The role of bile acids in nutritional support
Abstract Nutritional support continues to receive much attention as a possible intervention to prevent loss of lean tissue mass, promote recovery and re-establish proper immune function in critical care patients. Yet there remains much controversy regarding the clinical efficacy of such intervention...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-09-01
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| Series: | Critical Care |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13054-018-2160-4 |
| _version_ | 1811293879751671808 |
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| author | Gustav van Niekerk Tanja Davis Willem de Villiers Anna-Mart Engelbrecht |
| author_facet | Gustav van Niekerk Tanja Davis Willem de Villiers Anna-Mart Engelbrecht |
| author_sort | Gustav van Niekerk |
| collection | DOAJ |
| description | Abstract Nutritional support continues to receive much attention as a possible intervention to prevent loss of lean tissue mass, promote recovery and re-establish proper immune function in critical care patients. Yet there remains much controversy regarding the clinical efficacy of such interventions. In addition to the direct effect of nutrition in terms of micro- and macronutrient content, nutritional formulations may exert an effect via the physiological response to feeding. Here, we highlight the key role of postprandial reabsorbed bile acids in attenuating both the inflammatory response and autophagy. These observations suggest that not all patients would benefit from aggressive nutritional support. |
| first_indexed | 2024-04-13T05:08:08Z |
| format | Article |
| id | doaj.art-57e910a20b794bdebf0658616ff2e707 |
| institution | Directory Open Access Journal |
| issn | 1364-8535 |
| language | English |
| last_indexed | 2024-04-13T05:08:08Z |
| publishDate | 2018-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Critical Care |
| spelling | doaj.art-57e910a20b794bdebf0658616ff2e7072022-12-22T03:01:07ZengBMCCritical Care1364-85352018-09-012211610.1186/s13054-018-2160-4The role of bile acids in nutritional supportGustav van Niekerk0Tanja Davis1Willem de Villiers2Anna-Mart Engelbrecht3Stellenbosch UniversityStellenbosch UniversityStellenbosch UniversityStellenbosch UniversityAbstract Nutritional support continues to receive much attention as a possible intervention to prevent loss of lean tissue mass, promote recovery and re-establish proper immune function in critical care patients. Yet there remains much controversy regarding the clinical efficacy of such interventions. In addition to the direct effect of nutrition in terms of micro- and macronutrient content, nutritional formulations may exert an effect via the physiological response to feeding. Here, we highlight the key role of postprandial reabsorbed bile acids in attenuating both the inflammatory response and autophagy. These observations suggest that not all patients would benefit from aggressive nutritional support.http://link.springer.com/article/10.1186/s13054-018-2160-4Bile acidsAutophagyFarnesoid-X-receptorInflammationNutritional supportSepsis |
| spellingShingle | Gustav van Niekerk Tanja Davis Willem de Villiers Anna-Mart Engelbrecht The role of bile acids in nutritional support Critical Care Bile acids Autophagy Farnesoid-X-receptor Inflammation Nutritional support Sepsis |
| title | The role of bile acids in nutritional support |
| title_full | The role of bile acids in nutritional support |
| title_fullStr | The role of bile acids in nutritional support |
| title_full_unstemmed | The role of bile acids in nutritional support |
| title_short | The role of bile acids in nutritional support |
| title_sort | role of bile acids in nutritional support |
| topic | Bile acids Autophagy Farnesoid-X-receptor Inflammation Nutritional support Sepsis |
| url | http://link.springer.com/article/10.1186/s13054-018-2160-4 |
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