Deciphering the Molecular Nature of Ovarian Cancer Biomarker CA125
The ovarian cancer biomarker CA125 has been extensively investigated over the last 30 years. The knowledge about the exact molecular nature of this protein, however, remains fragmented. This review provides an overview of the structural research regarding CA125, and presents an orthogonal verificati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-08-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1422-0067/13/8/10568 |
| _version_ | 1811268414416617472 |
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| author | Peter Hoffmann Martin K. Oehler Florian Weiland Karina Martin |
| author_facet | Peter Hoffmann Martin K. Oehler Florian Weiland Karina Martin |
| author_sort | Peter Hoffmann |
| collection | DOAJ |
| description | The ovarian cancer biomarker CA125 has been extensively investigated over the last 30 years. The knowledge about the exact molecular nature of this protein, however, remains fragmented. This review provides an overview of the structural research regarding CA125, and presents an orthogonal verification method to confirm the identity of this molecule. The need for independent identification of CA125 is exemplified by several reports where mutually exclusive data concerning the existence of isoforms and the glycan moieties is presented. Mass spectrometry can overcome the pitfalls of a single detection/identification method such as antibody probing. Independent verification of CA125 identity in characterization studies will help establish a refined model of its molecular structure that will promote the development of new approaches for diagnosis, prognosis and therapy of ovarian cancer. |
| first_indexed | 2024-04-12T21:21:23Z |
| format | Article |
| id | doaj.art-57e2a1310bea4d9b9a1eff21ae1ed129 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T21:21:23Z |
| publishDate | 2012-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-57e2a1310bea4d9b9a1eff21ae1ed1292022-12-22T03:16:17ZengMDPI AGInternational Journal of Molecular Sciences1422-00672012-08-01138105681058210.3390/ijms130810568Deciphering the Molecular Nature of Ovarian Cancer Biomarker CA125Peter HoffmannMartin K. OehlerFlorian WeilandKarina MartinThe ovarian cancer biomarker CA125 has been extensively investigated over the last 30 years. The knowledge about the exact molecular nature of this protein, however, remains fragmented. This review provides an overview of the structural research regarding CA125, and presents an orthogonal verification method to confirm the identity of this molecule. The need for independent identification of CA125 is exemplified by several reports where mutually exclusive data concerning the existence of isoforms and the glycan moieties is presented. Mass spectrometry can overcome the pitfalls of a single detection/identification method such as antibody probing. Independent verification of CA125 identity in characterization studies will help establish a refined model of its molecular structure that will promote the development of new approaches for diagnosis, prognosis and therapy of ovarian cancer.http://www.mdpi.com/1422-0067/13/8/10568CA125MUC16ovarian cancerbiomarkermass spectrometry |
| spellingShingle | Peter Hoffmann Martin K. Oehler Florian Weiland Karina Martin Deciphering the Molecular Nature of Ovarian Cancer Biomarker CA125 International Journal of Molecular Sciences CA125 MUC16 ovarian cancer biomarker mass spectrometry |
| title | Deciphering the Molecular Nature of Ovarian Cancer Biomarker CA125 |
| title_full | Deciphering the Molecular Nature of Ovarian Cancer Biomarker CA125 |
| title_fullStr | Deciphering the Molecular Nature of Ovarian Cancer Biomarker CA125 |
| title_full_unstemmed | Deciphering the Molecular Nature of Ovarian Cancer Biomarker CA125 |
| title_short | Deciphering the Molecular Nature of Ovarian Cancer Biomarker CA125 |
| title_sort | deciphering the molecular nature of ovarian cancer biomarker ca125 |
| topic | CA125 MUC16 ovarian cancer biomarker mass spectrometry |
| url | http://www.mdpi.com/1422-0067/13/8/10568 |
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