Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix–Loop–Helix Transcription Factors
The basic helix–loop–helix transcription factor (bHLH TF) family is involved in tissue development, cell differentiation, and disease. These factors have transcriptionally positive, negative, and inactive functions by combining dimeric interactions among family members. The best known bHLH TFs are t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/23/12855 |
| _version_ | 1797507774852104192 |
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| author | Ana Lilia Torres-Machorro |
| author_facet | Ana Lilia Torres-Machorro |
| author_sort | Ana Lilia Torres-Machorro |
| collection | DOAJ |
| description | The basic helix–loop–helix transcription factor (bHLH TF) family is involved in tissue development, cell differentiation, and disease. These factors have transcriptionally positive, negative, and inactive functions by combining dimeric interactions among family members. The best known bHLH TFs are the E-protein homodimers and heterodimers with the tissue-specific TFs or ID proteins. These cooperative and dynamic interactions result in a complex transcriptional network that helps define the cell’s fate. Here, the reported dimeric interactions of 67 vertebrate bHLH TFs with other family members are summarized in tables, including specifications of the experimental techniques that defined the dimers. The compilation of these extensive data underscores homodimers of tissue-specific bHLH TFs as a central part of the bHLH regulatory network, with relevant positive and negative transcriptional regulatory roles. Furthermore, some sequence-specific TFs can also form transcriptionally inactive heterodimers with each other. The function, classification, and developmental role for all vertebrate bHLH TFs in four major classes are detailed. |
| first_indexed | 2024-03-10T04:53:14Z |
| format | Article |
| id | doaj.art-57e3dacf473e4e25af2bb3d490e155dd |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:53:14Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-57e3dacf473e4e25af2bb3d490e155dd2023-11-23T02:29:16ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122231285510.3390/ijms222312855Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix–Loop–Helix Transcription FactorsAna Lilia Torres-Machorro0Laboratorio de Biología Celular, Departamento de Investigación en Fibrosis Pulmonar, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Tlalpan, Mexico City 14080, MexicoThe basic helix–loop–helix transcription factor (bHLH TF) family is involved in tissue development, cell differentiation, and disease. These factors have transcriptionally positive, negative, and inactive functions by combining dimeric interactions among family members. The best known bHLH TFs are the E-protein homodimers and heterodimers with the tissue-specific TFs or ID proteins. These cooperative and dynamic interactions result in a complex transcriptional network that helps define the cell’s fate. Here, the reported dimeric interactions of 67 vertebrate bHLH TFs with other family members are summarized in tables, including specifications of the experimental techniques that defined the dimers. The compilation of these extensive data underscores homodimers of tissue-specific bHLH TFs as a central part of the bHLH regulatory network, with relevant positive and negative transcriptional regulatory roles. Furthermore, some sequence-specific TFs can also form transcriptionally inactive heterodimers with each other. The function, classification, and developmental role for all vertebrate bHLH TFs in four major classes are detailed.https://www.mdpi.com/1422-0067/22/23/12855transcriptional regulationE-proteinsID proteinssequence-specific transcription factorsDNA bindingClass II bHLH transcription factors |
| spellingShingle | Ana Lilia Torres-Machorro Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix–Loop–Helix Transcription Factors International Journal of Molecular Sciences transcriptional regulation E-proteins ID proteins sequence-specific transcription factors DNA binding Class II bHLH transcription factors |
| title | Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix–Loop–Helix Transcription Factors |
| title_full | Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix–Loop–Helix Transcription Factors |
| title_fullStr | Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix–Loop–Helix Transcription Factors |
| title_full_unstemmed | Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix–Loop–Helix Transcription Factors |
| title_short | Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix–Loop–Helix Transcription Factors |
| title_sort | homodimeric and heterodimeric interactions among vertebrate basic helix loop helix transcription factors |
| topic | transcriptional regulation E-proteins ID proteins sequence-specific transcription factors DNA binding Class II bHLH transcription factors |
| url | https://www.mdpi.com/1422-0067/22/23/12855 |
| work_keys_str_mv | AT analiliatorresmachorro homodimericandheterodimericinteractionsamongvertebratebasichelixloophelixtranscriptionfactors |