Genetic exchange and reassignment in Porphyromonas gingivalis
Porphyromonas gingivalis is considered a keystone pathogen in adult periodontitis but has also been associated with systemic diseases. It has a myriad of virulence factors that differ between strains. Genetic exchange and intracellular genome rearrangements may be responsible for the variability in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-01-01
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| Series: | Journal of Oral Microbiology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20002297.2018.1457373 |
| _version_ | 1818265846711058432 |
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| author | Ingar Olsen Tsute Chen Gena D Tribble |
| author_facet | Ingar Olsen Tsute Chen Gena D Tribble |
| author_sort | Ingar Olsen |
| collection | DOAJ |
| description | Porphyromonas gingivalis is considered a keystone pathogen in adult periodontitis but has also been associated with systemic diseases. It has a myriad of virulence factors that differ between strains. Genetic exchange and intracellular genome rearrangements may be responsible for the variability in the virulence of P. gingivalis. The present review discusses how the exchange of alleles can convert this bacterium from commensalistic to pathogenic and potentially shapes the host-microbe environment from homeostasis to dysbiosis. It is likely that genotypes of P. gingivalis with increased pathogenic adaptations may spread in the human population with features acquired from a common pool of alleles. The exact molecular mechanisms that trigger this exchange are so far unknown but they may be elicited by environmental pressure. |
| first_indexed | 2024-12-12T19:57:18Z |
| format | Article |
| id | doaj.art-57e98f298e984d49a232efd114833239 |
| institution | Directory Open Access Journal |
| issn | 2000-2297 |
| language | English |
| last_indexed | 2024-12-12T19:57:18Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj.art-57e98f298e984d49a232efd1148332392022-12-22T00:13:50ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972018-01-0110110.1080/20002297.2018.14573731457373Genetic exchange and reassignment in Porphyromonas gingivalisIngar Olsen0Tsute Chen1Gena D Tribble2University of OsloForsyth InstituteUniversity of Texas Health Science Center at HoustonPorphyromonas gingivalis is considered a keystone pathogen in adult periodontitis but has also been associated with systemic diseases. It has a myriad of virulence factors that differ between strains. Genetic exchange and intracellular genome rearrangements may be responsible for the variability in the virulence of P. gingivalis. The present review discusses how the exchange of alleles can convert this bacterium from commensalistic to pathogenic and potentially shapes the host-microbe environment from homeostasis to dysbiosis. It is likely that genotypes of P. gingivalis with increased pathogenic adaptations may spread in the human population with features acquired from a common pool of alleles. The exact molecular mechanisms that trigger this exchange are so far unknown but they may be elicited by environmental pressure.http://dx.doi.org/10.1080/20002297.2018.1457373Porphyromonas gingivalisadaptabilitysurvivalperiodontitiskeystone pathogen hypothesishomeostasisdysbiosis |
| spellingShingle | Ingar Olsen Tsute Chen Gena D Tribble Genetic exchange and reassignment in Porphyromonas gingivalis Journal of Oral Microbiology Porphyromonas gingivalis adaptability survival periodontitis keystone pathogen hypothesis homeostasis dysbiosis |
| title | Genetic exchange and reassignment in Porphyromonas gingivalis |
| title_full | Genetic exchange and reassignment in Porphyromonas gingivalis |
| title_fullStr | Genetic exchange and reassignment in Porphyromonas gingivalis |
| title_full_unstemmed | Genetic exchange and reassignment in Porphyromonas gingivalis |
| title_short | Genetic exchange and reassignment in Porphyromonas gingivalis |
| title_sort | genetic exchange and reassignment in porphyromonas gingivalis |
| topic | Porphyromonas gingivalis adaptability survival periodontitis keystone pathogen hypothesis homeostasis dysbiosis |
| url | http://dx.doi.org/10.1080/20002297.2018.1457373 |
| work_keys_str_mv | AT ingarolsen geneticexchangeandreassignmentinporphyromonasgingivalis AT tsutechen geneticexchangeandreassignmentinporphyromonasgingivalis AT genadtribble geneticexchangeandreassignmentinporphyromonasgingivalis |