In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus

In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus

Snakebite envenoming affects more than 250,000 people annually in sub-Saharan Africa. Envenoming by Dispholidus typus (boomslang) results in venom-induced consumption coagulopathy (VICC), whereby highly abundant prothrombin-activating snake venom metalloproteinases (SVMPs) consume clotting factors a...

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Bibliographic Details
Main Authors: Stefanie K. Menzies, Rachel H. Clare, Chunfang Xie, Adam Westhorpe, Steven R. Hall, Rebecca J. Edge, Jaffer Alsolaiss, Edouard Crittenden, Amy E. Marriott, Robert A. Harrison, Jeroen Kool, Nicholas R. Casewell
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Toxicon: X
Subjects:
Small molecules
Drugs
Boomslang
Snakebite
SVMP
Online Access:http://www.sciencedirect.com/science/article/pii/S2590171022000285

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