | Electrolyte disturbances in children receiving omeprazole for gastroesophageal reflux disease |
| title_fullStr | Electrolyte disturbances in children receiving omeprazole for gastroesophageal reflux disease |
| title_full_unstemmed | Electrolyte disturbances in children receiving omeprazole for gastroesophageal reflux disease |
| title_short | Electrolyte disturbances in children receiving omeprazole for gastroesophageal reflux disease |
| title_sort | electrolyte disturbances in children receiving omeprazole for gastroesophageal reflux disease |
| topic | electrolyte imbalance omeprazole proton pump inhibitors |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2020;volume=25;issue=1;spage=106;epage=106;aulast=Famouri |
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