New strategies with anti-IgE in allergic diseases
IgE has long been known as a therapeutic target for allergic disease, but the difficulty has been in selecting agents that don't trigger cross linkage of IgE when bound to its high affinity receptor (FceR1) on mast cells and basophils. By “designing” a monoclonal antibody (mAb) which targets th...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-01-01
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| Series: | World Allergy Organization Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455119302479 |
| _version_ | 1818844743557185536 |
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| author | Stephen T Holgate |
| author_facet | Stephen T Holgate |
| author_sort | Stephen T Holgate |
| collection | DOAJ |
| description | IgE has long been known as a therapeutic target for allergic disease, but the difficulty has been in selecting agents that don't trigger cross linkage of IgE when bound to its high affinity receptor (FceR1) on mast cells and basophils. By “designing” a monoclonal antibody (mAb) which targets that part of IgE that binds to that binds to the a-chain of FceR1, the allergic cascade can be effectively interrupted and diseases such as asthma greatly improved, providing a substantial part of their phenotype engages IgE. Clinical trials and real life studies confirm this. Beyond asthma, a whole range of other diseases dependent upon IgE initiation and triggering are being identified. These diseases are now being explored as being amenable to anti-IgE therapy some of which are comorbidities of asthma and others not. The advent of an even more potent anti-IgE mAb - QGE031 – is creating further opportunities for anti-IgE therapy to improve the lives of so many people with IgE-related diseases. Keywords: Omalizumab, Anti-IgE monoclonal antibody, Asthma, Comorbidity, Allergy |
| first_indexed | 2024-12-19T05:18:37Z |
| format | Article |
| id | doaj.art-57e9c74a784349d1920229f4dd7055bf |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-12-19T05:18:37Z |
| publishDate | 2014-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-57e9c74a784349d1920229f4dd7055bf2022-12-21T20:34:33ZengElsevierWorld Allergy Organization Journal1939-45512014-01-017New strategies with anti-IgE in allergic diseasesStephen T Holgate0Correspondence:; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Mail point 810, Level F, South Block, Southampton SO166YD, UKIgE has long been known as a therapeutic target for allergic disease, but the difficulty has been in selecting agents that don't trigger cross linkage of IgE when bound to its high affinity receptor (FceR1) on mast cells and basophils. By “designing” a monoclonal antibody (mAb) which targets that part of IgE that binds to that binds to the a-chain of FceR1, the allergic cascade can be effectively interrupted and diseases such as asthma greatly improved, providing a substantial part of their phenotype engages IgE. Clinical trials and real life studies confirm this. Beyond asthma, a whole range of other diseases dependent upon IgE initiation and triggering are being identified. These diseases are now being explored as being amenable to anti-IgE therapy some of which are comorbidities of asthma and others not. The advent of an even more potent anti-IgE mAb - QGE031 – is creating further opportunities for anti-IgE therapy to improve the lives of so many people with IgE-related diseases. Keywords: Omalizumab, Anti-IgE monoclonal antibody, Asthma, Comorbidity, Allergyhttp://www.sciencedirect.com/science/article/pii/S1939455119302479 |
| spellingShingle | Stephen T Holgate New strategies with anti-IgE in allergic diseases World Allergy Organization Journal |
| title | New strategies with anti-IgE in allergic diseases |
| title_full | New strategies with anti-IgE in allergic diseases |
| title_fullStr | New strategies with anti-IgE in allergic diseases |
| title_full_unstemmed | New strategies with anti-IgE in allergic diseases |
| title_short | New strategies with anti-IgE in allergic diseases |
| title_sort | new strategies with anti ige in allergic diseases |
| url | http://www.sciencedirect.com/science/article/pii/S1939455119302479 |
| work_keys_str_mv | AT stephentholgate newstrategieswithantiigeinallergicdiseases |