β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion

β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion

Summary: Interleukin-1 receptor antagonist (IL-1Ra) is elevated in the circulation during obesity and type 2 diabetes (T2D) but is decreased in islets from patients with T2D. The protective role of local IL-1Ra was investigated in pancreatic islet β cell (βIL-1Ra)-specific versus myeloid-cell (myelo...

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Bibliographic Details
Main Authors:	Marianne Böni-Schnetzler, Stéphanie P. Häuselmann, Elise Dalmas, Daniel T. Meier, Constanze Thienel, Shuyang Traub, Friederike Schulze, Laura Steiger, Erez Dror, Praxedis Martin, Pedro L. Herrera, Cem Gabay, Marc Y. Donath
Format:	Article
Language:	English
Published:	Elsevier 2018-02-01
Series:	Cell Reports
Subjects:	IL-1 receptor antagonist islet β cells glucose-stimulated insulin secretion β cell proliferation E2F1 transcription factor interleukin-1β
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124718301128

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