Serum level of vitamin D in preterm infants and its association with premature-related respiratory complications: a case-control study
Background and aim: Prematurity and related problems, especially respiratory distress, are one of the main challenges for neonatal medicine. The aim of this study was to compare vitamin D levels in preterm infants with, and those without respiratory distress. Methods: This case-control study was...
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| Format: | Article |
| Language: | English |
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Electronic Physician
2018-01-01
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| Series: | Electronic Physician |
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853995/ |
| _version_ | 1811329696466468864 |
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| author | Hasan Boskabadi Gholamali Mamoori Seyedeh Fatemeh Khatami Raheleh Faramarzi |
| author_facet | Hasan Boskabadi Gholamali Mamoori Seyedeh Fatemeh Khatami Raheleh Faramarzi |
| author_sort | Hasan Boskabadi |
| collection | DOAJ |
| description | Background and aim: Prematurity and related problems, especially respiratory distress, are one of the main
challenges for neonatal medicine. The aim of this study was to compare vitamin D levels in preterm infants with,
and those without respiratory distress.
Methods: This case-control study was conducted in Ghaem and Emam Reza Hospitals in Mashhad (Iran) from
2015 to 2016. In this study, we examined 160 preterm infants weighing less than 2000 grams and born at less
than 34 weeks’ gestation. Serum vitamin D levels were measured in preterm infants without- and those with
respiratory distress, and their mothers. Neonatal characteristics, including age, sex, birth weight, gestational age,
Apgar score and needs for oxygen, resuscitation, ventilation and surfactant were documented. The data were
analyzed using SPSS version 16.0.
Results: Means serum level of maternal vitamin D in control and case groups were 16.66±14.29 ng/dl and
21.23±15.19 ng/dl, respectively (p=0.029). In addition, mean serum level of neonatal vitamin D in control and
case groups were 11.69±8.66 ng/dl 17.9±12.55 ng/dl, respectively (p=0.001). Vitamin D levels in premature
neonates without respiratory distress and their mothers were significantly different from other preterm neonates
with respiratory distress (p=0.029). There was a direct correlation with neonatal and maternal vitamin D levels
(r=0.713, p=0.001). The duration of hospitalization (p=0.001), gestational age (p=0.073), birth weight (p=0.001),
one- and (p=0.001) five- minute (p=0.001) Apgar scores and head circumference (p=0.002) had significant
relation with vitamin D levels in neonates. Death (12.5%) and pneumothorax (7.5%) were the main complications
among cases with respiratory distress.
Conclusion: According to the results of present research, neonatal vitamin D levels have a significant association
with respiratory distress syndrome and maternal vitamin D levels. |
| first_indexed | 2024-04-13T15:49:48Z |
| format | Article |
| id | doaj.art-57eb79af460a413c9a7d2dc0b3e4be16 |
| institution | Directory Open Access Journal |
| issn | 2008-5842 2008-5842 |
| language | English |
| last_indexed | 2024-04-13T15:49:48Z |
| publishDate | 2018-01-01 |
| publisher | Electronic Physician |
| record_format | Article |
| series | Electronic Physician |
| spelling | doaj.art-57eb79af460a413c9a7d2dc0b3e4be162022-12-22T02:40:53ZengElectronic PhysicianElectronic Physician2008-58422008-58422018-01-011016208621410.19082/6208Serum level of vitamin D in preterm infants and its association with premature-related respiratory complications: a case-control studyHasan BoskabadiGholamali MamooriSeyedeh Fatemeh KhatamiRaheleh FaramarziBackground and aim: Prematurity and related problems, especially respiratory distress, are one of the main challenges for neonatal medicine. The aim of this study was to compare vitamin D levels in preterm infants with, and those without respiratory distress. Methods: This case-control study was conducted in Ghaem and Emam Reza Hospitals in Mashhad (Iran) from 2015 to 2016. In this study, we examined 160 preterm infants weighing less than 2000 grams and born at less than 34 weeks’ gestation. Serum vitamin D levels were measured in preterm infants without- and those with respiratory distress, and their mothers. Neonatal characteristics, including age, sex, birth weight, gestational age, Apgar score and needs for oxygen, resuscitation, ventilation and surfactant were documented. The data were analyzed using SPSS version 16.0. Results: Means serum level of maternal vitamin D in control and case groups were 16.66±14.29 ng/dl and 21.23±15.19 ng/dl, respectively (p=0.029). In addition, mean serum level of neonatal vitamin D in control and case groups were 11.69±8.66 ng/dl 17.9±12.55 ng/dl, respectively (p=0.001). Vitamin D levels in premature neonates without respiratory distress and their mothers were significantly different from other preterm neonates with respiratory distress (p=0.029). There was a direct correlation with neonatal and maternal vitamin D levels (r=0.713, p=0.001). The duration of hospitalization (p=0.001), gestational age (p=0.073), birth weight (p=0.001), one- and (p=0.001) five- minute (p=0.001) Apgar scores and head circumference (p=0.002) had significant relation with vitamin D levels in neonates. Death (12.5%) and pneumothorax (7.5%) were the main complications among cases with respiratory distress. Conclusion: According to the results of present research, neonatal vitamin D levels have a significant association with respiratory distress syndrome and maternal vitamin D levels.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853995/Vitamin DInfantsPrematureRespiratory Distress Syndrome |
| spellingShingle | Hasan Boskabadi Gholamali Mamoori Seyedeh Fatemeh Khatami Raheleh Faramarzi Serum level of vitamin D in preterm infants and its association with premature-related respiratory complications: a case-control study Electronic Physician Vitamin D Infants Premature Respiratory Distress Syndrome |
| title | Serum level of vitamin D in preterm infants and its association with premature-related respiratory complications: a case-control study |
| title_full | Serum level of vitamin D in preterm infants and its association with premature-related respiratory complications: a case-control study |
| title_fullStr | Serum level of vitamin D in preterm infants and its association with premature-related respiratory complications: a case-control study |
| title_full_unstemmed | Serum level of vitamin D in preterm infants and its association with premature-related respiratory complications: a case-control study |
| title_short | Serum level of vitamin D in preterm infants and its association with premature-related respiratory complications: a case-control study |
| title_sort | serum level of vitamin d in preterm infants and its association with premature related respiratory complications a case control study |
| topic | Vitamin D Infants Premature Respiratory Distress Syndrome |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853995/ |
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