7.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson’s disease patients
OBJECTIVES: The pedunculopontine nucleus (PPN) is considered a promising new target for neurostimulation in Parkinson’s disease (PD) patients with postural instability and gait disturbance that is refractory to other treatment modalities. However, the PPN is typically difficult to visualize with mag...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2019-04-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322019000100221&lng=en&tlng=en |
| _version_ | 1818111860575043584 |
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| author | Jia-Wei Wang Fei Cong Yan Zhuo Lin Chen Bo Wang Yu-Qing Zhang |
| author_facet | Jia-Wei Wang Fei Cong Yan Zhuo Lin Chen Bo Wang Yu-Qing Zhang |
| author_sort | Jia-Wei Wang |
| collection | DOAJ |
| description | OBJECTIVES: The pedunculopontine nucleus (PPN) is considered a promising new target for neurostimulation in Parkinson’s disease (PD) patients with postural instability and gait disturbance that is refractory to other treatment modalities. However, the PPN is typically difficult to visualize with magnetic resonance imaging (MRI) at clinical field strengths, which greatly limits the PPN as a viable surgical target for deep brain stimulation (DBS). Thus, the aim of this study is to directly visualize the PPN based on 7.0T ultrahigh-field MRI. METHODS: Five PD patients were enrolled and scanned using the MP2RAGE sequence on a 7.0T ultrahigh-field MRI scanner. Then, the MP2RAGE sequences were imported into a commercially available navigation system. The coordinates of the directly localized PPN poles were recorded in the navigation system relative to the anterior commissure-posterior commissure plane. RESULTS: Our results indicated that the PPN presented intermediate signal intensity in the 7.0T ultrahigh-field MR images in comparison with the surrounding structure, such as the hypo-intensity of the periaqueductal gray and the hyperintensity of the neighboring white matter tracts, in PD patients. The mean coordinates for the rostral and caudal poles of PPN were 6.50 mm and 7.20 mm lateral, 1.58 mm and 2.21 mm posterior, and 8.89 mm and 13.83 mm relative to the posterior commissure. CONCLUSION: Our findings provide, for the first time, direct visualization of the PPN using the MP2RAGE sequence on a 7.0T ultrahigh-field MRI, which may improve the accuracy of stereotactic targeting of the PPN and improve the outcomes in patients undergoing DBS. |
| first_indexed | 2024-12-11T03:09:45Z |
| format | Article |
| id | doaj.art-57e5da36589642ed9052a9d3c3c32ce3 |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-12-11T03:09:45Z |
| publishDate | 2019-04-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-57e5da36589642ed9052a9d3c3c32ce32022-12-22T01:22:54ZengElsevier EspañaClinics1980-53222019-04-0174010.6061/clinics/2019/e573S1807-593220190001002217.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson’s disease patientsJia-Wei WangFei CongYan ZhuoLin ChenBo WangYu-Qing ZhangOBJECTIVES: The pedunculopontine nucleus (PPN) is considered a promising new target for neurostimulation in Parkinson’s disease (PD) patients with postural instability and gait disturbance that is refractory to other treatment modalities. However, the PPN is typically difficult to visualize with magnetic resonance imaging (MRI) at clinical field strengths, which greatly limits the PPN as a viable surgical target for deep brain stimulation (DBS). Thus, the aim of this study is to directly visualize the PPN based on 7.0T ultrahigh-field MRI. METHODS: Five PD patients were enrolled and scanned using the MP2RAGE sequence on a 7.0T ultrahigh-field MRI scanner. Then, the MP2RAGE sequences were imported into a commercially available navigation system. The coordinates of the directly localized PPN poles were recorded in the navigation system relative to the anterior commissure-posterior commissure plane. RESULTS: Our results indicated that the PPN presented intermediate signal intensity in the 7.0T ultrahigh-field MR images in comparison with the surrounding structure, such as the hypo-intensity of the periaqueductal gray and the hyperintensity of the neighboring white matter tracts, in PD patients. The mean coordinates for the rostral and caudal poles of PPN were 6.50 mm and 7.20 mm lateral, 1.58 mm and 2.21 mm posterior, and 8.89 mm and 13.83 mm relative to the posterior commissure. CONCLUSION: Our findings provide, for the first time, direct visualization of the PPN using the MP2RAGE sequence on a 7.0T ultrahigh-field MRI, which may improve the accuracy of stereotactic targeting of the PPN and improve the outcomes in patients undergoing DBS.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322019000100221&lng=en&tlng=enParkinson’s DiseasePedunculopontine Nucleus7.0T MRIPostural InstabilityGait Disturbance |
| spellingShingle | Jia-Wei Wang Fei Cong Yan Zhuo Lin Chen Bo Wang Yu-Qing Zhang 7.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson’s disease patients Clinics Parkinson’s Disease Pedunculopontine Nucleus 7.0T MRI Postural Instability Gait Disturbance |
| title | 7.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson’s disease patients |
| title_full | 7.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson’s disease patients |
| title_fullStr | 7.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson’s disease patients |
| title_full_unstemmed | 7.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson’s disease patients |
| title_short | 7.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson’s disease patients |
| title_sort | 7 0t ultrahigh field mri directly visualized the pedunculopontine nucleus in parkinson s disease patients |
| topic | Parkinson’s Disease Pedunculopontine Nucleus 7.0T MRI Postural Instability Gait Disturbance |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322019000100221&lng=en&tlng=en |
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