Insomnia and endothelial function - the HUNT 3 fitness study.
BACKGROUND: Insomnia is associated with increased risk of coronary heart disease (CHD), but the underlying mechanisms are not understood. To our knowledge, no previous studies have examined insomnia in relation to endothelial function, an indicator of preclinical atherosclerosis. Our aim was to asse...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3516514?pdf=render |
| _version_ | 1818136400086695936 |
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| author | Linn B Strand Lars E Laugsand Eli-Anne Skaug Øyvind Ellingsen Erik Madssen Ulrik Wisløff Lars Vatten Imre Janszky |
| author_facet | Linn B Strand Lars E Laugsand Eli-Anne Skaug Øyvind Ellingsen Erik Madssen Ulrik Wisløff Lars Vatten Imre Janszky |
| author_sort | Linn B Strand |
| collection | DOAJ |
| description | BACKGROUND: Insomnia is associated with increased risk of coronary heart disease (CHD), but the underlying mechanisms are not understood. To our knowledge, no previous studies have examined insomnia in relation to endothelial function, an indicator of preclinical atherosclerosis. Our aim was to assess the association of insomnia with endothelial function in a large population based study of healthy individuals. METHODS: A total of 4 739 participants free from known cardiovascular or pulmonary diseases, cancer, and sarcoidosis, and who were not using antihypertensive medication were included in the study. They reported how often they had experienced difficulties falling asleep at night, repeated awakenings during the night, early awakenings without being able to go back to sleep, and daytime sleepiness. Endothelial function was measured by flow mediated dilation (FMD) derived from the brachial artery. RESULTS: We found no consistent association between the insomnia symptoms and endothelial function in multiadjusted models, but individual insomnia symptoms may be related to endothelial function. Among women who reported early awakenings, endothelial function may be lower than in women without this symptom (p = 0.03). CONCLUSIONS: This study provided no evidence that endothelial function, an early indicator of atherosclerosis, is an important linking factor between insomnia and CHD. Further studies are needed to explore the complex interrelation between sleep and cardiovascular pathology. |
| first_indexed | 2024-12-11T09:39:48Z |
| format | Article |
| id | doaj.art-57e64e8cc7c4474e8f99db7e47dfef02 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T09:39:48Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-57e64e8cc7c4474e8f99db7e47dfef022022-12-22T01:12:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01712e5093310.1371/journal.pone.0050933Insomnia and endothelial function - the HUNT 3 fitness study.Linn B StrandLars E LaugsandEli-Anne SkaugØyvind EllingsenErik MadssenUlrik WisløffLars VattenImre JanszkyBACKGROUND: Insomnia is associated with increased risk of coronary heart disease (CHD), but the underlying mechanisms are not understood. To our knowledge, no previous studies have examined insomnia in relation to endothelial function, an indicator of preclinical atherosclerosis. Our aim was to assess the association of insomnia with endothelial function in a large population based study of healthy individuals. METHODS: A total of 4 739 participants free from known cardiovascular or pulmonary diseases, cancer, and sarcoidosis, and who were not using antihypertensive medication were included in the study. They reported how often they had experienced difficulties falling asleep at night, repeated awakenings during the night, early awakenings without being able to go back to sleep, and daytime sleepiness. Endothelial function was measured by flow mediated dilation (FMD) derived from the brachial artery. RESULTS: We found no consistent association between the insomnia symptoms and endothelial function in multiadjusted models, but individual insomnia symptoms may be related to endothelial function. Among women who reported early awakenings, endothelial function may be lower than in women without this symptom (p = 0.03). CONCLUSIONS: This study provided no evidence that endothelial function, an early indicator of atherosclerosis, is an important linking factor between insomnia and CHD. Further studies are needed to explore the complex interrelation between sleep and cardiovascular pathology.http://europepmc.org/articles/PMC3516514?pdf=render |
| spellingShingle | Linn B Strand Lars E Laugsand Eli-Anne Skaug Øyvind Ellingsen Erik Madssen Ulrik Wisløff Lars Vatten Imre Janszky Insomnia and endothelial function - the HUNT 3 fitness study. PLoS ONE |
| title | Insomnia and endothelial function - the HUNT 3 fitness study. |
| title_full | Insomnia and endothelial function - the HUNT 3 fitness study. |
| title_fullStr | Insomnia and endothelial function - the HUNT 3 fitness study. |
| title_full_unstemmed | Insomnia and endothelial function - the HUNT 3 fitness study. |
| title_short | Insomnia and endothelial function - the HUNT 3 fitness study. |
| title_sort | insomnia and endothelial function the hunt 3 fitness study |
| url | http://europepmc.org/articles/PMC3516514?pdf=render |
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